Perineal talc exposure and epithelial ovarian cancer risk in the Central Valley of California

Mills, Paul K.; Riordan, Deborah G.; Cress, Rosemary D.; Young, Heather A.

doi:10.1002/ijc.20434

Cited by 58 publications

(52 citation statements)

References 28 publications

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“…Talc is structurally similar to asbestos, and studies have suggested that there are histologic similarities between serous adenocarcinomas and the mesotheliomas seen in asbestos exposure. These facts may explain findings of an increased risk of serous tumors in talc powder users [82]. Talc also can induce granulomas and other inflammatory responses in vivo [83] and a recent study found that exposing human ovarian stromal and epithelial cells to talc resulted in increased cell proliferation and neoplastic transformation of cells [84].…”

Section: Environmental Risk Factorsmentioning

confidence: 94%

Current Understanding of Risk Factors for Ovarian Cancer

Sueblinvong¹,

Carney²

2009

Curr. Treat. Options in Oncol.

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Ovarian cancer is the deadliest gynecologic cancer. Unlike many cancers such as breast, cervical and colon cancers, there is no easily clinically identifiable pre-malignant phase of this malignancy making early identification difficult. Similarly, unlike lung, head and neck, and skin cancers, there is not easily identifiable risk factor making prevention short of oophorectomy difficult. Even so, theories as to the causative factors of ovarian cancer continue to evolve making our understanding of the genesis of ovarian cancer more clear. Genetics, parity, environment, hormonal factors, and inflammation all play an important and pivotal role in the development of ovarian cancer. The most current understanding of these elements and their respective contribution to the development of this cancer are presented in this chapter.

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Section: Environmental Risk Factorsmentioning

confidence: 94%

Current Understanding of Risk Factors for Ovarian Cancer

Sueblinvong¹,

Carney²

2009

Curr. Treat. Options in Oncol.

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“…The summary relative risk for these studies in a meta-analysis (excluding Mills et al, 2004) is 1.33 [95% confidence intervals (CIs) 1.16-1.45] (Gross and Berg, 1995;Huncharek et al, 2003). Methodological issues such as response rates, validity, reliability, bias, the consistency of dose-response relationships, and causality have been reviewed elsewhere (Muscat and Barish, 1998).…”

Section: Introductionmentioning

confidence: 98%

“…The association between perineal talc powder dusting and ovarian cancer was determined in 16 case-control studies (Cramer et al, 1982(Cramer et al, , 1999Whittemore et al, 1988;Booth et al, 1989;Harlow and Weiss, 1989;Chen et al, 1992;Harlow et al, 1992;Tzonou et al, 1993;Purdie et al, 1995;Chang and Risch, 1997;Cook et al, 1997;Godard et al, 1998;Rosenblatt et al, 1998;Wong et al, 1999;Ness et al, 2000;Mills et al, 2004) and the Nurses' Health Study (Hankinson et al, 1993;Gertig et al, 2000). The summary relative risk for these studies in a meta-analysis (excluding Mills et al, 2004) is 1.33 [95% confidence intervals (CIs) 1.16-1.45] (Gross and Berg, 1995;Huncharek et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Perineal talc use and ovarian cancer: a critical review

Muscat

Huncharek

2008

European Journal of Cancer Prevention

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Talc, like asbestos, is a silicate that has been studied in relation to cancer risk. Several studies conducted over the past 25 years found an association between perineal talc powders and ovarian cancer. The summary relative risk is about 1.3 (95% confidence intervals 1.2-1.5) and these data have been interpreted as supporting a causal role. In this review article, we discuss the chemical and morphological features of talc and asbestos, and explain why despite their similar chemical classification talc does not possess asbestos-like carcinogenic properties. The heterogeneity in the perineal dusting studies has raised important concerns over the validity of the exposure measurements, and the lack of a consistent dose-response effect limits making causal inferences. Perhaps more importantly, whereas it is unknown whether external talc dust enters the female reproductive tract, measures of internal talc exposure such as talc-dusted diaphragms and latex condoms show no relationship with ovarian cancer risk. In addition, the therapeutic use of high dose cosmetic grade talc for pleurodesis has not been shown to cause cancer in patients receiving these treatment modalities. Talc is not genotoxic. Mechanistic, pathology and animal model studies have not found evidence for a carcinogenic effect. In summary, these data collectively do not indicate that cosmetic talc causes ovarian cancer.

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“…Eight of the population-based case-control studies11 16 22 – 24 26 28 29 were identified, by the IARC working group as being most informative in terms of size of the studies, whether the studies were population-based, participation rates and adjustments of confounding variables. The selected studies included at least 188 cases and had participation rates ranging from 60% to 75%.…”

mentioning

confidence: 99%

Perineal use of talc and risk of ovarian cancer

Langseth

Hankinson

Siemiatycki

et al. 2008

Journal of Epidemiology & Community Health

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Ovarian cancer is one of the most common gynaecological neoplasms, especially in industrialised countries. The aetiology of the disease is not well understood, except that inherited mutations in the breast cancer genes BRCA-1 and BRCA-2 account for up to 10% of all cases, 1 and child-bearing, oral contraceptive use and breast-feeding reduce the risk.2 Some environmental exposures, notably talc and asbestos, have been suspected as ovarian carcinogens.

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Perineal talc exposure and epithelial ovarian cancer risk in the Central Valley of California

Abstract: Perineal talc use has been suggested as a possible risk factor for ovarian cancer based on its structural similarity to asbestos, a known human carcinogen. A population-based epidemiologic case-control study of epithelial ovarian cancer (EOC) was conducted in 22

Cited by 58 publications

References 28 publications

Current Understanding of Risk Factors for Ovarian Cancer

Current Understanding of Risk Factors for Ovarian Cancer

Perineal talc use and ovarian cancer: a critical review

Perineal use of talc and risk of ovarian cancer

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