Perimenopause: The Complex Endocrinology of the Menopausal Transition

Prior, Jerilynn C.

doi:10.1210/er.19.4.397

Cited by 82 publications

(26 citation statements)

References 34 publications

(106 reference statements)

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“…Several neurocognitive functions are known be modulated over the course of the menstrual cycle, during pregnancy, or across the life span 50 . The complex endocrinology of menopausal transition is believed to be caused by decreasing estrogen levels 3,51 . These aspects of the audiometric configuration should be investigated further in larger series.…”

Section: Hormones and The Auditory Systemmentioning

confidence: 99%

Effect of exercise on the auditory discrimination task in perimenopausal women: a preliminary study

Hwang

Chen

et al. 2016

Climacteric

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Background The climacteric phase of menopausal transition (perimenopause) is marked by reproductive hormone fluctuations and reduced cognitive capacity. Exercise enhances neurocognitive performance. However, auditory perceptual sensitivity has not been examined. Purpose This study aimed to determine the effect of aerobic exercise on the response speed (reaction time) and error rate during auditory processing among perimenopausal women. Methods Three pitches (500, 1000, and 2000 Hz) were used during a simple auditory discrimination task, which was performed before and after exercise. We included 14 perimenopausal women and 17 right-handed young women (aged 46-54 years and 18-22 years, respectively). To achieve similar exercise intensity in both groups, we proposed two types of physical activities for each group. Mixed models statistics were used to analyze the reaction time and error rate before and after training in the two groups. Results Perimenopausal women exhibited a significantly longer reaction time than young women during the baseline auditory discrimination task (p< 0.05) but not during the second test. The error rate decreased significantly after exercise among perimenopausal women (p < 0.05) but not among young women. Thus, exercise had a stronger beneficial influence on auditory plasticity or sensitivity for perimenopausal women than for young women. Conclusion The ability of aerobic exercise to modulate auditory neurocognitive performance differs between the two groups. Aerobic exercise improves auditory discrimination performance specifically for perimenopausal women. These results provide preliminary evidence concerning the acoustic features of middle-aged women, underscoring the importance of exercise for preventing decline in auditory cognitive function in perimenopausal women.

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Section: Hormones and The Auditory Systemmentioning

confidence: 99%

Effect of exercise on the auditory discrimination task in perimenopausal women: a preliminary study

Hwang

Chen

et al. 2016

Climacteric

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“…2 An increase in FSH stimulates ovarian folliculogenesis, which occurs at an accelerated rate up until the menopause when all follicles are depleted. 8,9,53 Increased folliculogenesis results in increased oestrogen production, which may contribute to irregular bleeding.…”

Section: Natural Family Planning Methodsmentioning

confidence: 99%

“…50 Conflicting evidence exists on bone loss in the perimenopause. 52,53 Nevertheless the majority of studies have not supported rapid bone loss in the perimenopause before the last menstrual period. 50,52 Conflicting evidence exists on the effect of COC on age-related loss in bone mineral density (BMD).…”

Section: Cervical Cancermentioning

confidence: 99%

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FFPRHC Guidance (January 2005) Contraception for women aged over 40 years

2005

j fam plann reprod health care

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This Guidance provides information for clinicians and for women aged over 40 years considering the use of contraception. A key to the grades of recommendations, based on levels of evidence, is given at the end of this document. Details of the methods used by the Clinical Effectiveness Unit (CEU) in developing this Guidance and evidence tables summarising the research basis of the recommendations are available on the Faculty website (www.ffprhc.org.uk). Abbreviations (in alphabetical order) used include: BMD, bone mineral density; CEU, Clinical Effectiveness Unit; CI, confidence interval; COC, combined oral contraception; DMPA, depot medroxyprogesterone acetate; EE, ethinylestradiol; HPV, human papilloma virus; IUD, copper-bearing intrauterine contraceptive device; LNG-IUS, levonorgestrel-releasing intrauterine system; MI, myocardial infarction; OR, odds ratio; POC, progestogen-only contraception; POP, progestogen-only pill; RR, relative risk; STI, sexually transmitted infection; VTE, venous thromboembolism; WHO, World Health Organization; WHOMEC, WHO Medical Eligibility Criteria for Contraceptive Use; WHOSPR, WHO Selected Practice Recommendations for Contraceptive Use.

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“…Once defined, researched, diagnosed and treated as a deficiency disease, menopause becomes the conceptual and practical property of medical specialists whose authority over its treatment was, until recently, rarely questioned (Bell 1990;MacPherson, 1985;Martin, 1992). The relatively new phenomenon of peri-menopause has gained popularity over the last decade and has been defined as a "period of time that is the transition between the reproductive years and menopause" (Prior, 1998). This recent focus on what can only be described as a "pre-transitional" phase of women's reproductive life is quickly becoming the arena of further medicalization.…”

Section: Reductionist Model Of Menopausementioning

confidence: 99%

A feminist analysis of the menopause discourse

Loppie

Keddy

2002

Contemporary Nurse

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Menopause has been viewed as a medical condition which needs to be treated. The discourse surrounding the process reflects a positivist paradigm without acknowledgement of the lived experiences of women who have been given conflicitng information. In this paper we write about the dilemmas faced by peri menopausal, menopausal and post menopausal women as they grapple with the issues that focus on 'symptoms', rather than a natural phenomenon. We point out that the 'science' of menopause is class, race and gender biased as we present a feminist analysis of the concerns facing mid life women.

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Perimenopause: The Complex Endocrinology of the Menopausal Transition

Cited by 82 publications

References 34 publications

Effect of exercise on the auditory discrimination task in perimenopausal women: a preliminary study

Effect of exercise on the auditory discrimination task in perimenopausal women: a preliminary study

FFPRHC Guidance (January 2005) Contraception for women aged over 40 years

A feminist analysis of the menopause discourse

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