Perifoveal Capillary Network in Patients with Acute Central Retinal Vein Occlusion

Remky, Andreas; Wolf, Sebastián; Knabben, Hildegard; Arend, Oliver; Reim, Martin

doi:10.1016/s0161-6420(97)30365-0

Cited by 34 publications

(30 citation statements)

References 18 publications

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“…17 Meanwhile, fluorescein angiography has become a widespread diagnostic method for studying retinal microcirculation in vivo. 6,18,19 Quantification of morphologic and haemodynamic parameters has become possible because of improved digital image acquisition and analysis. 20 In patients with mild to moderate hypertensive fundus changes, a significant reduction of PIA and CBV has already been demonstrated, 7 whereby the amount of reduction was found to be independent from the applied antihypertensive drugs.…”

Section: Discussionmentioning

confidence: 99%

Do angiographic data support a detailed classification of hypertensive fundus changes?

Pache

Kube²,

Wolf

et al. 2002

J Hum Hypertens

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Section: Discussionmentioning

confidence: 99%

Do angiographic data support a detailed classification of hypertensive fundus changes?

Pache

Kube²,

Wolf

et al. 2002

J Hum Hypertens

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“…Considering previous publications that documented it, 8,10,21 we classified the macula as either perfused with a capillary plexus around the entire circumference of the FAZ or non-perfused, in which the FAZ was in contact with the NPA.…”

Section: Fluorescein Angiographymentioning

confidence: 99%

Relationship between perifoveal capillaries and pathomorphology in macular oedema associated with branch retinal vein occlusion

Murakami

Tsujikawa

Miyamoto

et al. 2012

Eye

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“…5 Previous studies have further shown an enlargement of the foveal avascular zone (FAZ) in patients with retinal vein occlusion. 6,7 Until recently, the only way to evaluate the FAZ was by fluorescein angiography (FA), an invasive and time consuming examination associated with adverse effects including nausea, vomiting, rash, and even anaphylaxis and sudden death. 8,9 Furthermore, during the early stages of CRVO, FA has several limitations in providing information about retinal capillary obliteration due to hemorrhage and edema.…”

mentioning

confidence: 99%

Optical Coherence Tomography Angiography in Central Retinal Vein Occlusion: Correlation Between the Foveal Avascular Zone and Visual Acuity

Salles

Kvanta

Amrén

et al. 2016

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. To investigate the relationship between best-corrected visual acuity (BCVA) and the foveal avascular zone (FAZ) in patients with central retinal vein occlusion (CRVO) evaluated with optical coherence angiography (OCT-A).METHODS. The study was a prospective consecutive case series including 24 patients with CRVO. All patients received either aflibercept or ranibizumab intravitreal injections prior to analysis. Best-corrected visual acuity and FAZ were evaluated in eyes without macular edema. The FAZ areas were evaluated with OCT-A in both the superficial and deep capillary plexus layers by using 3 3 3-mm images of the macula. Disruption of the ellipsoid zone (EZ) was also analyzed.RESULTS. The mean superficial FAZ area measured 0.76 mm 2 (95% confidence interval [CI] 0.50-1.13). The mean deep FAZ area measured 1.12 mm 2 (95% CI 0.77-1.47). In a multivariable analysis a negative correlation was found between the BCVA and the superficial FAZ area (r ¼ À0.54, P ¼ 0.03). The correlation between the BCVA and deep FAZ area did not meet statistical significance (r ¼ À0.43, P ¼ 0.09). In a multivariable analysis, disruption of the ellipsoid zone was significantly correlated to a larger superficial FAZ area (r ¼ 0.68, P ¼ <0.001) and poor visual acuity (r ¼ 0.75, P < 0.001).CONCLUSIONS. Optical coherence tomography-A is a novel technique that allows segmented evaluation of the FAZ in patients with CRVO providing additional prognostic information. The FAZ areas were enlarged both in the superficial and the deep capillary networks. A significant correlation was found between BCVA and the FAZ area in CRVO patients without macular edema (ClinicalTrials.gov, number NCT02274259).

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Perifoveal Capillary Network in Patients with Acute Central Retinal Vein Occlusion

Cited by 34 publications

References 18 publications

Do angiographic data support a detailed classification of hypertensive fundus changes?

Do angiographic data support a detailed classification of hypertensive fundus changes?

Relationship between perifoveal capillaries and pathomorphology in macular oedema associated with branch retinal vein occlusion

Optical Coherence Tomography Angiography in Central Retinal Vein Occlusion: Correlation Between the Foveal Avascular Zone and Visual Acuity

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