Perihepatic lymph node enlargement observed at a general health examination: A cross‐sectional study

Abstract

The incidence of PLNE in the general population may vary with the prevalence of chronic liver disease, especially HCV infection. When PLNE is observed, liver disorders should be first surveyed including HCV infection even with normal serum alanine aminotransferase levels. PLNE with para-aortic lymph node enlargement may be suggestive of a malignant lesion. The incidence of PLNE of unknown etiology may be approximately 1% in the general population, which may be just followed up without further change.

Potential associations between perihepatic lymph node enlargement and liver fibrosis, hepatocellular injury or hepatocarcinogenesis in chronic hepatitis B virus infection

“…Thus, PLNE may be observed in as much as 10% of patients with chronic HBV infections. Then, we compared the frequency of PLNE in subjects with different backgrounds; in our previous studies, PLNE was detected in 20.0% (169/846) of patients with CHC and in 1.6% (69/4234) of subjects who underwent a general health examination . As shown in Figure , the frequency of PLNE in patients with chronic HBV infection was significantly higher than that in subjects undertaking a general health examination ( P < 0.0001) but lower than that in CHC patients ( P < 0.0001).…”

“…We examined the association between PLNE and clinical findings such as liver fibrosis, hepatocellular injury or the presence of HCC in patients with chronic HBV infection (the primary end‐point of this study). We previously reported the prevalence of PLNE in the patients with CHC or the patients underwent general health examinations (general population) . Using the results of our previous studies, we then compared the prevalence of PLNE in the patients with chronic HBV infection to patients with CHC or general population (the secondary end‐point).…”

“…We previously reported the prevalence of PLNE in the patients with CHC 17 or the patients underwent general health examinations (general population). 19 Using the results of our previous studies, we then compared the prevalence of PLNE in the patients with chronic HBV infection to patients with CHC or general population (the secondary end-point).…”

Prognostic Factors and Clinical Characteristics for Hepatocellular Carcinoma Patients with Benign Enlarged Perihepatic Lymph Nodes: a Single-Center Experience from China

“…21 -24 Lymph nodes of lymphatic circulation system in liver are well known to exist in the porta hepatis area, and inflammatory processes in organs frequently give rise to hyperplasia of regional lymph nodes. 25 As described in detail previously, 6 Dietrich et al had investigated the volume of enlarged lymph nodes within the hepatoduodenal ligament among HCV patients, and concluded that PLNE is a predictive factor for the presence of severe inflammatory activity. In their study, the mean perihepatic lymph node volume in healthy controls was lower than in HCV-infected patients (2.2±1.8 ml versus 16.0±13.2 ml; p<10 −6 ).…”