Perinatal antecedents of moderate and severe neonatal hypoxic ischaemic encephalopathy: An Australian birth cohort study

Stoke, Rosie; Schreiber, Veronika; Hocking, Kaycee; Jardine, Luke; Kumar, Sailesh

doi:10.1111/ajo.13665

Cited by 3 publications

(1 citation statement)

References 34 publications

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“…Neonatal hypoxic–ischemic encephalopathy (HIE) is characterized by severe intrauterine hypoxia and abnormalities in cerebral blood flow, which can lead to extensive apoptosis of neonatal brain cells and ultimately to death ( Torn et al, 2023 ). HIE is reported to put 15 per 10,000 live births at risk in high-income countries ( Stoke et al, 2023 ).…”

Section: Introductionmentioning

confidence: 99%

The association between plasma IgG N-glycosylation and neonatal hypoxic–ischemic encephalopathy: a case-control study

Wang,

Lu,

Wang

et al. 2024

Front. Cell. Neurosci.

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IntroductionHypoxic-ischemic encephalopathy (HIE) is one of severe neonatal brain injuries, resulting from inflammation and the immune response after perinatal hypoxia and ischemia. IgG N-glycosylation plays a crucial role in various inflammatory diseases through mediating the balance between anti-inflammatory and pro-inflammatory responses. This study aimed to explore the effect of IgG N-glycosylation on the development of HIE.MethodsThis case-control study included 53 HIE patients and 57 control neonates. An ultrahigh-performance liquid chromatography (UPLC) method was used to determine the features of the plasma IgG N-glycans, by which 24 initial glycan peaks (GPs) were quantified. Multivariate logistic regression was used to examine the association between initial glycans and HIE, by which the significant parameters were used to develop a diagnostic model. Though receiver operating characteristic (ROC) curves, area under the curve (AUC) and 95% confidence interval (CI) were calculated to assess the performance of the diagnostic model.ResultsThere were significant differences in 11 initial glycans between the patient and control groups. The levels of fucosylated and galactosylated glycans were significantly lower in HIE patients than in control individuals, while sialylated glycans were higher in HIE patients (p < 0.05). A prediction model was developed using three initial IgG N-glycans and fetal distress, low birth weight, and globulin. The ROC analysis showed that this model was able to discriminate between HIE patients and healthy individuals [AUC = 0.798, 95% CI: (0.716–0.880)].DiscussionIgG N-glycosylation may play a role in the pathogenesis of HIE. Plasma IgG N-glycans are potential noninvasive biomarkers for screening individuals at high risk of HIE.

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Section: Introductionmentioning

confidence: 99%

The association between plasma IgG N-glycosylation and neonatal hypoxic–ischemic encephalopathy: a case-control study

Wang,

Lu,

Wang

et al. 2024

Front. Cell. Neurosci.

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Predictive utility of the fetal cerebroplacental ratio for hypoxic ischaemic encephalopathy, severe neonatal morbidity and perinatal mortality in late‐preterm and term infants

Bendall

Schreiber

Crawford

et al. 2023

Aust NZ J Obst Gynaeco

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AimsThe aim of this study was to evaluate the association of a low cerebroplacental ratio (CPR) with hypoxic ischaemic encephalopathy (HIE), severe neonatal morbidity (SNM) and perinatal mortality (PNM).MethodsThis was a retrospective cohort study of late‐preterm and term births at Mater Mothers’ Hospital, Brisbane, between 2016 and 2020. Study outcomes were HIE, PNM and SNM (a composite of severe acidosis, Apgar score less than four at 5 min, severe respiratory distress or need for significant cardiopulmonary resuscitation at birth). Univariate and multivariable logistic regressions were used to determine if a low CPR was associated with HIE, SNM or PNM.ResultsA total of 51 870 births met the inclusion criteria. Of these, 216 (0.42%) were complicated by HIE, 10 224 (19.7%) had SNM and 251 (0.48%) had PNM. Rates of low CPR (<10th and <5th centile) were significantly higher in the SNM cohort (20.1 and 13.2%, respectively) and PNM cohort (21.1 and 15.1%, respectively) compared to the overall cohort. A low CPR was associated with significantly increased adjusted odds for SNM but not for HIE or PNM. The area under the receiver operating characteristic curve for CPR <10th centile was greatest for SNM (0.768) and lowest for HIE (0.595). Predictive margins of a low CPR for HIE, SNM and PNM were significant only for SNM at late‐preterm gestations.ConclusionsA low CPR is associated with increased odds of SNM in infants born >34 weeks’ gestation but not for HIE or PNM.

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Recognising risk of neonatal encephalopathy with advancing gestation in nulliparous women is crucial for case review

Battin,

Sadler,

Hill

2023

Arch Dis Child Fetal Neonatal Ed

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Perinatal antecedents of moderate and severe neonatal hypoxic ischaemic encephalopathy: An Australian birth cohort study

Cited by 3 publications

References 34 publications

The association between plasma IgG N-glycosylation and neonatal hypoxic–ischemic encephalopathy: a case-control study

The association between plasma IgG N-glycosylation and neonatal hypoxic–ischemic encephalopathy: a case-control study

Predictive utility of the fetal cerebroplacental ratio for hypoxic ischaemic encephalopathy, severe neonatal morbidity and perinatal mortality in late‐preterm and term infants

Recognising risk of neonatal encephalopathy with advancing gestation in nulliparous women is crucial for case review

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