Perineural Invasion Is an Independent Predictor of Outcome in Colorectal Cancer

Abstract

PNI is grossly underreported in CRC and could serve as an independent prognostic factor of outcomes in these patients. PNI should be considered when stratifying CRC patients for adjuvant treatment.

Clinico-pathological and oncological differences between right and left-sided colon cancer (stages I-III): analysis of 950 cases

“…The incidence of PNI and LVI was similar to that reported by other studies (33) and there were no significant differences between the two groups. With regard to the analyses of survival by stage, there were no differences in OS and DFS in stages I and II.…”

Perineural invasion in pT3N0 rectal cancer

“…10,14,28,29 In our study, we used the broad definition of PNI in pT3N0 rectal cancers, but we further studied the 2 tumor-nerve relationships (SS-PNI and TS-PNI) by analyzing their outcomes separately. Patients in the SS-PNI group and in the TS-PNI group both had significantly higher 5-year LR rates than that of the PNI-negative group, and a similar 5-year LR rate was also observed between the SS-PNI group and TS-PNI group.…”

“…7 The prognostic significance of PNI is widely advocated in malignancies of the head and neck and prostate, [8][9][10] but controversies exist in colorectal cancer. [11][12][13][14] In T1-2 early rectal cancer, PNI is one of the adverse pathologic features in selecting patients undergoing local excision. But whether it can be used as a criterion to select patients receiving chemoradiotherapy in T3N0 patients is still unknown to us.…”

Colon cancer surgery following emergency presentation: effects on admission and stage-adjusted outcomes

“…The pathological characteristics compared included the TNM classification, as well as pathological characteristics with prognostic significance. Poor prognostic factors compared included positive resection margins (expressed as R+), tumor grade (expressed as high-grade disease), extramural vascular invasion (EMVI), 8 perineural invasion, 9 infiltrating tumor border configuration 10 and absence of peritumoral lymphocytic response. 11 Inpatient characteristics which were analyzed included surgical duration, rates of laparoscopic surgery and conversion to open surgery, rates of multivisceral resection, and characteristics of the surgical admission including length of stay, rates of major surgical complications, and 30-day rates of readmission, reoperation, and death.…”