Perinatal Infections in Ukraine: Results of a Multicenter Study

Abstract

The aim: To obtain the estimates of the сurrent incidence rate of perinatal infections, risk factors, as well as their associated impact on mortality and determine the antimicrobial resistance of responsible pathogens in Ukraine. Materials and methods: We performed a multicentre retrospective cohort study was based on surveillance data. This study included infants aged 0 to 6 days delivered in 2017-2019 at 11 Ukrainian regional perinatal centers. Definitions of perinatal infections and mortality were used from the CDC/WHO/UNICEF. Results: Of 18,348 liveborn infants, 472 (2.6%) perinatal infections were detected. The incidence of perinatal infection was 25.7 per 1000 live births. The most frequently identified types of infections were: bloodstream infections, 35.6 %, lower respiratory tract infections, 21.4%, Meningitis, 18.2%, Conjunctivitis, 11.9%, skin and soft tissue infections, 6.6%, Dacryocystitis, 3.8%, and urinary tract infections, 2.5%. Early mortality rates from perinatai infections was 51.1%, with an incidence of 13.1 deaths/1000 live births. Potential risk factors the development of perinatal infections and mortality were low birth weight, prematurity, low gestasional age, mode of delivery (manual aid), premature rupture of membranes, preterm premature rupture of membranes, prolonged rupture of membranes, turbid and meconeal amniotic fluid, infection of the mother during labor. resuscitation during delivery, invasive procedure, asphyxia. Main causative agents of perinatal infections were Escherichia coli, Streptococcus agalactiae, Staphylococcus aureus, Klebsiella pneumoniae, CoNS, Enterobacter cloacae, Pseudomonas aeruginosa. Conclusions: This study showing that the high incidence rate of perinatal bacterial infections, as well as their associated impact on mortality, and presents a significant burden to the Ukraine.

Systematic review of health and disease in Ukrainian children highlights poor child health and challenges for those treating refugees

“…One study reported that the most common agents for perinatal infections in newborn infants born in 2017–2019 in Ukraine were: Escherichia coli , Streptococcus agalactiae , Staphylococcus aureus , Klebsiella pneumoniae , Coagulase ‐ negative staphylococci , Enterobacter and Pseudomonas aeruginosa 99 …”

“…After duplicates were removed, the titles and abstracts of 1,628 reports were reviewed by one of the authors (JFL), and 131 met the eligibility criteria (Figure 1). The current review was primarily based on 107 full papers, 2‐108 but, due to the scarcity of data, we also chose to cite five relevant abstracts 109‐113 for a more complete picture of child health in Ukraine. Our literature search was limited to papers published in English.…”

Global Case Fatality of Bacterial Meningitis During an 80-Year Period

“…The design was observational in 330 studies (94%) and interventional in 20 (6%) studies, with 12 to 22 831 (median [IQR], 115 [61-270]) episodes per study, and the inclusion period’s length varying from 3 months to 36 years (median [IQR], 5 [2-10] years). Studies included neonates (59 studies [16%]; 6549 episodes [4%]), children (101 studies [27%]; 21 511 episodes [14%]), adults (64 studies [17%]; 15 362 episodes [10%]), neonates and children (68 studies [18%]; 26 992 episodes [17%]),…”

A study on the fine management mode of obstetric pregnancy drugs under the payment of disease diagnosis-related groups (DRG)

“…This is related to the speci city of drug use during pregnancy, and β-lactam antibiotics are relatively safe to use during pregnancy [6]. Optimizing the management and empiric antimicrobial therapy can reduce infections in pregnant women, such as the more common urinary tract infections, so prevention is still a key factor [7]. Although antimicrobial therapy may reduce preterm birth and low birth weight, consistent with the role of infection in adverse pregnancy outcomes, there is limited con dence in the effects given the uncertainty of the evidence.…”