Perinatal Vertical Transmission of Human Papillomavirus and Subsequent Development of Respiratory Tract Papillomatosis

Smith, Elaine; Johnson, Susan R.; Pignatari, Shirley Shizue Nagata; Cripe, Timothy P.; Turek, Lubomír P.

doi:10.1177/000348949110000610

Cited by 97 publications

(46 citation statements)

References 14 publications

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“…The HPV positivity rate in oral specimens collected from 68 current male partners who visited the clinic with the pregnant women was 5.9% (4). None of the infected men had female partners who concurrently were infected in either the oral or genital areas; thus there also was no viral concordance between partners.…”

Section: Oral-hpv Resultsmentioning

confidence: 98%

“…HPV infection also may be transmitted vertically during parturition [4][5][6] . This proposition is of concern since the prevalence of detectable maternal HPV infection during pregnancy reportedly may rise during the second and third trimester above that of non-pregnant women, thus increasing the probability of HPV exposure to perinatal transmission at the time of delivery 5,7 .…”

mentioning

confidence: 99%

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HPV Prevalence and Concordance in the Cervix and Oral Cavity of Pregnant Women

Smith

Ritchie

Yankowitz

et al. 2003

Infectious Diseases in Obstetrics and Gynecology

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Objectives: This investigation examined human papillomavirus (HPV) in pregnant women in order to characterize viral prevalence, types and concordance between infection in the cervix and in the oral cavity. Methods: A total of 577 pregnant women seeking routine obstetric care were evaluated for HPV infection in their cervix during gestation and immediately before delivery, and in the oral cavity during gestation. Male partners present during the gestational clinic visit also provided a specimen from their oral cavity. HPV assessment was performed by PCR, dot blot hybridization and DNA sequencing. A sexual and health questionnaire was completed by the pregnant women. Results: HPV prevalence in women was 29% in the cervix and 2.4% in the oral cavity. Among those with both gestational and delivery specimens, 35% were infected at least once and 20% had infection at both intervals. At delivery, 68% of infected women had an oncogenic HPV type in the cervix. There was no type-specific HPV concordance between the two cervical specimens, nor cervical and oral results in women, nor with cervical and oral findings between partners. Conclusion: The lack of association in HPV positivity and types between the cervix and oral cavity in these women suggests that self-inoculation is uncommon. This source of infection does not appear to be from oral contact with a current male partner, since there also was no concordance between partners. These results suggest either other modes of HPV transmission or differences in susceptibility to HPV infection or its clearance in the oral cavity and genital mucosa.

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Section: Oral-hpv Resultsmentioning

confidence: 98%

mentioning

confidence: 99%

HPV Prevalence and Concordance in the Cervix and Oral Cavity of Pregnant Women

Smith

Ritchie

Yankowitz

et al. 2003

Infectious Diseases in Obstetrics and Gynecology

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“…HPV is positive in the airways of neonates and in maternal genital condylomas, which suggests that it is transmitted in the birth canal, from mothers with genital condylomas. 27 Since the serologic diagnosis of HPV is inadequate, molecular diagnosis has been more popular in recent years. 28 Epidemiological studies revealed different results in pregnant women.…”

Section: Discussionmentioning

confidence: 99%

Molecular detection of cytomegalovirus, herpes simplex virus 2, human papillomavirus 16-18 in Turkish pregnants

Dinç¹,

Bozdayı²,

Bırı³

et al. 2010

Braz J Infect Dis

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Objective: Human cytomegalovirus (CMV) is the most common cause of viral intrauterine infections in the world. Herpes simplex virus type 2 (HSV-2) and human papillomavirus (HPV) are the main agents of viral sexually transmitted diseases, which cause genital ulcers and genital warts, respectively. HPV infection has been linked to the majority of the anogenital malignancies. The aim of this study was to detect the existence of CMV, HSV-2 and HPV type 16-18 in Turkish pregnants by using sensitive molecular assays. Methods: One hundred thirty-four women (18-41 years old; mean age ± SD: 27 ± 8) applied to outpatient clinic of Obstetrics and Gynecology, in between 18th -22nd weeks of their pregnancy and a control group of 99 healthy women (15-39 years old; mean age ± SD: 24 ± 8) were included in the study. Cervical smear samples were used for DNA extraction. CMV, HSV-2 and HPV 16-18 detections were carried out by real time PCR and in house PCR method, respectively. Results: Three patients (3/134; 2.2%) were found to be positive for each HPV and HSV-2. Dual infection with HPV and HSV was found in just one patient. HPV 18 was detected in all positive samples. CMV was found to be positive in two patients (2/134; 1.4 %). Conclusion: HPV, HSV and CMV must be screened due to high prevalence of these viruses in pregnants by using sensitive molecular methods.

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“…HPV is positive in the airways of neonates and in maternal genital condylomas, which suggests that it is transmitted in the birth canal, from mothers with genital condylomas. 12 Occasionally, however, HPV is positive in newborns of mother with no history of genital condylomas, suggesting the possibility of latent or subclinical products, which may explain recurrences after a long time period of disease remission. 13 Some studies have found HPV in benign laryngeal lesions such as polyps, Reinke's edema, leukoplasia, lichen planus, and even in the normal mucosa of the mouth.…”

Section: Introductionmentioning

confidence: 99%

Papilomatose laríngea: análise morfológica pela microscopia de luz e eletrônica do HPV-6

Martins

Dias

Gregório

et al. 2008

Rev. Bras. Otorrinolaringol.

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Laryngeal papillomatosis is the most frequent benign neoplasia in children. It is caused by HPV 6 and 11. The lesions are exophytic and highly recurrent, compromising the airway mucosa, mainly the larynx. Study design -clinical prospective. Aims: to show morphologic alterations of the epithelium (light and electron microscopy) in the HPV-6 lesions. Methods: specimens of laryngeal lesions obtained during surgery of four children (1 male, 3 female) were submitted to HPV typing (PCR), light microscopy and electron microscopy. Results: in all specimens, HPV type 6 was found. Epithelial projections were found by electron microscopy with superficial cells in desquamation. Light microscopy showed exophytic projections of the keratinized stratified squamous epithelium overlying a fibrovascular core. Koilocytes (vacuolated cells), suggesting the viral infection by HPV, were identified. No alterations were seen in the basement membrane and corion. Ultraestrutural analysis showed vacuolated cells with clear cytoplasmic inclusions, intercellular injuries and widening intercellular spaces. Conclusions: morphologic alterations of the epithelium in the HPV-6 lesions are superficial, and additional studies including the others HPV types are needed to show the more aggressive and extensive aspect of the disease.

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Perinatal Vertical Transmission of Human Papillomavirus and Subsequent Development of Respiratory Tract Papillomatosis

Cited by 97 publications

References 14 publications

HPV Prevalence and Concordance in the Cervix and Oral Cavity of Pregnant Women

HPV Prevalence and Concordance in the Cervix and Oral Cavity of Pregnant Women

Molecular detection of cytomegalovirus, herpes simplex virus 2, human papillomavirus 16-18 in Turkish pregnants

Papilomatose laríngea: análise morfológica pela microscopia de luz e eletrônica do HPV-6

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