Perinatal Changes of Plasma Free Amino Acids in Normal and Hypoxic Rabbits

Stave, Uwe; Armstrong, Marvin D.

doi:10.1159/000240530

Cited by 10 publications

(9 citation statements)

References 9 publications

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“…A similar role has been suggested for glutamine (9). It is not clear how the newborn liver is able to concentrate alanine (+ 192 %) after 24 h of hypoxia while the plasma level remains unchanged (1).…”

Section: Discussionmentioning

confidence: 55%

“…New Zealand albino rabbits o f the same inbred strain dealt with in the previous experi ments were used, and the conditions for maintaining control and hypoxic animals were the same as reported earlier (1). The newborns were kept in an atmosphere with 7 % and the adult rabbits were supplied with 9 % oxygen with 5 % carbon dioxide in nitrogen.…”

Section: Animals and Methodsmentioning

confidence: 99%

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Free Amino Acids in Newborn and Adult Rabbit Liver after Prolonged Hypoxia

Stave¹,

Armstrong²

1976

Neonatology

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Newborn and adult rabbits were kept in incubators with a low oxygen atmosphere for 12 and 24 h. In these animals the free amino acids of the liver were quantitated by column chromatography. The most apparent changes were a decrease in the concentrations of most of the liver amino acids after 12 h hypoxia in newborns and a general increase in concentrations in hypoxic adults. Lysine and alanine were markedly increased after 24 h hypoxia in both newborns and adults but were increased after 12 h only in the adult livers.

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Section: Discussionmentioning

confidence: 55%

Section: Animals and Methodsmentioning

confidence: 99%

Free Amino Acids in Newborn and Adult Rabbit Liver after Prolonged Hypoxia

Stave¹,

Armstrong²

1976

Neonatology

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“…Usually newborn rabbits will be nursed within hours after birth, often within the first hour. Thus, a fasting newborn rabbit of more than 3 h of age is not physiologic [27], This age group, however, has been needed as control for hypoxia experiments in which it was necessary to transfer the newborns into an incubator. The lower tissue levels of some amino acids (Ala, Asp and Ser) found in 12-to 30-hour-old fasting rabbits perhaps reflect the relative state of nutritional deficiency.…”

Section: Resultsmentioning

confidence: 99%

“…The levels of taurine are much higher than the adult levels during the perinatal period in liver (table I), muscle (table III) and plasma [27]. Newborn human infants excrete large amounts of taurine [4], Thus, it was somewhat surprising to find the kidney taurine level before and immediately after birth to be about the same as the adult level (table II).…”

Section: Resultsmentioning

confidence: 99%

“…These higher tissue concentrations of free amino acids are accompanied by elevated plasma levels [9] as we have recently reported for the immediate perinatal period of rabbits [27], Except for the study of fetal human liver [21], perinatal liver and brain in rhesus monkeys [15] and of some values for liver and kidney amino acids in infants and children [29] no other investigation of perinatal changes in tissue free amino acids has come to our attention.…”

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confidence: 99%

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Tissue Free Amino Acid Concentrations in Perinatal Rabbits

Stave¹,

Armstrong²

1973

Neonatology

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Free amino acids were measured in extracts from liver, kidney, and skeletal muscle (m. psoas major) of fetal, newborn, and adult rabbits. The total amount of free amino acids is at a higher level in fetal tissues than in adults; this difference is rather small in the liver, slightly larger in renal and very marked in muscle tissue. Perinatal changes of individual amino acid concentrations are different in each tissue studied. Many of such changes can be interpreted as a reflection of the metabolic sitation in each organ, e.g., the great need for essential amino acids during phases of very active protein synthesis. There were essentially no good correlations between developmental changes occurring in tissues and those in plasma.

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Alterations in plasma amino acid levels in children with asthma: A preliminary investigation

Inselman

Khan

Evans

1986

Pediatric Pulmonology

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Concentrations of plasma amino acids and cortisol were measured in 27 children with status asthmaticus, moderate, or mild asthma and in 7 controls without lung disease. Individuals with conditions potentially altering amino acid levels were excluded. Measurements were made at 8 A.M. and 4 P.M. on the same day. Of the 24 amino acids analyzed, threonine, serine, citrulline, tyrosine, proline, alanine, cystine, isoleucine, ornithine, lysine, and arginine were decreased at 8 A.M. or 4 P.M. and plasma cortisol was elevated at 4 P.M. in patients with status asthmaticus when compared with the other groups (p less than 0.05). Normal diurnal variations of amino acids and cortisol were preserved in all groups. Sequential daily determinations in eight patients with status asthmaticus showed progressive increases in total and many individual amino acids as symptoms subsided. These studies demonstrate a decrease of certain gluconeogenic amino acids in the plasma in status asthmaticus. This diminution could reflect the need for maintenance of normal glucose concentrations in status asthmaticus. The decrease in gluconeogenic amino acid levels may play a role in the severity of asthma.

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Perinatal Changes of Plasma Free Amino Acids in Normal and Hypoxic Rabbits

Cited by 10 publications

References 9 publications

Free Amino Acids in Newborn and Adult Rabbit Liver after Prolonged Hypoxia

Free Amino Acids in Newborn and Adult Rabbit Liver after Prolonged Hypoxia

Tissue Free Amino Acid Concentrations in Perinatal Rabbits

Alterations in plasma amino acid levels in children with asthma: A preliminary investigation

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