Perinatal outcomes following labor induction with dinoprostone in pregnancies with borderline amniotic fluid index at term: A clinical observation study

Yin, Heng; Zhao, Lei; Lin, Yu-Cheng; Wang, Ying; Hu, Yaping; Sun, Guoqiang; Xiao, Mei

doi:10.1111/jog.13682

Cited by 2 publications

(2 citation statements)

References 32 publications

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“…Increased uterine blood flow and amplified estrogen-induced vasodilation are the effects of sildenafil citrate (15).…”

Section: Introductionmentioning

confidence: 99%

The Effect of Sildenafil Citrate on Improving Amniotic Fluid Index in Pregnant Women with Oligohydramnios and Borderline Oligohydramnios: A Randomized Controlled Trial

Nasrolahi,

Talebi-Ghane,

Torkashvand

2023

J Kermanshah Univ Med Sci

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Background: Oligohydramnios is a common problem in pregnancy that requires therapeutic measures in addition to managing the underlying cause. Objectives: This study aimed to assess sildenafil citrate’s impact on the amniotic fluid index in pregnant women with oligohydramnios and borderline oligohydramnios. Methods: Women with a singleton pregnancy, oligohydramnios, and gestational age of 24 to 36 weeks were included. Patients were randomly divided into two groups. The intervention group also received 50 mg of sildenafil citrate every 8 hours and 3 liters of isotonic solution per day. In the control group, a placebo was given along with hydration therapy, similar to the intervention groups. The amount of amniotic fluid was reassessed one week and two weeks after treatment. Weekly measurements of amniotic fluid volume, biophysical profile, and non-stress test were used twice a week for fetal monitoring. This study analyzed the data using SPSS version 23 with a significance threshold of P ≤ 0.05. Results: Finally, there was a substantial change in the amniotic fluid level between the basic and end of the second week (P ≤ 0.05). There was no apparent distinction between the two groups regarding pharmaceutical side effects or the consequences of pregnancy. Conclusions: Sildenafil citrate enhanced amniotic fluid production, although no significant issues were seen for the mother or fetus.

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“…Increased uterine blood flow and amplified estrogen-induced vasodilation are the effects of sildenafil citrate (15).…”

Section: Introductionmentioning

confidence: 99%

The Effect of Sildenafil Citrate on Improving Amniotic Fluid Index in Pregnant Women with Oligohydramnios and Borderline Oligohydramnios: A Randomized Controlled Trial

Nasrolahi,

Talebi-Ghane,

Torkashvand

2023

J Kermanshah Univ Med Sci

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“…Pregnancy-induced hypertension (PIH) is one of the most common complications in pregnancy [1]. Epidemiological statistics show that the incidence of PIH in the world has reached 10%, and it seriously threatens the health of pregnant women and perinatal infants [2,3]. With the increase of age and obesity of mothers in recent years, the incidence of PIH is gradually rising [4].…”

Section: Introductionmentioning

confidence: 99%

MicroRNA-378 protects human umbilical vein endothelial cells from injuries by soluble CD226 through down-regulating the expression of soluble CD226 in natural killer cells

et al. 2019

Biotechnology & Biotechnological Equipment

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This study aimed to determine the expression of microRNA (miRNA or miR)-378 in peripheral blood from patients with pregnancy-induced hypertension (PIH), and to try to understand its effect on vascular endothelial injuries induced by PIH. The study included 33 PIH patients. Quantitative real-time polymerase chain reaction was used to determine the expression of miR-378 in peripheral blood and NK cells. NK cells were transfected with miR-378 mimics and its negative control. Bioinformatics was used to predict the potential target gene of miR-378. Flow cytometry and Western blotting were performed to identify changes in the expression of CD226 protein. By co-culturing HUVECs with NK cells, the effects of miR-378 and CD226 on the proliferation, migration and apoptosis of HUVECs were evaluated. The results showed that the expression of miR-378 in peripheral blood was down-regulated with the progression of PIH. The expression of miR-378 was reduced in innate immune NK cells from peripheral blood of PIH patients. miR-378 negatively regulated the expression of CD226 in NK cells, and CD226 is a target gene of miR-378. miR-378 inhibited the expression and secretion of soluble CD226 by NK cells. miR-378 regulated the proliferation, migration and apoptosis of HUVECs by affecting the levels of soluble CD226 expressed by NK cells. The present study demonstrates that miR-378 is down-regulated in peripheral blood and NK cells from patients with PIH, and negatively correlated with the development of PIH. miR-378 protects HUVECs from injuries by soluble CD226 through down-regulating the expression of soluble CD226 in NK cells.

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Perinatal outcomes following labor induction with dinoprostone in pregnancies with borderline amniotic fluid index at term: A clinical observation study

Abstract: The perinatal outcomes of dinoprostone for induced labor are comparable between the two groups. Gestational hypertension and birth weight are factors related to outcomes of cesarean section in the borderline group.

Cited by 2 publications

References 32 publications

The Effect of Sildenafil Citrate on Improving Amniotic Fluid Index in Pregnant Women with Oligohydramnios and Borderline Oligohydramnios: A Randomized Controlled Trial

The Effect of Sildenafil Citrate on Improving Amniotic Fluid Index in Pregnant Women with Oligohydramnios and Borderline Oligohydramnios: A Randomized Controlled Trial

MicroRNA-378 protects human umbilical vein endothelial cells from injuries by soluble CD226 through down-regulating the expression of soluble CD226 in natural killer cells

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