Perinatal and Postnatal Exposure to Bisphenol A Increases Adipose Tissue Mass and Serum Cholesterol Level in Mice

Miyawaki, Joji; Sakayama, Kenshi; Kobayashi, Hideo; Yamamoto, Haruyasu; Masuno, Hiroshi

doi:10.5551/jat.e486

Cited by 248 publications

(181 citation statements)

References 36 publications

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“…These results are consistent with those of other investigators who showed that perinatal BPA exposure increased body weight relative to controls (Rubin et al 2001;Miyawaki et al 2007). In addition, several investigators confirmed that BPA has a role in weight gain and the development of obesity (Newbold et al 2009;Rubin and Soto 2009;Shankar et al 2012).…”

Section: Discussionsupporting

confidence: 83%

The effect of bisphenol A on some oxidative stress parameters and acetylcholinesterase activity in the heart of male albino rats

Khadrawy²,

2013

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Bisphenol A (BPA) is an endocrine disrupting chemical used on a wide range in industry. Several studies reported that BPA may cause cardiovascular disorders in humans and animals. The present study aims to investigate the effect of BPA on the heart of adult male rats. The rats received a daily oral administration of BPA (25 mg/kg for 6 weeks and 10 mg/kg for 6 and 10 weeks). It was found that BPA at the two studied doses induced a significant increase in malondialdehyde, and a significant decrease in catalase after 6 weeks. Moreover, a significant decrease in reduced glutathione and acetylcholinesterase (AchE) activity was observed after treatment with the two doses of BPA throughout the studied time intervals. The two doses (25 and 10 mg/kg) resulted in a significant decrease in nitric oxide (NO) levels after 6 and 10 weeks, respectively. A significant increase in body weight gain occurred in all animals after BPA treatment. These results suggest that BPA has cardiotoxic effects which are mediated by the oxidative stress resulting from the overproduction of free radicals, the deficiency of NO and the inhibition of AchE leading to cholinergic activation. The obesity promoting effect of BPA may also participate in the observed cardiovascular disturbances.

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Section: Discussionsupporting

confidence: 83%

The effect of bisphenol A on some oxidative stress parameters and acetylcholinesterase activity in the heart of male albino rats

Khadrawy²,

2013

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“…This contrasts with adult studies that have linked BPA levels with cardiovascular disease and diabetes, 2 as well as mouse studies showing elevated cholesterol levels among mice with perinatal and postnatal exposure to BPA. 47 Based on these results, we consider the possibility that BPA may not have adverse effects on cardiovascular and diabetes risk. However, our cross-sectional study design may have also limited our findings, given that the adverse effects of BPA could compound over time, with health effects that manifest later in adulthood.…”

Section: Discussionmentioning

confidence: 99%

Bisphenol A and Chronic Disease Risk Factors in US Children

Eng¹,

Lee²,

Gebremariam³

et al. 2013

Pediatrics

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WHAT'S KNOWN ON THIS SUBJECT: Bisphenol A (BPA) is a known endocrine disruptor found in many products with which children come into contact. Although BPA in adults is associated with obesity, diabetes, and cardiovascular disease, little is known about its effects in children. WHAT THIS STUDY ADDS:This study found that higher BPA levels are associated with obesity and abnormal waist circumferenceto-height ratio in children. abstract OBJECTIVE: To evaluate the relationship between urinary bisphenol A (BPA) levels and measures of adiposity and chronic disease risk factors for a nationally representative US pediatric sample. METHODS:We used the NHANES 2003-2010 to evaluate cross-sectional associations between urinary BPA and multiple measures of adiposity, cholesterol, insulin, and glucose for children aged 6 to 18 years, adjusting for relevant covariates (eg, demographics, urine creatinine, tobacco exposure, and soda consumption). RESULTS:We found a higher odds of obesity (BMI $95th percentile) with increasing quartiles of BPA for quartiles 2 vs 1 (odds ratio [OR] 1.74, 95% confidence interval [CI] 1.17-2.60, P = .008), 3 vs 1 (OR 1.64, 95% CI 1.09-2.47, P = .02), and 4 vs 1 (OR 2.01, 95% CI 1.36-2.98, P = .001). We also found a higher odds of having an abnormal waist circumference-to-height ratio (quartiles 2 vs 1 [OR 1.37, 95% CI 0.98-1.93, P = .07], 3 vs 1 [OR 1.41, 95% CI 1.07-1.87, P = .02], and 4 vs 1 [OR 1.55, 95% CI 1.12-2.15, P = .01]). We did not find significant associations of BPA with any other chronic disease risk factors.CONCLUSIONS: Higher levels of urinary BPA were associated with a higher odds of obesity (BMI .95%) and abnormal waist circumference-to-height ratio. Longitudinal analyses are needed to elucidate temporal relationships between BPA exposure and the development of obesity and chronic disease risk factors in children. Pediatrics 2013;132:e637-e645 AUTHORS:

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“…For example, BPA has been shown to promote adipocyte differentiation and fat accumulation, 9 as well as bind to estrogen receptors on adipocytes and inhibit the release of the hormone adiponectin. 37 While most animal studies focused on in utero exposure, Miyawaki et al 10 showed that BPA exposure during both perinatal and postnatal periods led to weight gain in mice. Additionally, long-term exposure to BPA in adult mice was shown to increase a dipose tissue mass and induce insulin resistance, hyperglycemia, and hypercholesterolemia, 38 suggesting the role of BPA in the development of obesity and cardiometabolic dysfunction.…”

Section: Discussionmentioning

confidence: 99%

Urinary bisphenol A and obesity in adults: results from the Canadian Health Measures Survey

Minh

Chang

Mendez

et al. 2017

Health Promot Chronic Dis Prev Can

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Introduction Exposure to bisphenol A (BPA) has been shown to affect lipid metabolism and promote weight gain in animal studies. Recent epidemiological studies also support a link between BPA and obesity in human populations, although many were limited to a single adiposity measure or have not considered potential confounding by dietary factors. The purpose of this study is to examine associations between urinary BPA and adiposity measures in a nationally representative sample of Canadian adults. Methods We performed analyses using biomonitoring and directly measured anthropometric data from 4733 adults aged 18 to 79 years in the Canadian Health Measures Survey (2007–2011). We used multinomial and binary logistic regression models to estimate associations of urinary BPA with body mass index (BMI) categories (overweight vs. under/normal weight; obesity vs. under/normal weight) and elevated waist circumference (males: ≥ 102 cm; females: ≥ 88 cm), respectively, while controlling for potential confounders. Linear regression analyses were also performed to assess associations between urinary BPA and continuous BMI and waist circumference measures. Results Urinary BPA was positively associated with BMI-defined obesity, with an odds ratio of 1.54 (95% confidence interval [CI]: 1.002–2.37) in the highest (vs. lowest) BPA quartile (test for trend, p = .041). Urinary BPA was not associated with elevated waist circumference defined using standard cut-offs. Additionally, each natural-log unit increase in urinary BPA concentration was associated with a 0.33 kg/m2 (95% CI: 0.10– 0.57) increase in BMI and a 1.00 cm (95% CI: 0.34–1.65) increase in waist circumference. Conclusion Our study contributes to the growing body of evidence that BPA is positively associated with obesity. Prospective studies with repeated measures are needed to address temporality and improve exposure classification.

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Perinatal and Postnatal Exposure to Bisphenol A Increases Adipose Tissue Mass and Serum Cholesterol Level in Mice

Cited by 248 publications

References 36 publications

The effect of bisphenol A on some oxidative stress parameters and acetylcholinesterase activity in the heart of male albino rats

The effect of bisphenol A on some oxidative stress parameters and acetylcholinesterase activity in the heart of male albino rats

Bisphenol A and Chronic Disease Risk Factors in US Children

Urinary bisphenol A and obesity in adults: results from the Canadian Health Measures Survey

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