Perimesencephalic hemorrhage

Gijn, J. van; Dongen, K. J. van; Vermeulen, M.; Hijdra, A.

doi:10.1212/wnl.35.4.493

Cited by 401 publications

(256 citation statements)

References 0 publications

Supporting

Mentioning

235

Contrasting

Unclassified

Order By: Relevance

“…1,2 Since the systematic description by van Gijin et al, 3 perimesencephalic (pm)SAH and non-perimesencephalic (non-pm)SAH are commonly distinguished 1,2,4 In patients with pmSAH, the blood is located strictly around the midbrain and/or brainstem (Fig. 1A), while in patients with non-pmSAH the hemorrhage extends into adjacent cisterns (Fig.…”

Section: Introductionmentioning

confidence: 99%

Systemic interleukin-6 concentrations in patients with perimesencephalic non-aneurysmal subarachnoid hemorrhage

Muroi

Bellut

Coluccia

et al. 2011

Journal of Clinical Neuroscience

View full text Add to dashboard Cite

Patients with spontaneous non-aneurysmal subarachnoid hemorrhage (non-aSAH) are considered to have a benign illness in contrast to patients with aSAH. The occurrence of the systemic inflammatory response syndrome has been linked to worse outcomes in patients with aSAH. We analyzed systemic interleukin (IL)-6, a proinflammatory cytokine, to determine whether its concentration differs between patients with non-aSAH and those with aSAH, reflecting the more benign illness. Daily systemic IL-6 levels were measured in the acute phase in 11 patients with non-aneurysmal perimesencephalic SAH (pmSAH), with bleeding strictly located around the midbrain, and in nine patients with non-aneurysmal non-perimesencephalic (non-pmSAH), with hemorrhage extending into adjacent cisterns (group 1). IL-6 levels were compared with those from patients suffering from aSAH with cerebral vasospasm (CVS) (group 2) and without CVS (group 3). The mean IL-6 level (±standard error of the mean) was significantly lower in group 1 compared to group 2 (9.9±1.9 vs. 29.1±6.7pg/mL, p=0.018). The difference in mean IL-6 level between group 1 and 3 fell short of significance (9.9±1.9 vs. 14.9±1.1pg/mL, p=0.073). Patients in group 1 had a significantly better outcome (Glasgow Outcome Scale score 4-5) compared to group 2 (p<0.001) and a trend towards better outcome compared to group 3 (p=0.102). A subgroup analysis revealed a higher mean IL-6 concentration in patients with non-pmSAH compared to patients with pm-SAH (p=0.001). We concluded that systemic IL-6 concentration reflects the severity of the inflammatory stress response and course of the illness. The more benign illness and good prognosis of patients with pmSAH or non-pmSAH in contrast to patients with aSAH is reflected by the lower concentrations of IL-6.

show abstract

Section: Introductionmentioning

confidence: 99%

Systemic interleukin-6 concentrations in patients with perimesencephalic non-aneurysmal subarachnoid hemorrhage

Muroi

Bellut

Coluccia

et al. 2011

Journal of Clinical Neuroscience

View full text Add to dashboard Cite

show abstract

“…1 These patients often exhibit a pattern of hemorrhage on CT scans that is known as NAPH. This pattern was first described by van Gijn et al in 1985 2 as an SAH in which blood was limited primarily to the perimesencephalic cisterns with no evidence of aneurysm on angiography.…”

mentioning

confidence: 69%

“…Studies have shown that Ͼ90% of patients who present with the NAPH pattern have limited morbidity, and mortality is extremely rare. [2][3][4] These observed outcomes are in contrast to those of untreated aneurysmal SAH, in which morbidity and mortality rates are Ͼ50%.…”

mentioning

confidence: 93%

Inter- and Intraobserver Agreement in CT Characterization of Nonaneurysmal Perimesencephalic Subarachnoid Hemorrhage

Brinjikji¹,

Kallmes²,

White³

et al. 2010

AJNR Am J Neuroradiol

View full text Add to dashboard Cite

show abstract

“…6) Generally, the clinical manifestation of PNSAH is sudden onset of headache, similar to that of aneurysmal SAH. 8) The natural history of PNSAH is benign, and PNSAH causing focal neurological deficit such as unilateral cranial nerve palsy is quite rare. Recently, the prevalence of anosmia was reported as one in 16 of patients with PNSAH.…”

Section: Introductionmentioning

confidence: 99%

Perimesencephalic Nonaneurysmal Subarachnoid Hemorrhage With Unilateral Third Cranial Nerve Palsy

Sadamasa

Sano

Takeda

et al. 2012

Neurol. Med. Chir.(Tokyo)

View full text Add to dashboard Cite

Perimesencephalic nonaneurysmal subarachnoid hemorrhage (PNSAH) is a benign form of subarachnoid hemorrhage and is usually not associated with any focal deficit. We describe two rare cases of PNSAH with unilateral third cranial nerve palsy. Both patients were treated conservatively. The outcomes of our two cases were excellent. The third cranial nerve palsy resolved gradually in both patients, suggesting that the prognosis for third cranial nerve palsy concomitant with PNSAH is favorable. Unilateral third cranial nerve palsy may occur as the first clinical manifestation of PNSAH.

show abstract

Perimesencephalic hemorrhage

Cited by 401 publications

References 0 publications

Systemic interleukin-6 concentrations in patients with perimesencephalic non-aneurysmal subarachnoid hemorrhage

Systemic interleukin-6 concentrations in patients with perimesencephalic non-aneurysmal subarachnoid hemorrhage

Inter- and Intraobserver Agreement in CT Characterization of Nonaneurysmal Perimesencephalic Subarachnoid Hemorrhage

Perimesencephalic Nonaneurysmal Subarachnoid Hemorrhage With Unilateral Third Cranial Nerve Palsy

Contact Info

Product

Resources

About