Perindopril is angiotensin-converting enzyme inhibitor in treatment patients with arterial hypertension

Objective. To investigate the impact of therapy with Mildronate® on the state of cerebral hemodynamics, on vascular wall remodeling and endothelial dysfunction in women with hypertension and estradiol deficiency. Subjects and methods. The investigation enrolled 37 patients (mean age, 43.0±3.5 years) with Stage I–II hypertension, reduced estradiol and elevated follicle-stimulating hormone (FSH) levels, who formed a study group. The patients in this group received Mildronate® in addition to standard therapy. A control group consisted of 38 healthy women (mean age 43.5±3.4 years) without chronic diseases affecting intracardiac and cerebral hemodynamics. Complete medical histories were taken from all the patients who underwent a mandatory laboratory test (including estradiol and FSH levels), ECG, and duplex scanning of the great cerebral arteries. Results. The features of vascular bed remodeling, the state of cerebral hemodynamics, and endothelial dysfunction in the examinees can assume that hypoestrogenemia may be a factor contributing to the progression of hypertension and the development of complications, such as cerebrovascular accidents. Conclusion. The study results have shown that Mildronate® is well tolerated by patients and is an effective treatment, showing a positive therapeutic effect on endothelium-dependent vascular relaxation, vascular remodeling, and whole-brain hemodynamics.

Impact of metabolic therapy on the state of cerebral hemodynamics in hypoestrogenemia

Khabibulina,

Shamilov

2023

Effect of FEMOKLIM on the state of blood vessels in hypoestrogenemia and arterial hypertension

Khabibulina,

Shamilov

2024

The article presents the results of duplex scanning of the common carotid arteries (CCA) and assessment of the structural and functional state of the vascular bed of 57 women with arterial hypertension (AH) with hypoestrogenemia. It was found that with hypertension with a reduced level of estradiol, the lumen of the OCA increases, the speed of blood flow in the carotid arteries decreases, which indicates vascular remodeling. In the studied patients, in every third case, an inertial type of vasomotor reaction is detected before treatment, which indicates the contribution of dishormonosis to the progression of hypertension due to the development of endothelial dysfunction. Combined therapy with phytoestrogens and ACE inhibitors improves the structural and functional characteristics of the vascular wall, reduces arterial stiffness. The drug Femoklim is a source of phytohormones, hormones of entomological origin and natural antioxidants, has a positive effect on the state of the vascular system, improves blood microcirculation, is a capillary protector, has a complex harmonizing effect on the body.

Effect of Equamer on cardialgia and psychoautonomic status in woman with metabolically healthy obesity, estrogen deficiency, and hypertension in the late fertile period

Khabibulina,

Shamilov

2023

A study group included 74 women with metabolically healthy obesity (MHO), estrogen-deficiency, and hypertension in the late fertile period (LFP); their mean age was 39.60±3.51 years) who was prescribed the antihypertensive agent Equamer as part of combination therapy. A control group consisted of 75 women with MHO in the LFP (their mean age was 39.50±3.49 years) with the normal level of estradiol and without hypertension. The study group was found to have an association of hypoestrogenism with psychoautonomic disorders, hypersymptopaticotonia, and cardialgia. After 6 months of therapy, the agent Equamer was shown to have a positive effect on the psychoautonomic status, the episodes of cardalgia in patients with estrogen-deficiency, MHO and hypertension in the LFP. Equamer has a high efficiency, is well tolerated by the patients (no adverse events were seen in the study), levels off the clinical manifestations of hypertension, normalizes blood pressure, lowers the body mass index, and exerts a complex harmonizing effect on a female organism.