PerinatalUreaplasma Urealyticum infection increases the need for hospital treatment during the first year of life in preterm infants

Ollikainen, Jukka

doi:10.1002/1099-0496(200011)30:5<402::aid-ppul6>3.0.co;2-j

Cited by 10 publications

(1 citation statement)

References 11 publications

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“…This problem is confounded by the fact that most neonates with clinically significant respiratory, bloodstream, and/or cerebrospinal fluid infection with these organisms are born preterm and are therefore at much higher risk for long-term sequelae unrelated to the presence of these microorganisms. Ollikainen et al (203) determined that 22 infants from whom Ureaplasma spp. were detected in blood experienced significantly more hospital stays and remained hospitalized for more days during the first 12 months of postnatal life than 18 infants without infection (546 FIG.…”

Section: Pneumonia and Other Respiratory Diseases In Older Infants Anmentioning

confidence: 99%

Mycoplasmas and Ureaplasmas as Neonatal Pathogens

Katz²,

2005

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SUMMARY The genital mycoplasmas represent a complex and unique group of microorganisms that have been associated with a wide array of infectious diseases in adults and infants. The lack of conclusive knowledge regarding the pathogenic potential of Mycoplasma and Ureaplasma spp. in many conditions is due to a general unfamiliarity of physicians and microbiology laboratories with their fastidious growth requirements, leading to difficulty in their detection; their high prevalence in healthy persons; the poor design of research studies attempting to base association with disease on the mere presence of the organisms in the lower urogenital tract; the failure to consider multifactorial aspects of diseases; and considering these genital mycoplasmas only as a last resort. The situation is now changing because of a greater appreciation of the genital mycoplasmas as perinatal pathogens and improvements in laboratory detection, particularly with regard to the development of powerful molecular nucleic acid amplification tests. This review summarizes the epidemiology of genital mycoplasmas as causes of neonatal infections and premature birth; evidence linking ureaplasmas with bronchopulmonary dysplasia; recent changes in the taxonomy of the genus Ureaplasma; the neonatal host response to mycoplasma and ureaplasma infections; advances in laboratory detection, including molecular methods; and therapeutic considerations for treatment of systemic diseases.

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Section: Pneumonia and Other Respiratory Diseases In Older Infants Anmentioning

confidence: 99%