Perinatal maternal application of Lactobacillus rhamnosus GG suppresses allergic airway inflammation in mouse offspring

Abstract

Our data suggest that LGG may exert beneficial effects on the development of experimental allergic asthma, when applied in a very early phase of life. Immunological effects are, at least in parts, mediated via the placenta, probably by induction of pro-inflammatory cell signals.

Homage to the ‘H’ in developmental origins of health and disease

“…An earlier study with mice perinatally exposed to LGG yielded some similar but also notable cytokine differences. 65 In this report, TNF-α, IFN-γ, Il-5 (produced by Th2 cells and stimulates development of B-lymphocytes and increases immunoglobulin secretion) and Il10 (an antiinflammatory cytokine) are decreased in offspring derived from dams provided LGG. Another rat study suggests that maternal probiotic intervention decreases IFN-γ levels, upregulates Muc2 (produced by goblet cells and protein product helps contribute to mucous barrier overlying the intestinal epithelial cells) ileal gene expression in male offspring subjected to maternal separation but increases Il-6 in maternally separated pups.…”

“…At weaning, pups were either provided the same probiotic or it was discontinued Prenatal exposure to the probiotic supplement increased serum IgG, intestinal sIgA, and IFNγ in resulting offspring. All of these are considered inflammatory markers Prenatal probiotic supplementation resulted in enhanced antibody response to hepatitis-B surface antigen (HBsAg) 64 Male and female Swiss Albino mice Probiotic-containing milk (PFM) supplemented with L. rhamnosus was provided to dams during lactation and/or to their offspring after weaning PFM-exposed mice had greater leukocyte functionality, as shown by increased release of lysosomal enzymes (β-galactosidase and β-glucuronidase) and nitric oxide production Reduced levels of inflammatory markers (TNF-α, monocytic chemotactic protein-1) and allergic antibodies (total and milk specific IgE) were observed in offspring supplemented with PFM or where it was provided to the dams Other inflammatory markers (IFNγ and IL-4) were increased in offspring exposed to PFM 65 Male and female BALB/c mice Females received on an every other day basis LGG 10 days before conception and throughout gestation and lactation…”

Various effects of different probiotic strains in allergic disorders: an update from laboratory and clinical data

“…Atopic dermatitis (eczema) Sistek et al [31] Lctbs rhamnosus + Bfdbm lactis Food-sensitized atopic children ↓ Kalliomäki et al [45] Lactobacillus GG Atopic dermatitis ↓ Kopp et al [46] Lactobacillus GG Atopic dermatitis ↔, ↑ Wickens et al [47] Lctbs rhamnosus IgE-associated eczema ↓ Viljanen et al [41,48] LGG Atopic eczema/dermatitis syndrome ↓ Rosenfeldt et al [49] Lctbs rhamnosus + Lctbs reuteri Atopic dermatitis ↓ Kuitunen et al [50] Lctbs + Bfdbm + propionibacteria IgE-associated allergy ↓ Boyle et al [54] Various Eczema ↔ Lee et al [55] Various Atopic dermatitis ↔ Soh et al [63] Bfdbm longum + Lctbcs rhamnosus Eczema and atopic sensitization ↔ Food allergy and anaphylaxis Kim et al [27] Lctbs acidophilus + Bfdbm lactis OVA-induced allergic symptoms ↓ Isolauri et al [56] Bfdbm or Lctbs Food allergy ↓ Majamaa et al [57] LGG Food-sensitized eczema ↓ Shida et al [60] VSL#3 + Lctbs casei strain Shirota Anaphylaxis with food allergy ↓ Hol et al [61] Lctbs casei + Bfdbm Bb-12 Cow's milk allergy ↔ Taylor et al [62] LGG or Lctbs acidophilus Cow's milk allergy ↔, ↑ Allergic rhinitis Di Felice et al [59] VSL#3 Allergic rhinitis ↓ Giovannini et al [67] Lctbs casei Allergic rhinitis ↓ Morita et al [69] LGG + Lctbs gasseri Allergic rhinitis ↓ Xiao et al [71] Bfdbm longum Allergic rhinitis; JCP ↓ Tamura et al [72] Lctbs casei strain Shirota Allergic rhinitis; JCP ↔ Asthma Kruisselbrink et al [33] Lctbs plantarum Dermatophagoides (Der p1) sensitization ↓ Feleszko et al [43] Bfdbm-12 Airway reactivity ↓ Blümer et al [73] LGG Allergic asthma ↓ Repa et al [74] Lactococcus lactis + Lctbs plantarum Birch pollen allergen (Bet v1) sensitization ↓ Karimi et al [75] Lctbs reuteri Allergic airway inflammation ↓ Helin et al [78] LGG Pollen allergy ↔ ↑: Increase in symptoms or negative effect; ↓: decrease in symptoms or positive effect; ↔: no change in symptoms or no effect; Bfdbm: Bifidobacterium; JCP: Japanese cedar pollinosis; Lctbs: Lactobacillus; LGG: Lctbs rhamnosus GG; VSL#3: probiotic mixture; OVA: ovalbumin.…”

Dietary or Supplementary Intake Modulates Inflammatory Response in Asthma Response in Asthma

“…Oral treatment with probiotics reduces allergic symptoms in ovalbumin-sensitized mice [62]. Perinatal Lactobacillus rhamnosus GG (LGG) supplementation has beneficial effects on the development of allergic asthma in offspring [63]. Oral treatment with LGG prior to sensitization attenuated airway inflammation and hyperreactivity in a mouse model of allergic airway inflammation [64].…”