Perineural invasion in cervical cancer: pay attention to the indications of nerve-sparing radical hysterectomy

Zhu, Yi; Zhang, Guonan; Shi, Yu; Cui, Ling; Leng, Xuefeng; Huang, Jianming

doi:10.21037/atm.2019.04.35

Cited by 21 publications

(28 citation statements)

References 71 publications

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“…Evaluations of clinical specimens have also confirmed the presence of innervation in cervical cancer and ovarian cancer (Lucido et al, 2019;Kovacs et al, 2020;Reavis et al, 2020). In these evaluations, PNI in cervical cancer has a detection rate of 7.0% to 35.1% (Zhu et al, 2018;Zhu et al, 2019). Furthermore, existing studies suggest that there is a positive correlation between chronic stress and cancer progression.…”

Section: Introductionmentioning

confidence: 69%

Stress Hormones: Emerging Targets in Gynecological Cancers

Chen

Qiu²,

Gao

et al. 2021

Front. Cell Dev. Biol.

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In the past decade, several discoveries have documented the existence of innervation in ovarian cancer and cervical cancer. Notably, various neurotransmitters released by the activation of the sympathetic nervous system can promote the proliferation and metastasis of tumor cells and regulate immune cells in the tumor microenvironment. Therefore, a better understanding of the mechanisms involving neurotransmitters in the occurrence and development of gynecological cancers will be beneficial for exploring the feasibility of using inexpensive β-blockers and dopamine agonists in the clinical treatment of gynecological cancers. Additionally, this article provides some new insights into targeting tumor innervation and neurotransmitters in the tumor microenvironment.

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Section: Introductionmentioning

confidence: 69%

Stress Hormones: Emerging Targets in Gynecological Cancers

Chen

Qiu²,

Gao

et al. 2021

Front. Cell Dev. Biol.

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“…This phenomenon created a new compromise between the application of NSRH and the existence of PNI. Some authors disregard it and claim that NSRH should be the standard of care in CC surgery [1], while others state that since CC exhibits a tendency to PNI and is correlated with poor prognosis, the recommendations and guidelines for conducting NSRH need to be defined [2]. It means that coexistence of NSRH and conventional radical hysterectomy (CRH) is possible, and thus a system of coexistence is needed.…”

Section: Introductionmentioning

confidence: 99%

“…A total of 211 patients were randomized to NSRH (105 patients) or CRH (106 patients) [3][4][5][6]. Zhu et al found that the incidence of PNI in ESCC in eight reports amounted from 7% to 35.1% [2]. Having a closer look at the calculation of an average value of 16% in Wei et al, it appeared that in the group subjected to NSRH, 17 patients had PNI left in spared nerves, while in the CRH group, 89 out of 106 had dissected uninvolved nerves [7].…”

Section: Introductionmentioning

confidence: 99%

The Diagnosis of Perineural Invasion: A Crucial Factor in Novel Algorithm of Coexistence of Conventional and Nerve-Sparing Radical Hysterectomy

Skręt-Magierło

Książek

Gawlik³

et al. 2021

Diagnostics

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Nerve-sparing radical hysterectomy (NSRH) was introduced to mitigate adverse effects associated with conventional radical hysterectomy (CRH) in cervical cancer. However, the introduction of NSRH was compromised by possible existence of perineural invasion (PNI). Additionally, the coexistence of NSRH and CRH is currently the fact. The aim of the study was to review the literature and attempt to construct a novel and preliminary PNI diagnostic algorithm that would establish the coexistence of NSRH and CRH in one system of early-stage cervical cancer (ESCC) surgical treatment. This algorithm takes into account the PNI risk factors and current and future diagnostic methods such as imaging and biopsy.

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“…Perineural invasion was traditionally considered as the primary type of interaction between tumor cells and nerve cells in the tumor microenvironment, and is considered critical in the invasion and metastasis of pancreatic, colorectal and gastric cancer, as well as other malignant tumors (1,2). Previous studies showed that there is a new way of communication between tumor cells and nerve cells, which is called tumor cell-mediated neurogenesis (3)(4)(5)(6). In addition, newborn nerves stimulate the proliferation and metastasis of tumor cells.…”

Section: Introductionmentioning

confidence: 99%

“…In 2013, Magnon et al (5) confirmed that the sympathetic nerves could release norepinephrine to activate the β2 and β3 adrenergic receptors, leading to the onset of prostate cancer; whereas parasympathetic nerve-released acetylcholine could bind to type І muscarinic receptor to promote the proliferation and metastasis of prostate cancer. Since then, numerous pathological studies have observed the existence of newly developed nerves in a variety of malignant tumors (4)(5)(6)10,11). Although the associated mechanisms have not been elucidated yet, the understanding of cancer-related neurogenesis may provide a novel approach for cancer treatment.…”

Section: Introductionmentioning

confidence: 99%

Construction of differential expression plasmids of NGF to detect its influence on PC12 cell neuronal differentiation

et al. 2021

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Alongside angiogenesis and lymphangiogenesis, neurogenesis also occurs within the cancer microenvironment. Neurogenesis is a complex process involving multiple factors, among which nerve growth factor (NGF) possesses the dual biological roles of neuron nutrition and axon growth promotion. Thus, NGF might be a key molecule involved in regulating cancer-related neurogenesis, which could play a crucial role in the signal transmission system that controls nerve growth in tumors, and enhances the abilities of migration, invasion and metastasis of tumor cells. The present study aimed to construct differential expression plasmids of NGF, in order to detect whether NGF has a vital role in neurogenesis in breast cancer cells. In the present study, 92 clinical cases of breast cancer were collected and immunohistochemical analysis was performed to verify the existence of neurons in the breast cancer microenvironment. Furthermore, recombinant NGF lentiviral overexpression, knockout and silencing plasmids were constructed, and whether NGF has an effect on neuron growth was preliminarily confirmed, indicating that the successfully constructed plasmids could be used to verify the roles of NGF in cancer-associated neurogenesis.

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Perineural invasion in cervical cancer: pay attention to the indications of nerve-sparing radical hysterectomy

Cited by 21 publications

References 71 publications

Stress Hormones: Emerging Targets in Gynecological Cancers

Stress Hormones: Emerging Targets in Gynecological Cancers

The Diagnosis of Perineural Invasion: A Crucial Factor in Novel Algorithm of Coexistence of Conventional and Nerve-Sparing Radical Hysterectomy

Construction of differential expression plasmids of NGF to detect its influence on PC12 cell neuronal differentiation

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