Perinatal Transmission of Human Papillomavirus From Gravidas With Latent Infections

Implications of Human Papillomavirus Infections in the Biology of Head and Neck Cancers

“…Other studies also suggest that vertical transmission is common, occurring in 40% to 80% of cases (Puranen et al, 1996;Rintala et al, 2005b;Tseng et al, 1998). These high rates of vertical HPV transmission were not confirmed by several studies, which found that the risk of vertical transmission to the oral or genital mucosa of newborns was rare (1-5%) (Smith et al, 1995(Smith et al, , 2004b(Smith et al, , 2010Syrjänen & Puranen, 2000Tenti et al, 1999Watts et al, 1998). In two previous studies by Smith et al, only one mother/newborn pair was concordant for an HPV type, and among 203 infants, two had detectable HPV in oral or genital swabs (Smith et al, 1995(Smith et al, , 2004b.…”

“…According to the age studied, there are variations in the prevalence rate. In nasopharyngeal aspirates collected immediately after birth, the detection rate of HPV varies from 1.5% to 37% (Cason et al, 1995;Castellsague et al, 2009;Mazzatenta et al, 1996;Puranen et al, 1996Puranen et al, , 1997Rintala et al, 2005aRintala et al, , 2005bRombaldi et al, 2008;Sedlacek et al, 1989;Tenti et al, 1997Tenti et al, , 1999Watts et al, 1998). At the age of 1-4 days, Smith et al in two studies found a low HPV incidence (from 0.9% to 1%) in the buccal swabs of neonates, whereas other studies showed a higher prevalence varying from 40% to 56% (Cason et al, 1995;Kaye et al, 1994;Pakarian et al, 1994;Tseng et al, 1998;Smith et al, 1995Smith et al, , 2004b.…”

Human Papillomavirus and Related Diseases - From Bench to Bedside - A Clinical Perspective

“…Other studies also suggest that vertical transmission is common, occurring in 40% to 80% of cases (Puranen et al, 1996;Rintala et al, 2005b;Tseng et al, 1998). These high rates of vertical HPV transmission were not confirmed by several studies, which found that the risk of vertical transmission to the oral or genital mucosa of newborns was rare (1-5%) (Smith et al, 1995(Smith et al, , 2004bSyrjänen & Puranen, 2000Tenti et al, 1999Watts et al, 1998). In two previous studies by Smith et al, only one mother/newborn pair was concordant for an HPV type, and among 203 infants, two had detectable HPV in oral or genital swabs (Smith et al, 1995(Smith et al, , 2004b.…”

“…According to the age studied, there are variations in the prevalence rate. In nasopharyngeal aspirates collected immediately after birth, the detection rate of HPV varies from 1.5% to 37% (Cason et al, 1995;Castellsague et al, 2009;Mazzatenta et al, 1996;Puranen et al, 1996Puranen et al, , 1997Rintala et al, 2005aRintala et al, , 2005bRombaldi et al, 2008;Sedlacek et al, 1989;Tenti et al, 1997Tenti et al, , 1999Watts et al, 1998). At the age of 1-4 days, Smith et al in two studies found a low HPV incidence (from 0.9% to 1%) in the buccal swabs of neonates, whereas other studies showed a higher prevalence varying from 40% to 56% (Cason et al, 1995;Kaye et al, 1994;Pakarian et al, 1994;Tseng et al, 1998;Smith et al, 1995Smith et al, , 2004b.…”

Epidemiology of Mucosal Human Papillomavirus (HPV) Infections Among Adult and Children

“…A systematic review (Medeiros et al, 2005) reported a higher risk of HPV infection after vaginal delivery than after cesarean section (RR: 1.8; 95%CI: 1.3-2.4). The risk of transmission has also www.intechopen.com been identified as increasing with the rupture of membranes; the longer time rupture of membranes occurred before delivery, higher risk of transmission (Tenti et al, 1999 Only a few studies have analysed the probability of persistence among babies born to HPVinfected mothers such as Rombaldi et al (2009) and Watts et al (1998) who have reported a very low proportion of persistent infection in infants (reported 0% in a 1 and 3-year followup study, respectively) whereas some reported very high proportions ranging from 27 to 56% (Fredericks et al, 1993;Kaye et al, 1994;Pakarian et al, 1994;Cason et al, 1995Cason et al, , 2005Syrjänen et al, 2000). These studies have shown that perinatally acquired HPV can persist for at least 2 years and that HPV is mostly prevalent during the first year of infancy reaching a peak at 6 months of age.…”