Perinatal outcome of congenital heart disease in a population with high consanguinity

Hamdan, Mohamed A.; Chedid, Fares; Bekdache, G. N.; Begam, M.; Alsafi, Walaa; Sabri, Zainab; Mirghani, H.

doi:10.1515/jpm-2014-0019

Cited by 7 publications

(8 citation statements)

References 34 publications

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“… 8 On a regional level, the increased risk for congenital anomalies secondary to consanguinity has already been observed from recent Middle-Eastern and North African studies with similarly high incidence of consanguineous marriages. 9 – 11 The present findings are no exception, with a rate of consanguinity of almost 40% for the congenital anomalies cohort.…”

Section: Discussionsupporting

confidence: 51%

Prevalence of major congenital anomalies at King Fahad Medical City in Saudi Arabia: a tertiary care centre-based study

Sallout

Obedat

Shakeel³

et al. 2015

Annals of Saudi Medicine

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BACKGROUND AND OBJECTIVESThe prevalence of major congenital anomalies in Saudi Arabia is a largely understudied area. Knowing the prevalence of birth defects and their trends is important in identifying potential factors that are either causative or preventative. Early antenatal diagnosis of major congenital anomalies is important for possible termination of pregnancy, fetal or neonatal. We determined the prevalence of major congenital anomalies in our hospital population since implementation of an improved screening system.PATIENTS AND METHODSThis single-centre prospective cross-sectional study was conducted in a tertiary care hospital in Riyadh. A total of 63 452 obstetrical ultrasound examinations were performed for 30 632 female Saudi obstetric patients from the period of January 2007 to December 2012.RESULTSA total of 1598 fetuses were diagnosed with major congenital anomalies, including 1064 (66.6 %) fetuses with isolated major anomalies and 534 (33.4%) fetuses with non-isolated major anomalies. The antenatal prevalence of congenital anomalies was 52.1 per 1000 pregnancies. The median maternal age at diagnosis was 29 years. The median gestational age at diagnosis was 30 weeks of gestation. Two hundred and eighty five cases (17.85%) had a previous family history of similar anomalies. The most commonly diagnosed anomalies involved the genitourinary system (652 cases). The birth prevalence of major congenital anomalies was 46.5 per 1000 live births.CONCLUSIONThe prevalence of major congenital anomalies in our hospital population appears to be higher than international prevalences, with a high recurrence rate. Environmental, nutritional and social factors may be contributing to this phenomenon.

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Section: Discussionsupporting

confidence: 51%

Prevalence of major congenital anomalies at King Fahad Medical City in Saudi Arabia: a tertiary care centre-based study

Sallout

Obedat

Shakeel³

et al. 2015

Annals of Saudi Medicine

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“…22 The primary factors that affect the prevalence of fetal anomalies in different populations are consanguinity, use of assisted reproduction techniques, tobacco exposure, air pollution, water contamination and pesticide and agrochemical exposure. [23][24][25][26][27][28] The rates of consanguinity and smoking described in Brazilian populations have been lower than those in other countries. 22,29 We postulate that the higher prevalence of structural defects observed in the present study (higher than observed in North America, Europe and Saudi Arabia) may have arisen through assessment of cases referred to a tertiary-level healthcare center, instead of cases within a general population.…”

Section: Discussionmentioning

confidence: 95%

Fetal structural anomalies diagnosed during the first, second and third trimesters of pregnancy using ultrasonography: a retrospective cohort study

et al. 2019

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BACKGROUND: The prevalence of congenital abnormalities in general populations is approximately 3-5%. One of the most important applications of obstetric ultrasound is in detection of fetal structural defects. OBJECTIVE: To assess fetal structural anomalies diagnosed using ultrasound in the three trimesters of pregnancy. DESIGN AND SETTING: Retrospective cohort study at the Mário Palmério University Hospital of the University of Uberaba (Universidade de Uberaba, UNIUBE), from March 2014 to December 2016. METHODS: Ultrasound data at gestational weeks 11-13 + 6, 20-24 and 32-36 were recorded to identify fetal anomalies in each trimester and in the postnatal period. The primary outcome measurements were sensitivity, specificity, positive predictive value and negative predictive value for detection of fetal anomalies and their prevalence. RESULTS: The prevalence of anomalies detected using ultrasound was 2.95% in the prenatal period and 7.24% in the postnatal period. The fetal anomalies most frequently diagnosed using ultrasound in the three trimesters were genitourinary tract anomalies, with a prevalence of 27.8%. Cardiac anomalies were diagnosed more often in the postnatal period, accounting for 51.0% of all cases. High specificity, negative predictive value and accuracy of ultrasound were observed in all three trimesters of pregnancy. CONCLUSION: Ultrasound is safe and has utility for detecting fetal anomalies that are associated with high rates of morbidity and mortality. However, the low sensitivity of ultrasound for detecting fetal anomalies in unselected populations limits its utility for providing reassurance to examiners and to pregnant women with normal results.

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“…Previous studies also reported that the rate of kinship relationships among the parents of CA-afflicted infants was 58.5% in Birjand (28) and 40% in Saudi Arabia (28). Studies in the Middle East and North Africa also confirmed the greater risk of CAs among parents with consanguineous marriage (6,(35)(36)(37)(38). Moreover, a study in Ardebil reported a significant correlation between parental kinship relationship and CA affliction among infants (10).…”

Section: Discussionmentioning

confidence: 85%

The Prevalence of Major Congenital Anomalies Among Live Births in Birjand, Iran

2018

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Background and Objectives: Congenital anomalies can increase the neonatal mortality rate. Infants with anomalies suffer from long-term disabilities that impose heavy burdens on their families and healthcare systems. Understanding the prevalence of congenital anomalies helps health policy-makers develop better health-related policies. This study aimed to evaluate the prevalence of major congenital anomalies among live births in Birjand city, Iran. Methods: This cross-sectional descriptive-analytical study was conducted on 6,000 infants who were born from September 23, 2015, to March 6, 2016, in the maternity departments in Birjand. Stillbirths and infants who died immediately after birth, i.e. before the assessment for anomalies, were excluded. On the first day of birth, a neonatologist or a pediatrician performed a careful physical examination for each infant to diagnose probable congenital anomalies. Appropriate diagnostic procedures were also used to confirm the diagnosis when needed. Then, data on the characteristics of infants were collected using a researcher-made checklist. The data were reported using descriptive statistics such as absolute frequency, relative frequency, mean, and standard deviation. Moreover, the Chi-square and Fisher's exact tests were conducted using the SPSS computer program (v. 16.0) for hypothesis testing at a significance level of less than 0.05. Results: The prevalence of major congenital anomalies was 1.83 cases per 1000 live births. The prevalence rates of low birth weight and prematurity were significantly greater among infants with congenital anomalies than in their non-afflicted counterparts (45.5% vs. 15.9% and 36.4% vs. 11.1%, respectively; P < 0.05). Around 63.6% of the anomalies were among male infants and 54.5% of parents had kinship relationships. Conclusions: This study showed that the prevalence of major congenital anomalies among live births in Birjand was 1.83 cases per 1000 live births, which is less than the rates reported in other areas of Iran.

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Perinatal outcome of congenital heart disease in a population with high consanguinity

Abstract: Joint FE clinics detect most CHD with high accuracy. Consanguinity contributes to a higher prevalence of fetal cardiac and non-cardiac malformations. The presence of extracardiac anomalies is associated with an increase in perinatal mortality.

Cited by 7 publications

References 34 publications

Prevalence of major congenital anomalies at King Fahad Medical City in Saudi Arabia: a tertiary care centre-based study

Prevalence of major congenital anomalies at King Fahad Medical City in Saudi Arabia: a tertiary care centre-based study

Fetal structural anomalies diagnosed during the first, second and third trimesters of pregnancy using ultrasonography: a retrospective cohort study

The Prevalence of Major Congenital Anomalies Among Live Births in Birjand, Iran

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