Perimyocardial Injury Specific for SARS-CoV-2-Induced Myocarditis in Comparison With Non-COVID-19 Myocarditis

“…Studies including patients who recovered from COVID-19 reported increased [4,27,28,33,35,36], slightly increased [29,32,38,39,41] or similar [31,34] T1 native mapping values compared to controls. In particular, Kotecha et al [28], Puntmann et al [35], and Thornton et al [37] found significantly higher T1 native mapping values in large groups of recovered subjects (148, 100 and 90, respectively) compared to different control groups, including patients without myocardial injury, healthy volunteers or controls, and risk factor-matched controls [26,28,35,37]. In addition, patients who recovered from COVID-19 and had MIS-myocarditis had higher T1 native values than those with non-MIS myocarditis [30].…”

Section: Parametric Mappingmentioning

confidence: 97%

“…We identified 648 records, from which 60 were retrieved for further analysis. Following the eligibility assessment, nineteen studies were finally included in this review [4,[24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41]; their characteristics are shown in Table 1 (Ref. [4,[24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41]).…”

Section: Cmr Findings In Recovered Covid-19 Patientsmentioning

confidence: 99%

“…Cohort description T2 (ms) 1 Visible edema (N (%)) 1 Pericardial effusion (N (%)) 1 Pericardial enhancement (N (%)) 1 Field strength = 1.5 T Kotecha et al [28] LGE data from the selected reports are summarized in Table 4 (Ref [4,[24][25][26][27][28]30,31,33,[35][36][37][38][39][40][41]). Kotecha et al [28] found significant positive LGE in 49% of the patients who recovered from COVID-19, Thornton et al [37] reported it in 56%, and Puntmann et al [35] found 32% (myocardial) and 22% (pericardial).…”

Section: Authormentioning

confidence: 99%

“…Kotecha et al [28] found significant positive LGE in 49% of the patients who recovered from COVID-19, Thornton et al [37] reported it in 56%, and Puntmann et al [35] found 32% (myocardial) and 22% (pericardial). An author reported LGE with non-specific distribution and appearance [24], while others found subepicardial, subendocardial, and intramyocardial [25,28,41], myocarditis-like [4,26], and nonischemic [33,38] patterns. Generally, LGE patterns can help differentiate between ischemic and non-ischemic myocardial injury.…”

Section: Authormentioning

confidence: 99%

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CMR Findings in COVID-19 Recovered Patients: A Review on Parametric Mapping, Feature-Tracking, and LGE

Mojica-Pisciotti¹,

Panovský²,

Holeček³

et al. 2022

Rev. Cardiovasc. Med.

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On March 11, 2020, the World Health Organization raised the coronavirus disease 2019 status to a pandemic level. The disease caused a global outbreak with devastating consequences, and a fair percentage of patients who have recovered from it continue experiencing persistent sequelae. Hence, identifying the medium and long-term effects of the COVID-19 disease is crucial for its future management. In particular, cardiac complications, from affected function to myocardial injuries, have been reported in these patients. Considering that cardiovascular magnetic resonance (CMR) imaging is the gold standard in diagnosing myocardial involvement and has more advantages than other medical imaging modalities, assessing the outcomes of patients who recovered from COVID-19 with CMR could prove beneficial. This review compiles common findings in CMR in patients from the general population who recovered from COVID-19. The CMR-based techniques comprised parametric mapping for analyzing myocardial composition, feature tracking for studying regional heart deformation, and late gadolinium enhancement for detecting compromised areas in the cardiac muscle. A total of 19 studies were included. The evidence suggests that it is more likely to find signs of myocardial injury in patients who recovered from COVID-19 than in healthy controls, including changes in T1 and T2 mapping relaxation times, affected strain, or the presence of late gadolinium enhancement (LGE) lesions. However, more than two years after the outbreak, there is still a lack of consensus about how these parameters may indicate cardiac involvement in patients who recovered from the disease, as limited and contradictory data is available.

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Viral Myocarditis and Dilated Cardiomyopathy as a Consequence—Changing Insights from Advanced Imaging

Kang

Friedrich

Abramov

et al. 2023

Heart Failure Clinics

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Perimyocardial Injury Specific for SARS-CoV-2-Induced Myocarditis in Comparison With Non-COVID-19 Myocarditis

Cited by 7 publications

References 4 publications

Advanced cardiac imaging in the spectrum of COVID-19 related cardiovascular involvement

Advanced cardiac imaging in the spectrum of COVID-19 related cardiovascular involvement

CMR Findings in COVID-19 Recovered Patients: A Review on Parametric Mapping, Feature-Tracking, and LGE

Viral Myocarditis and Dilated Cardiomyopathy as a Consequence—Changing Insights from Advanced Imaging

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