Perinatal outcome in children born after assisted reproductive technologies

Wennerholm, Ulla‐Britt; Bergh, Christina

doi:10.1080/03009734.2020.1726534

Cited by 45 publications

(36 citation statements)

References 78 publications

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“…In our study, the newborn birth weight increased by 23.837 g for each additional day of pregnancy. Moreover, pregnancy complications and abnormal function of fetal appendages may affect the blood circulation between the mother and child during pregnancy, thereby leading to adverse neonatal outcomes [22]. The regression analysis in our study revealed that hypertension during pregnancy, premature rupture of membranes, and placenta previa were independent risk factors for decreased newborn birth weight.…”

Section: Discussionmentioning

confidence: 53%

A thinner endometrium is associated with lower newborn birth weight during in vitro fertilization–frozen-embryo transfer: cohort study

Zhang

Luo

Han

et al. 2021

Preprint

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BackgroundThe purpose of this study is to explore the influence of endometrial thickness (EMT) before embryo transfer on birth weight after in vitro fertilization–frozen-embryo transfer (IVF–FET).MethodsThis was a retrospective cohort study. We collected the medical records associated with singleton live births from Tianjin Central Obstetrics and Gynecology Hospital from June 2015 to February 2019 after IVF–frozen-embryo transfer (FET). Patients were ≤ 42 years at delivery. Outcomes related to newborns were birth weight, gestational age, delivery mode, low birth weight, and prevalence of macrosomia. Outcomes related to pregnant women were gestational hypertension, gestational diabetes mellitus, premature rupture of membranes and placenta previa.ResultsThe birth weight of singleton newborns was higher for newborns delivered by patients with EMT > 12 mm before embryo transfer than newborns delivered by patients with a thinner endometrium. Regression analysis showed that the EMT ≥ 12 mm group had a gain in mean birth weight of 85.107 g compared with that in the EMT < 8 mm group, whereas the group with EMT of 8–12 mm had an increase in mean birth weight of 25.942 g compared with that in the EMT < 8 mm group. Hypertension during pregnancy, premature rupture of membranes, placenta previa, newborn sex, gestational age, delivery mode, number of implanted embryos, follicle-stimulating hormone (FSH) level, estradiol (E2) level, and pre-pregnancy body mass index (BMI) were all independent predictors of newborn birth weight. The regression model for predicting the newborn birth weight was: Y (birth weight) = 25.942×(EMT of 8–12 mm) + 85.107×(EMT > 12 mm) + 123.483×(hypertension during pregnancy) + 148.859×(premature rupture of membranes) + 182.342×(placental position) − 126.242×(newborn sex) + 23.837×(number of days of pregnancy) + 130.487×(delivery mode) − 55.023×(number of implanted embryos) − 6.215×FSH level − 1.124×E2 level + 22.218×BMI − 4468.101.Conclusion(s)EMT before embryo transfer in patients undergoing their first freeze–thaw embryo transfer cycle is related to the weight of newborn singletons. The newborn birth weight for patients with a thinner endometrium is lower. EMT should be increased before embryo transfer to improve neonatal outcomes after fertility treatment.

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Section: Discussionmentioning

confidence: 53%

A thinner endometrium is associated with lower newborn birth weight during in vitro fertilization–frozen-embryo transfer: cohort study

Zhang

Luo

Han

et al. 2021

Preprint

View full text Add to dashboard Cite

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“…Stillbirths are also increased among all twins, but 3–6 times higher than background in MZ twins (Glinianaia et al, 2011; Lewi et al, 2013). Even at the time of birth, all twins, but particularly MZ twins, are more likely to be premature, have intrauterine growth restriction, and experience maternal complications (Wennerholm & Bergh, 2020).…”

Section: Loss Of Mz Twins Early In Pregnancymentioning

confidence: 99%

The mystery of monozygotic twinning II: What can monozygotic twinning tell us about Amyoplasia from a review of the various mechanisms and types of monozygotic twinning?

Hall

2021

American J of Med Genetics Pt A

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Monozygotic (MZ) twins (“identical twins”) are essentially unique to human beings. Why and how they arise is not known. This article reviews the possible different types of MZ twinning recognized in the previous article on twins and arthrogryposis. There appear to be at least three subgroups of MZ twinning: spontaneous, familial, and those related to artificial reproductive technologies. Each is likely to have different etiologies and different secondary findings. Spontaneous MZ twinning may relate to “overripe ova.” Amyoplasia, a specific nongenetic form of arthrogryposis, appears to occur in spontaneous MZ twinning and may be related to twin–twin transfusion.

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“…The mechanisms by which congenital anomalies occur in these patients are not completely elucidated but it is considered that certain procedures used in assisted reproduction contribute to this risk. Some studies show that intracytoplasmic sperm insemination (ICSI) increases the risk of congenital anomalies more than in vitro fertilization (IVF) [ 12 , 13 ]. The association between ICSI and the risk of malformations has been shown to be closely linked to male subfertility [ 14 , 15 ].…”

Section: Risk Of Congenital Anomalies In Art Pregnanciesmentioning

confidence: 99%

“…Congenital anomalies reported in the ART population involve damage to the central nervous system, cardiovascular, genitourinary system, but also the auditory and visual system [ 13 ].…”

Section: Eye Abnormalities Associated With the Use Of Artmentioning

confidence: 99%

Eye anomalies in children born through ART

Bănică

Popescu

Vlădăreanu

2021

rjo

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Due to the increasing rate of couples suffering from infertility, recently, the use of assisted reproductive technology (ART) has increased by 5%–10% per year. Some ART pregnancies are at risk of obstetric and neonatal complications, but it is unknown whether the procedures used or the etiology of infertility influences this risk. Multiple ART pregnancies are responsible for the increased rate of prematurity and its associated complications. Also, it has been demonstrated that ART pregnancies have a higher risk of congenital anomalies. The rate of ART-associated ocular abnormalities is incompletely known due to a small number of studies conducted regarding this pathology. In this paper, we presented a review of literature on ocular anomalies associated with ART in order to raise awareness of the need to implement ophthalmological screening in children from pregnancies obtained by ART. Abbreviations: ART = assisted reproductive techniques, IVF = in vitro fertilization, ICSI = intracytoplasmic sperm injection, LBW = low birth weight, ROP = retinopathy of prematurity

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Perinatal outcome in children born after assisted reproductive technologies

Cited by 45 publications

References 78 publications

A thinner endometrium is associated with lower newborn birth weight during in vitro fertilization–frozen-embryo transfer: cohort study

A thinner endometrium is associated with lower newborn birth weight during in vitro fertilization–frozen-embryo transfer: cohort study

The mystery of monozygotic twinning II: What can monozygotic twinning tell us about Amyoplasia from a review of the various mechanisms and types of monozygotic twinning?

Eye anomalies in children born through ART

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