Perinatal mortality and congenital anomalies in babies of women with type 1 or type 2 diabetes in England, Wales, and Northern Ireland: population based study

Macintosh, M. C. M.; Fleming, Kate M; Bailey, Jaron A; Doyle, Pat; Modder, Jo; Acolet, Dominique; Golightly, S; Miller, Alison

doi:10.1136/bmj.38856.692986.ae

Cited by 606 publications

(412 citation statements)

References 28 publications

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“…A systematic review examining the causes of stillbirth reported that chronic hypertension is associated with an increased risk with odds ratios of 1.5–2.7 [24]. Similarly, a UK national population-based cohort study of 2,359 pregnancies in women with diabetes mellitus reported a twofold increase in the risk of stillbirth compared to non-diabetic women [25]. A US population-based study reported that in pregnancies with preeclampsia the risk of stillbirth is increased by 70% [26].…”

Section: Discussionmentioning

confidence: 99%

Birthweight with Gestation and Maternal Characteristics in Live Births and Stillbirths

et al. 2012

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Objective: To establish a normal range of birthweight with gestational age (GA) at delivery and examine the contribution of maternal characteristics in defining growth restriction in stillbirths. Methods: In 69,895 normal singleton pregnancies, regression analysis was used to determine the association of birthweight with GA and maternal characteristics. The proportion of 290 stillbirths classified as small for GA depending on inclusion or exclusion of maternal characteristics was determined. Results: In normal pregnancies, there was a polynomial association between birthweight and GA. Birthweight increased with maternal weight, height and parity and was lower in Africans and South Asians than in Caucasians. Birthweight for GA was reduced in antepartum stillbirths (n = 243; p < 0.0001) but not in intrapartum stillbirths (n = 47; p = 0.334). There was no significant difference in the proportion of antepartum stillbirths with birthweight below the 10th percentile when birthweight was corrected for GA only compared to correction for GA and maternal characteristics (53.1 vs. 54.3%). The birthweight was below the 10th percentile in 71.8% of antepartum stillbirths at <32 weeks’ gestation, in 47.2% at 33–36 weeks and in 31.5% at ≥37 weeks. Conclusion: Correction of birthweight for maternal characteristics does not alter the proportion of stillbirths that are small for GA.

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Section: Discussionmentioning

confidence: 99%

Birthweight with Gestation and Maternal Characteristics in Live Births and Stillbirths

et al. 2012

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“…Autoimmunologische Erkrankungen, wie das 7 Antiphospholipid-Syndrom, oder Erkrankungen, die mit einer Arteriosklerose einhergehen, sind hierfür Beispiele. Populationsbasierte Untersuchungen weisen bei Diabetes mellitus und arterieller Hypertonie auf eine Erhöhung des Risikos für eine Totgeburt um den Faktor 2-4 hin [10]. Die Assoziation von Thrombophilien mit Spätabort und intrauterinem Fruchttod zeigt .…”

Section: Cme (Weitgehend) Sichere Ursachen Für Totgeburtenunclassified

Totgeburt und plötzlicher Kindstod

Beinder¹,

Bucher²

2008

Gynäkologe

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ZusammenfassungDie Totgeburtenrate hat in entwickelten Ländern in den letzten 30 Jahren im Gegensatz zur neonatalen Sterblichkeit und der Häufigkeit des plötzlichen Kindstodes kaum abgenommen. Dies ist verwunderlich, da heute weit weniger Totgeburten aufgrund einer Plazentainsuffizienz, eines maternalen Diabetes mellitus, einer Präeklampsie, oder durch Rhesusinkompatibilität und fetale Aneuploidien auftreten. Dagegen steigt die Rate an ätiologisch ungeklärten Fällen von Totgeburten an. Die eindrücklichen Erfolge in der Prävention des plötzlichen Kindstods zeigen, dass auch ätio-logisch ungeklärte Erkrankungen wirkungsvoll verhindert werden können. Rauchen und Adipositas, sowie übermäßige Gewichtszunahme als Risikofaktoren für den intrauterinen Fruchttod sind vor Eintritt der Schwangerschaft modifizierbar. Die Erkennung und Therapie von Diabetes mellitus, Gestationsdiabetes und arterieller Hypertonie sind effektive Maßnahmen in der Schwangerschaft zur Verringerung von Totgeburten. Die Geburtseinleitung am Termin wäre ebenfalls eine effektive Methode zur Vermeidung von Totgeburten, wobei für eine vermiedene Totgeburt etwa 300 Geburtseinleitungen mit den damit verbundenen Nachteilen notwendig wären. Schlüsselwörter Intrauteriner Fruchttod · Plötzlicher Kindstod · Perinatale Sterblichkeit Stillbirth and sudden infant death syndrome · Common factors and differences AbstractDuring the last 30 years the rate of stillbirths in industrial countries has remained nearly identical, while neonatal mortality und the incidence of the sudden infant death syndrome (SIDS) has declined significantly. This observation is in contrast to the decline of stillbirths due to placental insufficiency, maternal diabetes mellitus, preeclampsia, rhesus incompatibility and fetal aneuploidy. However, the incidence of unexplained stillbirths has increased. The decrease of the incidence of the sudden infant death syndrome proves that prevention of diseases of unknown origin is possible. Smoking, obesity and an excessive increase in body weight before pregnancy are modifiable risk factors for intrauterine stillbirth. The detection and treatment of diabetes mellitus, gestational diabetes and arterial hypertension are effective measures in pregnancy to reduce the risk for stillbirth. The induction of labor at term is also effective in the reduction of stillbirths, however, the burden of elective induction with all of the possible negative effects has to be balanced against the benefit of avoiding intrauterine deaths as approximately 300 labor inductions with the corresponding disadvantages, would be necessary to avoid 1 stillbirth.

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“…Sacral agenesis and caudal regression syndrome is almost pathognomonic of diabetes and occurs 256 times more often in diabetic than non-diabetic 13 .…”

Section: Introductionmentioning

confidence: 99%

Congenital Anomalies among the Babies of Diabetic Mothers with Uncontrolled Blood Sugar -A Study in a Tertiary Hospital

Taslima¹

2017

Med. Today

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Perinatal mortality and congenital anomalies in babies of women with type 1 or type 2 diabetes in England, Wales, and Northern Ireland: population based study

Abstract: Objective To provide perinatal mortality and congenital anomaly rates for babies born to women with type 1 or type 2 diabetes in England, Wales, and Northern Ireland.

Cited by 606 publications

References 28 publications

Birthweight with Gestation and Maternal Characteristics in Live Births and Stillbirths

Birthweight with Gestation and Maternal Characteristics in Live Births and Stillbirths

Totgeburt und plötzlicher Kindstod

Congenital Anomalies among the Babies of Diabetic Mothers with Uncontrolled Blood Sugar -A Study in a Tertiary Hospital

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