Perifollikuläre Fibromatose. Eine kutane Paraneoplasie?

Simon, M. Celeste; Hornstein, O. P.; Haneke, E.

doi:10.1007/978-3-642-82021-2_44

Cited by 4 publications

(3 citation statements)

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“…Multiple follicular neoplasia may be asso ciated with internal neoplasms; examples of such associations arc multiple trichoepithe lioma-like tumors and breast carcinoma [14], perifollicular fibromas with colonic polyposis [3] or adenocarcinoma [15], and the multiple trichilemmoma constituting the Cowden's syndrome [ 16], There is no as sociation between the Birt-Hogg-Dube syn drome and internal neoplasia. The original report of Bin et al [4] is about a family with both familial medullary carcinoma of the thyroid and cutaneous lesions, but was re ported as the intermingling of two different inherited traits.…”

Section: Commentmentioning

confidence: 99%

Multiple Fibrofolliculomas and Trichodiscomas

Moreno¹,

Puig

Moragas

1985

Dermatology

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A late-onset, sporadic case of multiple fibrofolliculomas and trichodiscomas is reported. This case and other reports in the literature suggest to the authors that benign neoplasms derived from the mesodermal component of the pilar apparatus may present in various combinations and may also be associated with other hamartomatous skin proliferations. The wide spectrum of published combinations may be due to similarities in clinical presentation and biopsy-sampling uncertainties

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Section: Commentmentioning

confidence: 99%

Multiple Fibrofolliculomas and Trichodiscomas

Moreno¹,

Puig

Moragas

1985

Dermatology

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“…Careful observation of slides often reveals a pronounced collagen sheath around blood vessels in the immediate vicinity of the perifollicular fibromas (Figure 2). 45,46 Electron microscopy shows abundant tropocollagen and procollagen fibrils forming transversely banded structures called fibrous long spacing collagen. 45 Fibrofolliculomas are round to oval perifollicular fibromas in the upper and middle dermis.…”

Section: Histopathologymentioning

confidence: 99%

“…45,46 Electron microscopy shows abundant tropocollagen and procollagen fibrils forming transversely banded structures called fibrous long spacing collagen. 45 Fibrofolliculomas are round to oval perifollicular fibromas in the upper and middle dermis. The stroma is relatively loose and mucin rich but may also be dense and almost hyaline (Figure 3).…”

Section: Histopathologymentioning

confidence: 99%

What is in a name—Perifollicular fibroma or fibrofolliculoma?

Haneke,

Happle

2023

J Cutan Pathol

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So far, confusion exists regarding the question of whether hereditary perifollicular fibromas and fibrofolliculomas can be distinguished from each other. Here, histopathological arguments are presented to clarify this terminological problem. In 1977, Birt et al. described a large kindred affected with hereditary multiple “fibrofolliculomas,” which they thought were “a hitherto unrecognized pilar hamartoma,” but they never claimed the fibrofolliculomas were part of a syndrome. A careful microscopic comparison shows, however, that the tumors are clinically and histopathologically identical to perifollicular fibromas, as first described by Burnier and Rejšek in 1925. Their familial occurrence was discovered in 1971 by Civatte and Le Tréguilly. Before 1977, the term “perifollicular fibroma” was used for these skin tumors. By contrast, Hornstein and Knickenberg described in 1975 perifollicular fibromas as a cutaneous marker of a syndrome characterized by a predisposition to colon cancer and pneumothorax. Later, two French groups erroneously proposed the term “Birt–Hogg–Dubé syndrome” to describe the co‐occurrence of fibrofolliculomas, trichodiscomas, and acrochordons, which was contrary to what Birt et al. had in mind. Hence, today, we should discriminate between the hereditary nonsyndromic perifollicular fibromas, as documented by Civatte and Le Tréguilly and later by Birt et al., and the syndromic perifollicular fibromas, as delineated by Hornstein and Knickenberg.

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