2012
DOI: 10.3390/v4102359
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Perinatal Lamb Model of Respiratory Syncytial Virus (RSV) Infection

Abstract: Respiratory syncytial virus (RSV) is the most frequent cause of bronchiolitis in infants and children worldwide. Many animal models are used to study RSV, but most studies investigate disease in adult animals which does not address the unique physiology and immunology that makes infants more susceptible. The perinatal (preterm and term) lamb is a useful model of infant RSV disease as lambs have similar pulmonary structure including airway branching, Clara and type II cells, submucosal glands and Duox/lactopero… Show more

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Cited by 52 publications
(86 citation statements)
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“…The respiratory system of lambs and human infants share many anatomical, physiological and developmental features that increase the translational value of studies performed in lambs for inhaled drugs 15 20 Colostrum-deprived (lacking maternal antibody and thus any anti-RSV antibodies) neonatal lambs are highly relevant for the study of RSV infection due to their natural susceptibility to ovine, bovine and human strains of RSV 30-32 and to the similarities in disease pathogenesis to that of human infants 17 33 This lamb hRSV-infection model therefore constitutes a valuable tool for use in pre-clinical studies of vaccines or therapeutics.…”
Section: Discussionmentioning
confidence: 99%
“…The respiratory system of lambs and human infants share many anatomical, physiological and developmental features that increase the translational value of studies performed in lambs for inhaled drugs 15 20 Colostrum-deprived (lacking maternal antibody and thus any anti-RSV antibodies) neonatal lambs are highly relevant for the study of RSV infection due to their natural susceptibility to ovine, bovine and human strains of RSV 30-32 and to the similarities in disease pathogenesis to that of human infants 17 33 This lamb hRSV-infection model therefore constitutes a valuable tool for use in pre-clinical studies of vaccines or therapeutics.…”
Section: Discussionmentioning
confidence: 99%
“…Premature infants and preterm lambs have increased RSV disease severity compared with healthy adults, and the reason for this is not fully elucidated but likely multifactorial. 23,59,66,70,90 The newborn has fewer alveoli that have increased wall thickness compared with adult alveoli. This reduces the efficiency of gaseous exchange and may contribute to more severe clinical symptoms.…”
Section: Effector Cells Of Pulmonary Innate Immunity and Effects Of Agementioning
confidence: 99%
“…57 Submucosal gland expression and airway branching patterns of lambs are similar to those of infants. 23,122 The number and differentiation of Clara cells increase in the lung during fetal and perinatal development. 9,10 Clara cell CC10 protein is expressed as early as 10 weeks' gestation in humans 63 and consistently by 15 weeks' gestation.…”
Section: Effector Cells Of Pulmonary Innate Immunity and Effects Of Agementioning
confidence: 99%
“…As in the cotton rat model, virus replication does not induce significant disease, and symptoms tend to be mild or absent. Infection of neonatal lambs with RSV produces mild symptoms that include fever, tachypnea, and malaise as well as histologic lesions in lung tissue (27,30). However, the natural history of RSV infection in this model has not been fully characterized, and there are limited data on quantitative viral load measurements in tissues over the course of infection or on the development of techniques to quantify symptoms to correlate virus replication with disease progression.…”
mentioning
confidence: 99%
“…Thus, the cotton rat model is not suitable for measuring changes in disease pathogenesis resulting from antiviral therapy. Additional animal models have been developed using chimpanzees, African green monkeys, infant rhesus monkeys, and mice to study RSV infection (18,(26)(27)(28)(29). As in the cotton rat model, virus replication does not induce significant disease, and symptoms tend to be mild or absent.…”
mentioning
confidence: 99%