Perillyl Alcohol Is an Angiogenesis Inhibitor

Pharmaceutical and therapeutic Potentials of essential oils and their individual volatile constituents: a review

“…Thus, antiangiogenic therapy is one of the most promising approaches to control cancer. Perillyl alcohol (POH) which is the hydroxylated analogue of d-limonene, has the ability to interfere with angiogenesis (Loutrari et al, 2004). POH either alone or with PA (perillic acid, the major metabolite of POH in the body), has a potential use as an anticancer drug that stimulates different types of tumors to apoptosis, inhibits their proliferation, or overcomes their resistance to chemo-/radiotherapy (Yuri et al, 2004;Samaila et al, 2004;Elegbede et al, 2003;Clark et al, 2003;Ahn et al, 2003;Bardon et al, 2002;Burke et al, 2002;Bardon et al, 1998).…”

Biosynthesis and Therapeutic Properties ofLavandulaEssential Oil Constituents

“…Such investigations have shown that there are compounds found in trace amounts in lavender oils which have potentially significant anticancer activity [49]. One such component, the monoterpenoid perillyl alcohol, has been investigated as a potential component of anticancer treatments [50], and has been shown to inhibit angiogenic cell growth and division in vitro [51]. Subsequent studies into the chemoprevention potential of perillyl alcohol were undertaken in National Cancer Institute-sponsored phase I, II, and III trials for prostate, breast, and colon cancers.…”

Cell Cycle Arrest by the Isoprenoids Perillyl Alcohol, Geraniol, and Farnesol Is Mediated by p21Cip1and p27Kip1in Human Pancreatic Adenocarcinoma Cells

“…In addition to early findings that isoprenoids may inhibit posttranslational protein prenylation (Crowell et al, 1991;Ren et al, 1997), reported effects include induction of G 0 /G 1 cell cycle arrest (Yu et al, 1995;Miquel et al, 1998;Clark et al, 2002;Elegbede et al, 2003), increased apoptosis (Haug et al, 1994;Mills et al, 1995;Reddy et al, 1997;Stayrook et al, 1997;Ariazi et al, 1999;Rioja et al, 2000;Burke et al, 2002;Clark et al, 2002;Elegbede et al, 2003;Xu et al, 2004), transient G 2 /M phase arrest (Shi and Gould, 2002;Rajesh and Howard, 2003), inhibition of cholesterol biosynthesis (Ren and Gould, 1994;Peffley and Gayen, 2003), inhibition of angiogenesis (Loutrari et al, 2004), and increased sensitization to radiation and anticancer drugs (Samaila et al, 2004).…”