Perinatal and childhood factors and risk of breast cancer subtypes in adulthood

Lope, Virginia; García‐Esquinas, Esther; Pérez‐Gómez, Beatriz; Altzibar, Jone M.; Gràcia-Lavedán, Esther; Ederra, María; Torre, Antonio José Molina de la; Llorca, Javier; Tardón, Adonina; Bayo, Juan; Salas-Trejo, Dolores; Marcos‐Gragera, Rafael; Pumarega, José; Dierssen-Sotos, Trinidad; Lera, Juan Pablo Barrio; Medina, M.A. Concepción de Miguel; Tusquets, Ignasi; Amiano, Pilar; Boldo, Elena; Kogevinas, Manolis; Aragonés, Núria; Castaño‐Vinyals, Gemma; Pollán, Marina

doi:10.1016/j.canep.2015.11.004

Cited by 14 publications

(17 citation statements)

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“…Possible explanations for the inconsistent results for postmenopausal breast cancer may include: ( i ) different studies used different cutpoints for higher birth weight and performed different comparisons; ( ii ) a higher birthweight in different study populations may be a surrogate for a different constellation of prenatal and postnatal factors rather than an indicator of an elevated estrogenic prenatal environment. For example, a higher birthweight may be viewed as an indicator of better prepregnancy health of the women's mothers, or better overall economic and physical environments of women's childhood life, which may lead to lower risk of breast cancer . However, WHI did not collect information on the socioeconomic status of the women's parents.…”

Section: Discussionmentioning

confidence: 99%

Birth weight, weight over the adult life course and risk of breast cancer

Luo

Chen

Manson

et al. 2019

Intl Journal of Cancer

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Breast cancer has been suggested to potentially have prenatal origins. We examined associations between birth weight, body mass index (BMI) at four-time points over 25 years of adulthood, and risk of postmenopausal breast cancer, with emphasis on whether the association between birth weight and risk of breast cancer was mediated by weight and height changes over the adult life course. Postmenopausal women (n = 70,397) aged 50-79 years without breast cancer at enrollment (1993)(1994)(1995)(1996)(1997)(1998) were followed up to 25 years. Weight and height were measured at baseline. Birth weight, and weights at ages 18, 35 and 50 were self-reported. Breast cancer cases were centrally adjudicated. Compared to women with birth weight of 6-8 pounds, women with birth weight of <6 pounds had lower risk of breast cancer (HR = 0.88 95% CI: 0.79-0.99). 44% and 21% of the relationship between birth weight and breast cancer risk was mediated by adult height and weight at baseline, respectively. Birth weight of 8 pounds or more was not associated with risk of postmenopausal breast cancer. Weight gain in adulthood was associated with increased risk of breast cancer regardless of time periods. In conclusion, lower birthweight was associated with lower risk of postmenopausal breast cancer, and this reduction in risk was significantly mediated by childhood or adolescent growth, especially by adult height. Our data suggest that reaching and maintaining a healthy weight during adulthood is key in the prevention of breast cancer.Additional Supporting Information may be found in the online version of this article.

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Section: Discussionmentioning

confidence: 99%

Birth weight, weight over the adult life course and risk of breast cancer

Luo

Chen

Manson

et al. 2019

Intl Journal of Cancer

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“…MCC-Spain (http://www.mccspain.org/) is a population-based multicase-control study conducted between 2008 and 2013 in 12 Spanish provinces to identify environmental, personal and genetic factors related to five common cancers, including BC [10]. The selection of cases and controls has been previously described in detail [10,11]. Briefly, a single set of population controls were frequency matched by age and sex with the overall distribution of all cancer cases.…”

Section: Methodsmentioning

confidence: 99%

Adherence to the Western, Prudent and Mediterranean dietary patterns and breast cancer risk: MCC-Spain study

et al. 2017

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“…To date, health effects which have been suggested as linked to TCS exposure in the population include breast cancer in adult women [64] a feature that could be related to early pubertal development [65]. TCS has also been related to cardiovascular diseases [66, 67].…”

Section: Discussionmentioning

confidence: 99%

Comparison of methods for calculating the health costs of endocrine disrupters: a case study on triclosan

Přichystalová¹,

Fini²,

Trasande

et al. 2017

Environ Health

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BackgroundSocioeconomic analysis is currently used in the Europe Union as part of the regulatory process in Regulation Registration, Evaluation and Authorisation of Chemicals (REACH), with the aim of assessing and managing risks from dangerous chemicals. The political impact of the socio-economic analysis is potentially high in the authorisation and restriction procedures, however, current socio-economic analysis dossiers submitted under REACH are very heterogeneous in terms of methodology used and quality. Furthermore, the economic literature is not very helpful for regulatory purposes, as most published calculations of health costs associated with chemical exposures use epidemiological studies as input data, but such studies are rarely available for most substances. The quasi-totality of the data used in the REACH dossiers comes from toxicological studies.MethodsThis paper assesses the use of the integrated probabilistic risk assessment, based on toxicological data, for the calculation of health costs associated with endocrine disrupting effects of triclosan. The results are compared with those obtained using the population attributable fraction, based on epidemiological data.ResultsThe results based on the integrated probabilistic risk assessment indicated that 4894 men could have reproductive deficits based on the decreased vas deferens weights observed in rats, 0 cases of changed T3 levels, and 0 cases of girls with early pubertal development.The results obtained with the Population Attributable Fraction method showed 7,199,228 cases of obesity per year, 281,923 girls per year with early pubertal development and 88,957 to 303,759 cases per year with increased total T3 hormone levels.The economic costs associated with increased BMI due to TCS exposure could be calculated. Direct health costs were estimated at €5.8 billion per year.ConclusionsThe two methods give very different results for the same effects. The choice of a toxicological-based or an epidemiological-based method in the socio-economic analysis will therefore significantly impact the estimated health costs and consequently the political risk management decision. Additional work should be done for understanding the reasons of these significant differences.Electronic supplementary materialThe online version of this article (doi:10.1186/s12940-017-0265-x) contains supplementary material, which is available to authorized users.

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Perinatal and childhood factors and risk of breast cancer subtypes in adulthood

Abstract: These data reflect the importance of hormones and growth factors in the early stages of life, when the mammary gland is in development and therefore more vulnerable to proliferative stimuli.

Cited by 14 publications

References 80 publications

Birth weight, weight over the adult life course and risk of breast cancer

Birth weight, weight over the adult life course and risk of breast cancer

Adherence to the Western, Prudent and Mediterranean dietary patterns and breast cancer risk: MCC-Spain study

Comparison of methods for calculating the health costs of endocrine disrupters: a case study on triclosan

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