Perindopril increases the swallowing reflex by inhibiting substance P degradation and tyrosine hydroxylase activation in a rat model of dysphagia

Ikeda, Junichi; Kojima, Natsuki; Saeki, Kazutoshi; Ishihara, Miki; Takayama, Makoto

doi:10.1016/j.ejphar.2014.11.002

Cited by 16 publications

(14 citation statements)

References 35 publications

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“…In agreement with previous studies [8,33], we confirmed that 2VO prolonged the onset latency to the first swallowing and decreased the numbers of swallows evoked by the stimulation solutions. Zhang et al [8] revealed that the same rat model has a significant bacterial infection of the lungs two weeks after 2VO, suggesting that this animal model meets the research on cerebral ischemia-related oropharyngeal dysphagia.…”

Section: Discussionsupporting

confidence: 93%

“…These findings support a significant role of the dopamine-SP system in regulating the swallowing reflex. The 2VO model reproduces impairment of swallowing reflex in a manner similar to that observed in post-stroke patients with dysfunction of the nigrostriatal dopamine-SP system [8,33]. We confirmed that the expression levels of TH, a rate-limiting enzyme for the synthesis of catechol amines including dopamine, significantly decreased in the striatum at 14 days post-2VO, which was concurrent with a decrease in dopamine content of the region.…”

Section: Discussionsupporting

confidence: 82%

“…Cerebral hypoperfusion was induced by 2VO in rats, as previously described [8,33]. Rats were anesthetized using isoflurane, with 5% for induction and 2% for maintenance.…”

Section: Methodsmentioning

confidence: 99%

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Protective Effects of Ferulic Acid against Chronic Cerebral Hypoperfusion-Induced Swallowing Dysfunction in Rats

Asano

Matsuzaki

Iwata

et al. 2017

IJMS

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Ferulic acid (FA), a phenolic phytochemical, has been reported to exert antioxidative and neuroprotective effects. In this study, we investigated the protective effects of FA against the dysfunction of the swallowing reflex induced by ligation of bilateral common carotid arteries (2VO) in rats. In 2VO rats, topical administration of water or citric acid to the pharyngolaryngeal region evoked a diminished number of swallowing events with prolonged latency compared to sham-operated control rats. 2VO rats had an increased level of superoxide anion radical, and decreased dopamine and tyrosine hydroxylase enzyme levels in the striatum, suggesting that 2VO augmented cerebral oxidative stress and impaired the striatal dopaminergic system. Furthermore, substance P (SP) expression in the laryngopharyngeal mucosa, which is believed to be positively regulated by dopaminergic signaling in the basal ganglia, was decreased in 2VO rats. Oral treatment with FA (30 mg/kg) for 3 weeks (from one week before 2VO to two weeks after) improved the swallowing reflex and maintained levels of striatal dopamine and laryngopharyngeal SP expression in 2VO rats. These results suggest that FA maintains the swallowing reflex by protecting the dopamine-SP system against ischemia-induced oxidative damage in 2VO rats.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 82%

See 1 more Smart Citation

Protective Effects of Ferulic Acid against Chronic Cerebral Hypoperfusion-Induced Swallowing Dysfunction in Rats

Asano

Matsuzaki

Iwata

et al. 2017

IJMS

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“…The increase of the afterload may be induced by the release of noradrenaline from the peripheral nerve terminals into the vessels (Lechin et al, 2010), and this vasopressor effect was consistent with previous in vivo study of rats (Ikeda et al, 2015). Meanwhile, the cardiac output decreased, but the preload to the ventricle increased, which may suggest that extent of increase in the afterload was greater than that of the ventricular contraction.…”

Section: Cardiohemodynamic Effectssupporting

confidence: 77%

Electropharmacological effects of amantadine on cardiovascular system assessed with J-Tpeak and Tpeak-Tend analysis in the halothane-anesthetized beagle dogs

et al. 2016

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-Since amantadine-induced long QT syndrome has been clinically reported, we investigated its electropharmacological effects to estimate the extent of proarrhythmic risk by using the halothane-anesthetized beagle dogs (n = 4). Amantadine in doses of 0.1, 1 and 10 mg/kg was infused over 10 min with a pause of 20 min under the monitoring of multiple cardiovascular variables. J-T peak and T peak -T end were separately measured on the lead II electrocardiogram to precisely analyze the net balance between inward and outward current modifications by amantadine. The low dose increased the ventricular contractile force, but suppressed the intraventricular conduction. The middle dose prolonged the QT interval besides enhancing the changes induced by the low dose. The high dose increased the mean blood pressure, left ventricular end-diastolic pressure and total peripheral resistance, and accelerated the atrioventricular nodal conduction, but decreased the cardiac output besides enhancing the changes induced by the middle dose. A reverse use-dependence was confirmed in the repolarization delay. Amantadine hardly affected the J-T peak , but prolonged the T peak -T end . Amantadine can be considered to stimulate Ca 2+ channel but inhibit Na + and K + channels in the in situ heart. J-T peak and T peak -T end analysis suggests that amantadine may possess modest risk for arrhythmia.

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“…ACE inhibitors Table 2 Potential causative microbiological pathogens in elderly patients with various types of pneumonia. Type of pneumonia and cilostazol are thought to increase substance P levels in the airways and plasma, improving both swallowing and cough reflexes in the elderly [54,55]. In a 2-year follow-up study of stroke patients, pneumonia-associated mortality was significantly lower in older hypertensive patients administered with ACE inhibitors than in those treated with other antihypertensive drugs [50].…”

Section: Pharmacologic Approaches For Dysphagia and Upper Airway Manamentioning

confidence: 98%

Update on the pathogenesis and management of pneumonia in the elderly-roles of aspiration pneumonia

Teramoto

Yoshida

Hizawa

2015

Respiratory Investigation

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Perindopril increases the swallowing reflex by inhibiting substance P degradation and tyrosine hydroxylase activation in a rat model of dysphagia

Cited by 16 publications

References 35 publications

Protective Effects of Ferulic Acid against Chronic Cerebral Hypoperfusion-Induced Swallowing Dysfunction in Rats

Protective Effects of Ferulic Acid against Chronic Cerebral Hypoperfusion-Induced Swallowing Dysfunction in Rats

Electropharmacological effects of amantadine on cardiovascular system assessed with J-T<sub>peak</sub> and T<sub>peak</sub>-T<sub>end</sub> analysis in the halothane-anesthetized beagle dogs

Update on the pathogenesis and management of pneumonia in the elderly-roles of aspiration pneumonia

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