Perigraft vascularization and incorporation of implanted Dacron prostheses are affected by rifampicin coating

Moussavian, M. R.; Laschke, Matthias W.; Schlachtenberger, Georg; Heesen, Maximilian von; Wagner, M.; Glanemann, Matthias; Menger, Michael D.

doi:10.1016/j.jvs.2015.07.104

Cited by 12 publications

(2 citation statements)

References 43 publications

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“…The antibacterial efficacy of rifampicin or rifampicin/tobramycin loaded prostheses was demonstrated by infected dog model [9,10]. However, the spectrum of activity of this combination of antibiotics is limited to gram positive bacteria, and thus, clinical results in terms of efficacy and integration have shown controversial effects [11,12]. Compared to antibiotic loaded grafts, the efficacy of silver, however, is much lower as expected [13,14,15,16].…”

Section: Introductionmentioning

confidence: 99%

Ciprofloxacin loaded vascular prostheses functionalized with poly-methylbeta- cyclodextrin: The importance of in vitro release conditions

Garcia-Fernandez

Maton

Benzine

et al. 2019

Journal of Drug Delivery Science and Technology

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HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.

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Section: Introductionmentioning

confidence: 99%

Ciprofloxacin loaded vascular prostheses functionalized with poly-methylbeta- cyclodextrin: The importance of in vitro release conditions

Garcia-Fernandez

Maton

Benzine

et al. 2019

Journal of Drug Delivery Science and Technology

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“…Long-term RIF treatment can cause hepatocyte dysfunction and cholestatic liver injury (Grobbelaar et al, 2019;Yang et al, 2020c). The mechanism of RIF-induced drug-induced liver injury (DILI) remains undefined and may occur by cholestasis, oxidative stress, inflammatory response, mitochondrial damage, and apoptosis (Moussavian et al, 2016;Yang et al, 2020c;Luo et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Screening of Biomarkers and Toxicity Mechanisms of Rifampicin-Induced Liver Injury Based on Targeted Bile Acid Metabolomics

Deng

Luo

et al. 2022

Front. Pharmacol.

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Rifampicin (RIF) is a critical first-line drug for tuberculosis. However, long-term or high-dose treatment with RIF can induce severe liver injury; the underlying mechanism of this effect has not yet been clarified. This study was performed to screen reliable and sensitive biomarkers in serum bile acids (BAs) using targeted BA metabolomics and evaluate the toxicity mechanisms underlying RIF-induced liver injury through the farnesoid x receptor (Fxr)-multidrug resistance-associated proteins (Mrps) signaling pathway. Thirty-two Institute of Cancer Research mice were randomly divided into four groups, and normal saline, isoniazid 75 mg/kg + RIF 177 mg/kg (RIF-L), RIF-L, or RIF 442.5 mg/kg (RIF-H) was orally administered by gavage for 21 days. After treatment, changes in serum biochemical parameters, hepatic pathological conditions, BA levels, Fxr expression, and BA transporter levels were measured. RIF caused notable liver injury and increased serum cholic acid (CA) levels. Decline in the serum secondary BAs (deoxycholic acid, lithocholic acid, taurodeoxycholic acid, and tauroursodeoxycholic acid) levels led to liver injury in mice. Serum BAs were subjected to metabolomic assessment using partial least squares discriminant and receiver operating characteristic curve analyses. CA, DCA, LCA, TDCA, and TUDCA are potential biomarkers for early detection of RIF-induced liver injury. Furthermore, RIF-H reduced hepatic BA levels and elevated serum BA levels by suppressing the expression of Fxr and Mrp2 messenger ribonucleic acid (mRNA) while inducing that of Mrp3 and Mrp4 mRNAs. These findings provide evidence for screening additional biomarkers based on targeted BA metabolomics and provide further insights into the pathogenesis of RIF-induced liver injury.

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Infection Control in Prosthetic Surgery

Ianni,

Pizza,

Siani

et al. 2024

Updates in Surgery

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Perigraft vascularization and incorporation of implanted Dacron prostheses are affected by rifampicin coating

Cited by 12 publications

References 43 publications

Ciprofloxacin loaded vascular prostheses functionalized with poly-methylbeta- cyclodextrin: The importance of in vitro release conditions

Ciprofloxacin loaded vascular prostheses functionalized with poly-methylbeta- cyclodextrin: The importance of in vitro release conditions

Screening of Biomarkers and Toxicity Mechanisms of Rifampicin-Induced Liver Injury Based on Targeted Bile Acid Metabolomics

Infection Control in Prosthetic Surgery

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