“…Post-mortem MPF and histology studies of MS ( Schmierer et al, 2007 ; Bagnato et al, 2018 ) confirmed good agreement between demyelination and a reduced MPF. The majority of MS studies utilized multipoint techniques with either off-resonance saturation ( Sled and Pike, 2001 ; Yarnykh, 2002 ; Tozer et al, 2003 , 2005 ; Davies et al, 2003 , 2004 ; Levesque et al, 2005 ; Narayanan et al, 2006 ; Schmierer et al, 2007 ; Cercignani et al, 2009 ; Giacomini et al, 2009 ; Levesque et al, 2010a ; Spano et al, 2010 ) or selective inversion-recovery preparation ( Bagnato et al, 2018 , 2020 ; McKeithan et al, 2019 ; Clarke et al, 2021 ) to obtain MPF maps. The single-point method ( Yarnykh, 2012 ) extended the area of MPF applications to GM ( Yarnykh et al, 2015 , 2018a ) and demonstrated strong associations of GM MPF with MS disability scales and disease phenotype ( Yarnykh et al, 2015 ).…”