Perinatal Outcome in Gestational Diabetes Melitus Vs Normoglycemic Women

Krstevska, Slagjana Simeonova; Samardziski, Igor; Bosku, Aleksandra Atanasova; Todorovska, Irena; Sima, Aneta; Livrinova, Vesna; Jovanovska, Viktorija; Milkovski, Daniel; Nakova, Valentina Velkoska

doi:10.26717/bjstr.2020.26.004338

Cited by 3 publications

(6 citation statements)

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“…While studies reported higher risks of preterm [ 49 ], macrosomia [ 8 ] and high birthweight [ 50 ] births in GDM, we did not observe these associations in SBC and GUSTO cohorts. This may be explained by effective dietary interventions as women in both cohorts attended prenatal care in high-quality tertiary care centers.…”

Section: Discussioncontrasting

confidence: 99%

Comparative epidemiology of gestational diabetes in ethnic Chinese from Shanghai birth cohort and growing up in Singapore towards healthy outcomes cohort

Zhang

Yap

et al. 2021

BMC Pregnancy Childbirth

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Background Gestational diabetes mellitus (GDM) has been associated with adverse health outcomes for mothers and offspring. Prevalence of GDM differs by country/region due to ethnicity, lifestyle and diagnostic criteria. We compared GDM rates and risk factors in two Asian cohorts using the 1999 WHO and the International Association of Diabetes and Pregnancy Study Groups (IADPSG) criteria. Methods The Shanghai Birth Cohort (SBC) and the Growing Up in Singapore Towards healthy Outcomes (GUSTO) cohort are prospective birth cohorts. Information on sociodemographic characteristics and medical history were collected from interviewer-administered questionnaires. Participants underwent a 2-h 75-g oral glucose tolerance test at 24–28 weeks gestation. Logistic regressions were performed. Results Using the 1999 WHO criteria, the prevalence of GDM was higher in GUSTO (20.8%) compared to SBC (16.6%) (p = 0.046). Family history of hypertension and alcohol consumption were associated with higher odds of GDM in SBC than in GUSTO cohort while obesity was associated with higher odds of GDM in GUSTO. Using the IADPSG criteria, the prevalence of GDM was 14.3% in SBC versus 12.0% in GUSTO. A history of GDM was associated with higher odds of GDM in GUSTO than in SBC, while being overweight, alcohol consumption and family history of diabetes were associated with higher odds of GDM in SBC. Conclusions We observed several differential risk factors of GDM among ethnic Chinese women living in Shanghai and Singapore. These findings might be due to heterogeneity of GDM reflected in diagnostic criteria as well as in unmeasured genetic, lifestyle and environmental factors.

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Section: Discussioncontrasting

confidence: 99%

Comparative epidemiology of gestational diabetes in ethnic Chinese from Shanghai birth cohort and growing up in Singapore towards healthy outcomes cohort

Zhang

Yap

et al. 2021

BMC Pregnancy Childbirth

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“…Study in the USA demonstrated that 1.5–4% of newborns from mothers with GDM developed RDS [ 78 ]. Similarly, previous studies also shown that infants from women with GDM had higher risk of developing RDS [ 74 , 75 , 87 ]. This might be associated with the effects of hyperglycemia delays fetal lung maturity.…”

Section: Discussionsupporting

confidence: 59%

“…The pooled prevalence of preterm birth among mothers with HIP was 16.9%. Previous reports also demonstrated this higher risk of prematurity among women with GDM [ 75 , 78 , 83 , 87 ]. This high risk of prematurity might be associated with early induction of labor before 39 weeks of gestation and/or premature rupture of membranes [ 79 ].…”

Section: Discussionsupporting

confidence: 56%

“…A systematic review and meta-analysis in SSA [ 16 ], South Asia [ 76 ], and Turkey [ 57 ] revealed that GDM was associated with an increased risk of pregnancy-induced hypertension among pregnant mothers. It has been reported that women with HIP are at greater risk for pre-eclampsia [ 2 , 87 , 93 , 94 ]. Even mild HIP is associated with a significantly higher risk of HDP [ 95 ].…”

Section: Discussionmentioning

confidence: 99%

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Epidemiology of hyperglycemia during pregnancy in Ethiopia: prevalence, associated factors, and feto-maternal outcomes: systematic review and meta-analysis

Tola,

Assefa,

Dessie

et al. 2024

Syst Rev

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Background Hyperglycemia in pregnancy (HIP) is a significant medical complication affecting pregnant women globally and is considered a public health burden due to the negative outcomes it can cause for both mother and infant. The aim of this systematic review and meta-analysis was to examine the prevalence, risk factors, and feto-maternal outcomes of HIP in Ethiopia. Methods To gather relevant information for this study, both published and unpublished studies were searched for in several major databases, including PubMed, Embase, HINARI, Web of Science direct, and Google Scholar, as well as other sources. The Joanna Briggs Institute (JBI) tool was used to evaluate the methodological quality of the findings from these studies. Data was then extracted and summarized using a template in Microsoft Excel software, and the extracted data was analyzed using Stata software version 16.0. If significant heterogeneity was found between studies, subgroup analyses were conducted to further examine the data. Result Eighteen studies were included in this systematic review and meta-analysis, involving a total sample size of 50,816 pregnant women in Ethiopia. The prevalence of HIP among pregnant women varied considerably across the primary studies, ranging from 0.4 to 26.2%. The pooled prevalence of HIP among pregnant women in Ethiopia was found to be 6.9% (95% C 2.2–11.6). Pregnant women with a family history of diabetes had 2.5 times higher odds of developing HIP compared to those without a family history of diabetes (OR = 2.49; 95% CI = 2.02, 2.96). However, there was no significant association found between HIP and maternal obesity (OR 2.31, 95% CI = 0.85, 3.78) or previous history of abortion (OR 3.89; 95% CI 0.85, 6.94). The common fetal outcomes associated with HIP were admission to the intensive care unit (46.2; 95% CI 27.4, 65.1), macrosomia (27.3%; 95% CI 9.4%, 45.1%), and preterm birth (16.9; 95% CI 12.5, 21.3). Additionally, hypertensive disorders of pregnancy (28.0%; 95% CI 15.2, 40.8) and operative delivery (51.4%; 95% CI 35.9, 66.8) were more common among women with HIP in Ethiopia. Conclusion Although there was some variation between studies, the meta-analysis revealed that approximately seven out of 100 pregnant women in Ethiopia had HIP. A family history of diabetes was found to be a significant predictor of HIP in Ethiopia. Additionally, HIP was associated with various serious adverse outcomes for both mothers and infants in Ethiopia. These findings highlight the need for national guidelines to ensure that pregnant women are uniformly screened for HIP.

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“…5 GDM presents immediate risks to maternal health including increased likelihood of pre-term labour and developing hypertensive disorders of pregnancy, and in the infant a higher risk such as being born large for gestational age and shoulder dystocia. [6][7][8] Long-term impacts include increased risk of developing type 2 diabetes mellitus (T2DM) in later life for the mother, and infants exposed to GDM in-utero are more likely to develop obesity. 9 10 Gestational weight gain (GWG) is essential to support pregnancy, the National Academy of Medicine (NAM) published guidelines for a maximum GWG per week, dependent on the women's preconception BMI.…”

Section: Strengths and Limitations Of This Studymentioning

confidence: 99%

Differential effects of diet and physical activity interventions in pregnancy to prevent gestational diabetes mellitus and reduce gestational weight gain by level of maternal adiposity: a protocol for an individual patient data (IPD) meta-analysis of randomised controlled trials

et al. 2023

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IntroductionWomen and their infants are at increased risk of complications if gestational diabetes mellitus (GDM) or excessive gestational weight gain (GWG) occurs in pregnancy. Weight management interventions in pregnancy, consisting of diet and physical activity components are targeted based on maternal body mass index (BMI). However, the relative effectiveness of interventions targeted based on alternative measures of adiposity to BMI is unclear. This individual patient data (IPD) meta-analysis aims to explore whether interventions are more effective at preventing GDM and reducing GWG in women according to their level of adiposity.MethodsThe International Weight Management in Pregnancy Collaborative Network has a living database of IPD from randomised trials of diet and/or physical activity interventions in pregnancy. This IPD meta-analysis will use IPD from trials identified from systematic literature searches up until March 2021, where maternal adiposity measures (eg, waist circumference) were collected prior to 20 weeks’ gestation. A two-stage random effects IPD meta-analysis approach will be taken for each outcome (GDM and GWG) to understand the effect of early pregnancy adiposity measures on the effect of weight management interventions for GDM prevention and GWG reduction. Summary intervention effects with 95% CIs) will be derived along with treatment covariate interactions. Between-study heterogeneity will be summarised by I2and tau2statistics. Potential sources of bias will be evaluated, and the nature of any missing data will be explored and appropriate imputation methods adopted.Ethics and disseminationEthics approval is not required. The study is registered on the International Prospective Register of Systematic Reviews (CRD42021282036). Results will be submitted to peer-reviewed journals.PROSPERO registration numberCRD42021282036.

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Perinatal Outcome in Gestational Diabetes Melitus Vs Normoglycemic Women

Cited by 3 publications

References 8 publications

Comparative epidemiology of gestational diabetes in ethnic Chinese from Shanghai birth cohort and growing up in Singapore towards healthy outcomes cohort

Comparative epidemiology of gestational diabetes in ethnic Chinese from Shanghai birth cohort and growing up in Singapore towards healthy outcomes cohort

Epidemiology of hyperglycemia during pregnancy in Ethiopia: prevalence, associated factors, and feto-maternal outcomes: systematic review and meta-analysis

Differential effects of diet and physical activity interventions in pregnancy to prevent gestational diabetes mellitus and reduce gestational weight gain by level of maternal adiposity: a protocol for an individual patient data (IPD) meta-analysis of randomised controlled trials

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