Perinatal Hypoxia Induces Anterior Chamber Changes in the Eyes of Offspring Fish

Chan, Ching Yuen; Lam, Wai Ping; Wai, Maria Sen Mun; Wang, Mingwei; Foster, Elizabeth Lucy; Yew, David T.

doi:10.1262/jrd.19018

Cited by 4 publications

(2 citation statements)

References 35 publications

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“…More typically, however, chronic hypoxia has been shown to cause an assortment of phenotypic changes in a diverse range of organ systems and fi sh species, including the hearts of zebrafi sh and cichlids (Haplochromis piceatus) (Marques et al 2008); the reproductive tracts of common carp (Wang et al 2008) and Atlantic croaker (Micropogonias undulatus) (Thomas et al 2007); peripheral blood leukocytes of tilapia (Choi et al 2007); and the eyes of platyfi sh (Xiphophorus maculatus) exposed to hypoxic conditions perinatally (Chan et al 2007). In the gills, hypoxia has been associated with an adaptive increase in lamellar surface area in fi shes such as certain African cichlids and Crucian carp (Carassius carassius) (Chapman et al 2000;Sollid et al 2003;van der Meer et al 2005).…”

Section: Hypoxiamentioning

confidence: 99%

“…For example, fi ndings in perinatal platyfi sh subjected to hypoxic conditions included central corneal thinning, hyperplasia of corneal endothelial cells, lens fi ber derangement, and apoptotic cells in the retina (Chan et al 2007). Perhaps more obvious were the corneal ulcerations induced by acute confi nement stress in hybrid striped bass (Morone saxatilis × M. chrysops) (Udomkusonsri et al 2004).…”

Section: Nervous and Sensory Systemsmentioning

confidence: 99%

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Morphologic Effects of the Stress Response in Fish

Harper

Wolf²

2009

ILAR Journal

178

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Fish and other aquatic animals are subject to a broad variety of stressors because their homeostatic mechanisms are highly dependent on prevailing conditions in their immediate surroundings. Yet few studies have addressed stress as a potential confounding factor for bioassays that use fish as test subjects. Common stressors encountered by captive fish include physical and mental trauma associated with capture, transport, handling, and crowding; malnutrition; variations in water temperature, oxygen, and salinity; and peripheral effects of contaminant exposure or infectious disease. Some stress responses are detectable through gross or microscopic examination of various organs or tissues; as reported in the literature, stress responses are most consistently observed in the gills, liver, skin, and components of the urogenital tract. In addition to presenting examples of various stressors and corresponding morphologic effects, this review highlights certain challenges of evaluating stress in fish: (1) stress is an amorphous term that does not have a consistently applied definition; (2) procedures used to determine or measure stress can be inherently stressful; (3) interactions between stressors and stress responses are highly complex; and (4) morphologically, stress responses are often difficult to distinguish from tissue damage or compensatory adaptations induced specifically by the stressor. Further investigations are necessary to more precisely define the role of stress in the interpretation of fish research results.

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Section: Hypoxiamentioning

confidence: 99%

Section: Nervous and Sensory Systemsmentioning

confidence: 99%

Morphologic Effects of the Stress Response in Fish

Harper

Wolf²

2009

ILAR Journal

178

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Apoptosis in fish: environmental factors and programmed cell death

et al. 2016

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Apoptosis, a form of programmed cell death, is a critical component in maintaining homeostasis and growth in all tissues and plays a significant role in immunity and cytotoxicity. In contrast to necrosis or traumatic cell death, apoptosis is a well-controlled and vital process characterized mainly by cytoplasmic shrinkage, chromatin condensation, DNA fragmentation, membrane blebbing and apoptotic bodies. Our understanding of apoptosis is partly based on observations in invertebrates but mainly in mammals. Despite the great advantages of fish models in studying vertebrate development and diseases and the tremendous interest observed in recent years, reports on apoptosis in fish are still limited. Although apoptotic machinery is well conserved between aquatic and terrestrial organisms throughout the history of evolution, some differences exist in key components of apoptotic pathways. Core parts of apoptotic machinery in fish are virtually expressed as equivalent to the mammalian models. Some differences are, however, evident, such as the extrinsic and intrinsic pathways of apoptosis including lack of a C-terminal region in the Fas-associated protein with a death domain in fish. Aquatic species inhabit a complex and highly fluctuating environment, making these species good examples to reveal features of apoptosis that may not be easily investigated in mammals. Therefore, in order to gain a wider view on programmed cell death in fish, interactions between the main environmental factors, chemicals and apoptosis are discussed in this review. It is indicated that apoptosis can be induced in fish by exposure to environmental stressors during different stages of the fish life cycle.

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Fish as model systems for the study of vertebrate apoptosis

Krumschnabel

Podrabsky

2008

Apoptosis

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Apoptosis is a process of pivotal importance for multi-cellular organisms and due to its implication in the development of cancer and degenerative disease it is intensively studied in humans and mammalian model systems. Invertebrate models of apoptosis have been well-studied, especially in C. elegans and D. melanogaster, but as these are evolutionarily distant from mammals the relevance of findings for human research is sometimes limited. Presently, a non-mammalian vertebrate model for studying apoptosis is missing. However, in the past few years an increasing number of studies on cell death in fish have been published and thus new model systems may emerge. This review aims at highlighting the most important of these findings, showing similarities and dissimilarities between fish and mammals, and will suggest topics for future research. In addition, the outstanding usefulness of fish as research models will be pointed out, hoping to spark future research on this exciting, often underrated group of vertebrates.

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Perinatal Hypoxia Induces Anterior Chamber Changes in the Eyes of Offspring Fish

Cited by 4 publications

References 35 publications

Morphologic Effects of the Stress Response in Fish

Morphologic Effects of the Stress Response in Fish

Apoptosis in fish: environmental factors and programmed cell death

Fish as model systems for the study of vertebrate apoptosis

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