Perindopril Induces TSP-1 Expression in Hypertensive Patients with Endothelial Dysfunction in Chronic Treatment

Abstract

Thrombospondin-1 (TSP-1) is a potent endogenous inhibitor of both physiological and pathological angiogenesis, widely studied as a target in drug development for treating cancer. Several studies performed in the cardiovascular field on TSP-1 are contradictory, the role of TSP-1 in the physiopathology of cardiovascular disorders (CVDs) being, for the moment, incompletely understood and may be due to the presence of several domains in its structure which can stimulate many cellular receptors. It has been reported to inhibit NO-mediated signaling and to act on the angiogenesis, tissue perfusion, endothelial cell proliferation, and homeostasis, so we aimed to quantify the effect Perindopril has on TSP-1 plasma levels in hypertensive patients with endothelial dysfunction in comparison with other antihypertensive drugs, such as beta blockers, calcium channel blockers, and diuretics, in a chronic treatment. As a conclusion, patients under treatment with Perindopril had increased plasma levels of TSP-1 compared with other hypertensive patients and with the control group. The results of this study confirms the pleiotropic properties of Perindopril: anti-proliferative, anti-inflammatory, with effects showed by quantifying a single biomarker: TSP-1.

Regulation of Cellular Redox Signaling by Matricellular Proteins in Vascular Biology, Immunology, and Cancer

“…In vastus lateralis muscle samples from subjects with essential hypertension, TSP1 protein levels, as characterized by Western immunoblot, trended higher than those in controls but did not reach significance (62). In patients with hypertension, elevated plasma TSP1 was noted in association with decreased forearm-mediated vasodilation (18). However, in this study, TSP1 levels appeared elevated in controls compared to TSP1 levels reported in controls elsewhere (184), suggesting possible confounding by platelet activation.…”

MicroRNA‐194 reduces inflammatory response and human dermal microvascular endothelial cells permeability through suppression of TGF‐β/SMAD pathway by inhibiting THBS1 in chronic idiopathic urticaria

“…9 MiR-194 has been demonstrated to have an effect on suppressing tumor in a variety of cancers. 14,15 A study demonstrated that THBS1 is relevant to chronic ocular surface inflammation after refractive surgery. 13 THBS1, a pathological inhibitor of endogenous angiogenesis, is widely studied in the development of drug targets for the treatment of cancer and connected to several cellular functions.…”

The Utility of Different Types of Implants in Repairing Knee Joint Posttraumatic Lesions

“…The medication administered during hospitalization consisted of non-steroidal anti-inflammatory painkillers, according to the hospital protocols [7][8][9][10][11][12], with respect to any pre-existent conditions such as diabetes mellitus [13][14][15][16][17][18][19][20] or cardiovascular conditions such as arterial hypertension [21][22][23][24][25][26].…”