Perinatal complications and long-term neurodevelopmental outcome of infants with intrauterine growth restriction

Beckerath, A. von; Kollmann, Markus; Rotky-Fast, C.; Karpf, E; Lang, Uwe; Klaritsch, Philipp

doi:10.1016/j.ajog.2012.11.014

Cited by 161 publications

(108 citation statements)

References 29 publications

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“…26 Our findings suggest that the risk for schizophrenia related to fetal size may lie with IUGR, a pathological mechanism associated in the general population with elevated rates of infant mortality and neurodevelopmental impairment in infants and children. 27,31,32 Precise timing of IUGR is often unknown. In the single subject in our sample clinically diagnosed with IUGR through serial ultrasounds, findings were normal at 15 weeks gestational age but showed progressively decelerating growth at 36 and 38.5 weeks.…”

Section: Sga Birth Weight Iugr and Aberrant Neurodevelopmental Trajmentioning

confidence: 99%

Fetal growth and gestational factors as predictors of schizophrenia in 22q11.2 deletion syndrome

Van

Butcher

Costain

et al. 2016

Genetics in Medicine

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Section: Sga Birth Weight Iugr and Aberrant Neurodevelopmental Trajmentioning

confidence: 99%

Fetal growth and gestational factors as predictors of schizophrenia in 22q11.2 deletion syndrome

Van

Butcher

Costain

et al. 2016

Genetics in Medicine

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“…SGA can be due to several factors including maternal factors (such as chronic and pregnancy-induced hypertension and severe chronic disease), fetal factors (congenital anomalies), placental factors (insufficiency) and a constitutional small size. SGA is associated with increased neonatal mortality and morbidity, including chronic lung disease, respiratory distress syndrome, intraventricular hemorrhage and necrotizing enterocolitis (NEC) [1,2,3,4,5,6,7]. NEC is one of the most severe gastrointestinal emergencies in neonates and occurs in approximately 1-8% of all neonatal intensive care unit admissions.…”

Section: Introductionmentioning

confidence: 99%

Necrotizing Enterocolitis in Small-for-Gestational-Age Neonates: A Matched Case-Control Study

Ree¹,

Smits-Wintjens²,

Rijntjes-Jacobs³

et al. 2013

Neonatology

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Background: Small for gestational age (SGA) neonates are at increased risk of mortality and morbidity, including necrotizing enterocolitis (NEC), but detailed information on the incidence and risk factors of NEC in SGA neonates is lacking. Objective: This study aims to estimate the incidence of NEC in a large cohort of SGA neonates, compared to appropriate for gestational age (AGA) neonates. Methods: We included all SGA neonates without congenital malformations admitted to our neonatal nursery between 2004 and 2013. Neonates in the SGA group were matched for gestational age with a control group of AGA neonates admitted during the same study period. We recorded the occurrence of NEC and studied the association with SGA and other potential risk factors. Results: A total of 475 SGA neonates were matched for gestational age at birth to 475 control AGA neonates. The incidence of NEC in the SGA group was 3.2% (15/475) versus 1.3% (6/475) in the AGA group (OR 2.55, 95% CI 0.98-6.63, p = 0.047). The incidence of NEC in the subgroups with mild, moderate and severe SGA was 2.3% (5/215), 4.7% (5/1.07) and 3.2% (5/153), respectively (p = 0.531). Conclusions: The risk of development of NEC is more than twofold increased in SGA neonates compared to AGA neonates. We found no association between the severity of SGA and NEC.

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“…Fetal growth is associated with neurocognitive outcome, since premature newborns who are small for their GA are at a higher risk of cognitive and behavioral or scholar difficulties, particularly in the context of fetal growth restriction [4,5,6]…”

Section: Introductionmentioning

confidence: 99%

Fetal and Postnatal Head Circumference Growth: Synergetic Factors for Neurodevelopmental Outcome at 2 Years of Age for Preterm Infants

Sicard¹,

Nusinovici

Hanf

et al. 2017

Neonatology

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Preterm infants present higher risk of non-optimal neurodevelopmental outcome. Fetal and postnatal growth, in particular head circumference (HC), is associated with neurodevelopmental outcome. Objectives: We aimed to calculate the relationship between HC at birth, HC delta Z-score (between birth and hospital discharge), and non-optimal neurodevelopmental outcome at 2 years of corrected age in preterm infants. Methods: Surviving infants born ≤34 weeks of gestation were included in the analysis. The relationship between the risk of being non-optimal at 2 years and both HC at birth and HC growth was assessed. The 2 Z-scores were considered first independently and then simultaneously to investigate their effect on the risk of non-optimality using a generalized additive model. Results: A total of 4,046 infants with both HC measures at birth and hospital discharge were included. Infants with small HC at birth (Z-score <-2 SD), or presenting suboptimal HC growth (dZ-score <-2 SD), are at higher risk of non-optimal neurodevelopmental outcome at 2 years (respectively OR 1.7 [95% CI 1.4-2] and OR 1.4 [95% CI 1.2-1.8]). Interestingly, patients cumulating small HC Z-score at birth (-2 SD) and presenting catch-down growth (HC dZ-score [-2 SD]) have a significantly increased risk for neurocognitive impairment (OR >2) while adjusting for gestational age, twin status, sex, and socioeconomic information. Conclusions: HC at birth and HC dZ-score between birth and hospital discharge are synergistically associated to neurodevelopmental outcome at 2 years of corrected age, in a population-based prospective cohort of preterm infants born ≤34 weeks of gestation.

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Perinatal complications and long-term neurodevelopmental outcome of infants with intrauterine growth restriction

Cited by 161 publications

References 29 publications

Fetal growth and gestational factors as predictors of schizophrenia in 22q11.2 deletion syndrome

Fetal growth and gestational factors as predictors of schizophrenia in 22q11.2 deletion syndrome

Necrotizing Enterocolitis in Small-for-Gestational-Age Neonates: A Matched Case-Control Study

Fetal and Postnatal Head Circumference Growth: Synergetic Factors for Neurodevelopmental Outcome at 2 Years of Age for Preterm Infants

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