Perinatal Toxicity Associated with Nickel Chloride Exposure

Smith, Milton T.; George, Emma Lou; Stober, Judy A.; Feng, Haibo; Kimmel, Gary L.

doi:10.1006/enrs.1993.1064

Cited by 39 publications

(53 citation statements)

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“…Mitigating toxicity concerns is especially important for Ni released in the body. There have been many studies investigating the non-cancer toxicity of nickel through various routes of exposure [20][21][22][23]. However, for implantable nickel-based devices, there have been no definitive tolerable intake values reported.…”

Section: Discussionmentioning

confidence: 99%

Effects of Oxide Layer Composition and Radial Compression on Nickel Release in Nitinol Stents

Sullivan

Dreher

Zheng

et al. 2015

Shap. Mem. Superelasticity

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There is a public health need to understand the effects of surface layer thickness and composition on corrosion in nickel-containing medical devices. To address this knowledge gap, five groups of Nitinol stents were manufactured by various processing methods that altered the titanium oxide layer. The following surfaces were created: [3500 nm thick mixed thermal oxide (OT), *420 nm thick mixed thermal oxide (SP), *130 nm thick mixed thermal oxide (AF), *4 nm thick native oxide (MP), and an *4 nm thick passivated oxide (EP). Radially compressed and not compressed devices were evaluated for nickel (Ni) ion release in a 60-day immersion test. The results indicated that OT stents released the most Ni, followed by stents in the SP and AF groups. For OT and SP stents, which exhibited the thickest oxide layers, radial compression significantly increased Ni release when compared to non-compressed stents. This result was not observed in AF, MP, SP stents indicating that the increased Ni release may be explained by cracking of the thicker oxide layers during crimping. Strong correlations were observed between oxide layer thickness and cumulative Ni release. These findings elucidate the importance of oxide layer thickness and composition on uniform corrosion of laser-cut Nitinol stents.

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Section: Discussionmentioning

confidence: 99%

Effects of Oxide Layer Composition and Radial Compression on Nickel Release in Nitinol Stents

Sullivan

Dreher

Zheng

et al. 2015

Shap. Mem. Superelasticity

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“…as Ni sulfate hexahydrate per day for 10 weeks prior to mating, during mating, gestation, and lactation (SLI, 2000b), or in a 2-litter study in which female rats were exposed to doses as high as 31.6 mg Ni/kg b.w. per day (Smith et al, 1993). Toman et al (2012) demonstrated the adverse effect of Ni on the mouse testis structure from three to 12 weeks of administration in feed of 10 mg NiCl 2 /kg b.w.…”

Section: Developmental and Reproductive Toxicitymentioning

confidence: 96%

“…The TI for Ni sulfate is based on the Ambrose et al (1976) study by applying an UF of 100. The TI for Ni chloride is based on the reproductive toxicity study by Smith et al (1993). In this study female rats drank Ni chloride solutions for 11 weeks prior to mating and then during two successive gestation and lactation periods.…”

Section: Previous Risk Assessmentsmentioning

confidence: 99%

“…Table 19: Results of the BMD analysis of the dose-response data on reproductive and developmental effects of nickel sulfate hexahydrate in rats observed for the F1 generation in the dose range finding (DRF), the two-generation study Two other studies on reproductive and developmental toxicity were identified which reported doseresponse data suitable for a BMD analysis (Smith et al, 1993;Panday and Srivastava, 2000). The study on reproductive toxicity of Panday and Srivastava (2000) reported a dose response relationship for the percentage of motile sperms in epididymis (in units of 10 -7…”

Section: Effects In Experimental Animalsmentioning

confidence: 99%

“…per day for percentage of motile sperms and sperm count in epididymis, respectively -see Appendix G. No complete BMD analysis was possible for percentage of abnormal sperms since explicit data on the variability of the estimates were missing. Smith et al (1993) studied reproductive and developmental toxicity in female Long-Evans rats treated with Ni chloride in two breedings -see Section 7.2.3. Whereas the numbers of alive and dead pups showed no dose-response relationship a dose dependent trend was observed for the number of litters with dead pups at birth and the mean values and the percentage of dead pups at PND1 and PND21.…”

Section: Effects In Experimental Animalsmentioning

confidence: 99%

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Scientific Opinion on the risks to public health related to the presence of nickel in food and drinking water

Publication¹

2015

EFS2

119

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EFSA received a request from the Hellenic Food Authority (EFET) for a scientific opinion on the risk to human health from the presence of nickel (Ni) in food, particularly in vegetables. The EFSA Panel on Contaminants in the Food Chain (CONTAM Panel) decided to extend the risk assessment also to drinking water. The reproductive and developmental toxicity in experimental animals was selected as the critical effect for the assessment of chronic effects of Ni. A tolerable daily intake of 2.8 µg Ni/kg body weight (b.w.) per day was derived from a lower 95 % confidence limit for a benchmark dose at 10 % extra risk (BMDL 10 ) of 0.28 mg/kg b.w. for post-implantation fetal loss in rats. The current dietary exposure to Ni raises concern when considering the mean and 95th percentile chronic exposure levels for all different age groups. The systemic contact dermatitis (SCD) elicited in Ni-sensitive humans after oral exposure to Ni was selected as the critical effect suitable for the assessment of acute effects of Ni. A lowest BMDL 10 of 1.1 µg Ni/kg b.w. was derived for the incidence of SCD following oral exposure to Ni of human volunteers. The CONTAM Panel applied a margin of exposure (MOE) approach and considered an MOE of 10 to be indicative of a low health concern. The MOEs calculated considering the estimated mean and the 95th percentile acute exposure levels were considerably below 10 for all age groups. Overall, the CONTAM Panel concluded that, at the current levels of acute dietary exposure to Ni, there is a concern that Ni-sensitized individuals may develop eczematous flare-up skin reactions. The CONTAM Panel noted the need for mechanistic studies to assess the human relevance of the effects on reproduction and development observed in experimental animals and for additional studies on human absorption of nickel from food, for example in combination with duplicate diet studies. Following a call for data on Ni levels in food and drinking water (water intended for human consumption and mineral waters), a total of 18 885 food samples and 25 700 drinking water samples were available in the final dataset to estimate dietary exposure to nickel. No speciation data were provided. Samples were collected between 2003 and 2012 in 15 different European countries, with almost 80 % of the total collected in one Member State. The most reported analytical methods were inductively coupled plasma-mass spectrometry (ICP-MS) and atomic absorption spectrometry (AAS), that represented 54 % and 42 % of the methods reported, respectively. The highest sensitivity was reported for the analysis of drinking water with a limit of quantification (LOQ) of 0.001 µg/L (for both ICP-MS and AAS). In food, ICP-MS showed the lowest LOQ for the analysis of 'Alcoholic beverages' (0.002 µg/kg) while the lowest LOQ reported with AAS was 1 µg/kg for samples of 'Fish and seafood' and 'Sugar and confectionery'. In the final dataset, left-censored data represented 66 % of the analytical results, with 35 % in food samples and 89 % in drinking water sa...

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Nickel and Its Compounds

Buxton,

Verpaele,

Oller

2023

Patty's Toxicology

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Nickel (Ni) is a naturally occurring element in the transition metals of the periodic table. Nickel is naturally present in the Earth's crust, rocks, soil, plants, and water; nickel is essential to some microorganisms and plants. Thus, nickel is naturally found in a variety of crops, foodstuffs, and animals. Nickel and its compounds are used extensively in applications like batteries, stainless steel, and medical devices. Thus, natural and anthropogenic exposures to nickel and its compounds are ubiquitous. The human toxicities associated with excess exposure to nickel include nickel allergic contact dermatitis, respiratory cancer, noncancer respiratory toxicity, and reproductive effects. The bioavailable nickel +2 ion is reported to drive the toxicities associated with nickel. In this book chapter on nickel and its compounds, we explore the physical and chemical properties, production and use, occupational and nonoccupational exposures, toxicokinetics, toxicities, workplace exposure assessment and surveillance, and last but not least, environmental exposure assessment and surveillance of nickel and nickel compounds.

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Perinatal Toxicity Associated with Nickel Chloride Exposure

Cited by 39 publications

References 0 publications

Effects of Oxide Layer Composition and Radial Compression on Nickel Release in Nitinol Stents

Effects of Oxide Layer Composition and Radial Compression on Nickel Release in Nitinol Stents

Scientific Opinion on the risks to public health related to the presence of nickel in food and drinking water

Nickel and Its Compounds

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