Perinatal Taurine Supplementation Prevents the Adverse Effects of Maternal Dyslipidemia on Growth and Cardiovascular Control in Adult Rat Offspring

Thaeomor, Atcharaporn; Tangnoi, Chonticha; Seanthaweesuk, Suphaket; Somparn, Nuntiya; Roysommuti, Sanya

doi:10.1007/978-981-13-8023-5_39

Cited by 4 publications

(5 citation statements)

References 26 publications

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“…Reprogramming effects have been observed through amino-acid-targeted therapies in rats ranging from 4 weeks to 50 weeks old, coarsely equivalent to human ages spanning from young children to middle adulthood [139]. Amino acid supplementation utilized as reprogramming interventions includes arginine [116], citrulline [62,[117][118][119][120][121], taurine [122][123][124][125][126][127][128][129], cysteine [130][131][132][133][134], glycine [135], BCAAs [136,137], and tryptophan [138]. The subsequent sections will delve into each of these aspects in detail.…”

Section: Effects Of Perinatal Amino Acid Supplementation On Offspring...mentioning

confidence: 99%

“…As the most prevalent sulfur-containing amino acid [152], taurine is predominantly acquired through dietary sources, although its synthesis is also possible from cysteine. The table illustrates that maternal taurine supplementation provides protection against hypertension programmed by maternal high-sugar intake [124], maternal CKD [125], STZ-induced diabetes [126], or maternal dyslipidemia [127]. Furthermore, perinatal taurine supplementation has demonstrated efficacy in preventing hypertension in SHRs and stroke-prone spontaneously hypertensive rats (SHRSP) [128,129].…”

Section: Taurinementioning

confidence: 99%

“…Furthermore, perinatal taurine supplementation has demonstrated efficacy in preventing hypertension in SHRs and stroke-prone spontaneously hypertensive rats (SHRSP) [128,129]. In addition, maternal taurine supplementation can ameliorate obesity programmed by a maternal high-fat/high-fructose diet [122] and maternal dyslipidemia [127]. Using a NOD mice model, perinatal taurine treatment was shown to delay the onset time of diabetes from 18 to 30 weeks in female offspring, and from 30 to 38 weeks in male offspring [123].…”

Section: Taurinementioning

confidence: 99%

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Amino Acids during Pregnancy and Offspring Cardiovascular–Kidney–Metabolic Health

Tain,

Hsu

2024

Nutrients

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Amino acids are essential for normal pregnancy and fetal development. Disruptions in maternal amino acid metabolism have been associated with various adult diseases later in life, a phenomenon referred to as the developmental origins of health and disease (DOHaD). In this review, we examine the recent evidence highlighting the significant impact of amino acids on fetal programming, their influence on the modulation of gut microbiota, and their repercussions on offspring outcomes, particularly in the context of cardiovascular–kidney–metabolic (CKM) syndrome. Furthermore, we delve into experimental studies that have unveiled the protective effects of therapies targeting amino acids. These interventions have demonstrated the potential to reprogram traits associated with CKM in offspring. The discussion encompasses the challenges of translating the findings from animal studies to clinical applications, emphasizing the complexity of this process. Additionally, we propose potential solutions to overcome these challenges. Ultimately, as we move forward, future research endeavors should aim to pinpoint the most effective amino-acid-targeted therapies, determining the optimal dosage and mode of administration. This exploration is essential for maximizing the reprogramming effects, ultimately contributing to the enhancement of cardiovascular–kidney–metabolic health in offspring.

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Section: Effects Of Perinatal Amino Acid Supplementation On Offspring...mentioning

confidence: 99%

Section: Taurinementioning

confidence: 99%

Section: Taurinementioning

confidence: 99%

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Amino Acids during Pregnancy and Offspring Cardiovascular–Kidney–Metabolic Health

Tain,

Hsu

2024

Nutrients

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“…Several animal studies have also reported beneficial effects of maternal dietary interventions. For example, maternal taurine supplementation during the perinatal period lowers the risk of cardiovascular diseases in the offspring after birth 141 . Supplementation with betaine, phytosterol, choline, α‐ketoglutaric acid, or antioxidants during pregnancy improves fetal liver lipid accumulation 94,142–145 .…”

Section: Prevention and Treatment Of Fetal‐originated Hypercholestero...mentioning

confidence: 99%

“…For example, maternal taurine supplementation during the perinatal period lowers the risk of cardiovascular diseases in the offspring after birth. 141 Supplementation with betaine, phytosterol, choline, α-ketoglutaric acid, or antioxidants during pregnancy improves fetal liver lipid accumulation. 94,[142][143][144][145] Moreover, for mothers with T A B L E 2 Adverse intrauterine environment-induced epigenetic modifications of genes related to hepatic cholesterol metabolism in fetuses.…”

Section: Prevention and Treatment Of Fetal-originated Hypercholestero...mentioning

confidence: 99%

Intrauterine developmental origin, programming mechanism, and prevention strategy of fetal‐originated hypercholesterolemia

Liu,

Chen,

et al. 2023

Obesity Reviews

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SummaryThere is increasing evidence that hypercholesterolemia has an intrauterine developmental origin. However, the pathogenesis of fetal‐originated is still lacking in a theoretical system, which makes its clinical early prevention and treatment difficult. It has been found that an adverse environment during pregnancy (e.g., xenobiotic exposure) may lead to changes in fetal blood cholesterol levels through changing maternal cholesterol metabolic function and/or placental cholesterol transport function and may also directly affect the liver cholesterol metabolic function of the offspring in utero and continue after birth. Adverse environmental conditions during pregnancy may also raise maternal glucocorticoid levels and promote the placental glucocorticoid barrier opening, leading to fetal overexposure to maternal glucocorticoids. Intrauterine high‐glucocorticoid exposure can alter the liver cholesterol metabolism of offspring, resulting in an increased susceptibility to hypercholesterolemia after birth. Abnormal epigenetic modifications are involved in the intrauterine programming mechanism of fetal‐originated hypercholesterolemia. Some interventions targeted at pregnant mothers or offspring in early life have been proposed to effectively prevent and treat the development of fetal‐originated hypercholesterolemia. In this paper, the recent research progress on fetal‐originated hypercholesterolemia was reviewed, with emphasis on intrauterine maternal glucocorticoid programming mechanisms, in order to provide a theoretical basis for its early clinical warning, prevention, and treatment.

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Perinatal Taurine Supplementation Preserves the Benefits of Dynamic Exercise Training on Cardiovascular and Metabolic Functions and Prevents Organ Damage in Adult Male Exercised Rats

Thaeomor

Tangnoi

Teangphuck

et al. 2022

Advances in Experimental Medicine and Biology

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Perinatal Taurine Supplementation Prevents the Adverse Effects of Maternal Dyslipidemia on Growth and Cardiovascular Control in Adult Rat Offspring

Cited by 4 publications

References 26 publications

Amino Acids during Pregnancy and Offspring Cardiovascular–Kidney–Metabolic Health

Amino Acids during Pregnancy and Offspring Cardiovascular–Kidney–Metabolic Health

Intrauterine developmental origin, programming mechanism, and prevention strategy of fetal‐originated hypercholesterolemia

Perinatal Taurine Supplementation Preserves the Benefits of Dynamic Exercise Training on Cardiovascular and Metabolic Functions and Prevents Organ Damage in Adult Male Exercised Rats

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