Perinatal post-mortem ultrasound (PMUS): radiological-pathological correlation

Shelmerdine, Susan C.; Sebire, Neil J.; Arthurs, Owen J.

doi:10.1186/s13244-019-0762-2

Cited by 12 publications

(14 citation statements)

References 59 publications

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“…11,12 Accordingly, virtual and minimally invasive autopsies have emerged as complementary investigations to conventional autopsy owing to advancements in imaging technology and rapidly increasing demand. 9,10,13,14 Postmortem magnetic resonance imaging (pmMRI) has become a relevant virtual addition to conventional autopsy or is even considered an alternative, because it is less invasive and more readily accepted by the parents. 9,14,15 Previous small studies have evaluated the diagnostic value of pmMRI for fetal cardiac evaluation.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic quality of 3Tesla postmortem magnetic resonance imaging in fetuses with and without congenital heart disease

Ulm

Dovjak

Scharrer

et al. 2021

American Journal of Obstetrics and Gynecology

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Section: Introductionmentioning

confidence: 99%

Diagnostic quality of 3Tesla postmortem magnetic resonance imaging in fetuses with and without congenital heart disease

Ulm

Dovjak

Scharrer

et al. 2021

American Journal of Obstetrics and Gynecology

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“…PM‐US examinations were performed using a dedicated ultrasound machine based in the hospital mortuary (UGEO HM70A, Samsung, Munich, Germany, equipped with a 7–16‐MHz linear probe). The examinations were performed by a pediatric radiology research fellow (S.C.S., with 4 years' experience in postmortem pediatric imaging and 6 years' general pediatric radiology experience) according to previous publications 11 , 12 .…”

Section: Methodsmentioning

confidence: 99%

Diagnostic accuracy of postmortem ultrasound vs postmortem 1.5‐T MRI for non‐invasive perinatal autopsy

Shelmerdine

Sebire

Arthurs

2021

Ultrasound in Obstet & Gyne

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Objectives To determine the diagnostic accuracy of postmortem magnetic resonance imaging (PM‐MRI) and postmortem ultrasound (PM‐US) for perinatal autopsy in the same patient cohort, and to determine whether PM‐US can provide the same anatomical information as PM‐MRI. Methods In this prospective, 5‐year (July 2014–July 2019) single‐center study, we performed 1.5‐T PM‐MRI and PM‐US in an unselected cohort of perinatal deaths. The diagnostic accuracies of both modalities were calculated, using autopsy as the reference standard. As a secondary objective, the concordance rates between the two imaging modalities for the overall main diagnosis and for five anatomical regions (brain, spine, thorax, heart and abdomen) were calculated. Results During the study period, 136 cases underwent both PM‐US and PM‐MRI, of which 88 (64.7%) also underwent autopsy. There was no significant difference in the rates of concordance with autopsy between the two modalities for overall diagnosis (PM‐US, 86.4% (95% CI, 77.7–92.0%) vs PM‐MRI, 88.6% (95% CI, 80.3–93.7%)) or in the sensitivities and specificities for individual anatomical regions. There were more non‐diagnostic PM‐US than PM‐MRI examinations for the brain (22.8% vs 3.7%) and heart (14.7% vs 5.1%). If an ‘imaging‐only’ autopsy had been performed, PM‐US would have achieved the same diagnosis as 1.5‐T PM‐MRI in 86.8% (95% CI, 80.0–91.5%) of cases, with the highest rates of agreement being for spine (99.3% (95% CI, 95.9–99.9%)) and cardiac (97.3% (95% CI, 92.4–99.1%)) findings and the lowest being for brain diagnoses (85.2% (95% CI, 76.9–90.8%)). Conclusion Although there were fewer non‐diagnostic cases using PM‐MRI than for PM‐US, the high concordance rate for overall diagnosis suggests that PM‐US could be used for triaging cases when PM‐MRI access is limited or unavailable. © 2020 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.

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“…The ESPR and the International Society for Forensic Radiology and Imaging (ISFRI) have published recommendations for paediatric post-mortem CT imaging [ 41 ]; however, these are typically applied to forensic childhood cases rather than perinatal deaths. Where post-mortem ultrasound is performed, two articles in Insights into Imaging describe how to conduct, report and recognise common developmental pathologies [ 42 ].…”

Section: Published Protocols For Paediatric and Perinatal Post-mortem Imaging Techniquesmentioning

confidence: 99%

A pragmatic evidence-based approach to post-mortem perinatal imaging

et al. 2021

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Post-mortem imaging has a high acceptance rate amongst parents and healthcare professionals as a non-invasive method for investigating perinatal deaths. Previously viewed as a ‘niche’ subspecialty, it is becoming increasingly requested, with general radiologists now more frequently asked to oversee and advise on appropriate imaging protocols. Much of the current literature to date has focussed on diagnostic accuracy and clinical experiences of individual centres and their imaging techniques (e.g. post-mortem CT, MRI, ultrasound and micro-CT), and pragmatic, evidence-based guidance for how to approach such referrals in real-world practice is lacking. In this review, we summarise the latest research and provide an approach and flowchart to aid decision-making for perinatal post-mortem imaging. We highlight key aspects of the maternal and antenatal history that radiologists should consider when protocolling studies (e.g. antenatal imaging findings and history), and emphasise important factors that could impact the diagnostic quality of post-mortem imaging examinations (e.g. post-mortem weight and time interval). Considerations regarding when ancillary post-mortem image-guided biopsy tests are beneficial are also addressed, and we provide key references for imaging protocols for a variety of cross-sectional imaging modalities.

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Perinatal post-mortem ultrasound (PMUS): radiological-pathological correlation

Cited by 12 publications

References 59 publications

Diagnostic quality of 3Tesla postmortem magnetic resonance imaging in fetuses with and without congenital heart disease

Diagnostic quality of 3Tesla postmortem magnetic resonance imaging in fetuses with and without congenital heart disease

Diagnostic accuracy of postmortem ultrasound vs postmortem 1.5‐T MRI for non‐invasive perinatal autopsy

A pragmatic evidence-based approach to post-mortem perinatal imaging

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