Perinatal exposure to music protects spatial memory against callosal lesions

Abstract

Several studies have indicated that the exposure of rodents to music modulates brain development and neuroplasticity, by mechanisms that involve facilitated hippocampal neurogenesis, neurotrophin synthesis and glutamatergic signaling. This study focused on the potential protection that the perinatal exposure to music, between postnatal days 2 and 32, could offer against functional deficits induced by neonatal callosotomy in rats. The spontaneous alternation and marble-burying behaviors were longitudinally measured in callosotomized and control rats that had been exposed to music or not. The results indicated that the neonatal callosotomy-induced spontaneous alternation deficits that became apparent only after postnatal day 45, about the time when the rat corpus callosum reaches its maximal levels of myelination. The perinatal exposure to music efficiently protected the spontaneous alternation performance against the deficits induced by callosotomy. The present findings may offer important insights into music-induced neuroplasticity, relevant to brain development and neurorehabilitation.

Music Affects Rodents: A Systematic Review of Experimental Research

“…Twenty-one studies investigated the effects of music on behavioral outcomes (see Table 3) (Rauscher et al, 1998; Morton et al, 2001; Chikahisa et al, 2006, 2007; Kim et al, 2006; Angelucci et al, 2007a; Feduccia and Duvauchelle, 2008; Meng et al, 2009; Xu et al, 2009; Amagdei et al, 2010; Li et al, 2010; da Cruz et al, 2011; de Camargo et al, 2013; Escribano et al, 2014; Cruz et al, 2015; Jiang et al, 2016; Lee et al, 2016; Xing et al, 2016a,b,c; Yazdani et al, 2016)—specifically learning abilities, anxiety-related behavior and stereotypic behavior as investigated by behavioral tests explained in Supplementary Material III.…”

“…Music interventions enhanced learning abilities of rodents, specifically those involved with spatial learning (Rauscher et al, 1998; Chikahisa et al, 2006; Kim et al, 2006; Xu et al, 2009; Amagdei et al, 2010; Jiang et al, 2016; Lee et al, 2016; Xing et al, 2016a,b,c; Yazdani et al, 2016). Moreover, music statistically significantly decreased anxiety-related behavior in seven out of nine studies (Angelucci et al, 2007a; Chikahisa et al, 2007; Meng et al, 2009; Li et al, 2010; de Camargo et al, 2013; Escribano et al, 2014; Cruz et al, 2015); the remaining two studies found no differences between music and comparator groups (Amagdei et al, 2010; da Cruz et al, 2011). The anxiety-decreasing effect of music diminished after ovariectomy and was restored by progesterone (Chikahisa et al, 2007; Escribano et al, 2014).…”

Mozart Etki̇si̇

“…Müziğin sıçan ve farelerdeki etkisini inceleyen davranış çalışmalarında müzik dinleyen gruplarda uzamsal öğrenmenin arttığı (20,22,26,35,38,43,(51)(52)(53)(54)(55)(56)(57), anksiyetenin ise azaldığı (39,41,(58)(59)(60)(61)(62) gözlenmiştir. Farelerde K.448 dinletilerek uzamsal öğrenme ve bellekte uzun süreli artış görülmüştür (55).…”

Patrones de movimiento en campo abierto de la rata con conducta autista sometida a estimulación musical

“…11 Las investigaciones en animales muestran que la exposición a algunas composiciones de Mozart (sonata para dos pianos K.448) tiene efectos óptimos en la conducta. Dentro de los hallazgos se encontró que animales con esta estimulación musical, eran más rápidos y cometían menos errores en las pruebas realizadas en un laberinto múltiple en T. 12 Utilizando también otras sonatas de Mozart (K.280 F, K.282 E, K.283 G), se ha observado el efecto neuroprotector a largo plazo contra déficits de memoria espacial, 13 sugiriendo que la música estimula el procesamiento de la información espacial, así como mecanismos de excitación emocional. 13 A pesar de la serie de investigaciones que a la fecha se han desarrollado en relación con la música y su efecto en la conducta motora, se carece de estudios que analicen el efecto de la estimulación musical en ratas con autismo inducido, lo que constituyó el obejtivo del presente trabajo.…”