Perinuclear antineutrophilic cytoplasmic antibody–positive polyarteritis nodosa secondary to minocycline treatment for acne vulgaris

Gait, R.; Affleck, A.; Leach, I. H.; Varma, Sandeep

doi:10.1016/j.jaad.2007.05.032

Cited by 13 publications

(6 citation statements)

References 4 publications

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“…Minocycline or one of its metabolites may act as a "superantigen" leading to overactivation of the immune system, namely of lymphocytes, and release of proinflammatory cytokines, causing several autoimmune-related side effects, especially with chronic use [48,79]. These include drug reaction with eosinophilia and systemic symptoms (DRESS), autoimmune hepatitis, minocycline-induced lupus (MIL) [80] and/or exacerbation of systemic lupus erythematous (SLE), antinuclear antibodies (ANA) and antineutrophil cytoplasmic antibody-associated (ANCA) vasculitis [81], serum sickness-like reaction (SSLR), and other hypersensitivity reactions [21,82].…”

Section: Autoimmune-relatedmentioning

confidence: 99%

A Review of Systemic Minocycline Side Effects and Topical Minocycline as a Safer Alternative for Treating Acne and Rosacea

et al. 2021

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Resistance of Cutibacterium acnes to topical antibiotics historically used to treat acne (topical erythromycin and clindamycin and, more recently, topical azithromycin and clarithromycin) has been steadily increasing and new topical antibiotics are needed. Minocycline is a semisynthetic tetracycline-derived antibiotic currently used systemically to treat a wide range of infections caused by Gram-negative and Gram-positive bacteria. In addition to its antibiotic activity, minocycline possesses anti-inflammatory properties, such as the downregulation of proinflammatory cytokine production, suppression of neutrophil chemotaxis, activation of superoxide dismutase, and inhibition of phagocytosis, among others. These characteristics make minocycline a valuable agent for treatment of dermatological diseases such as acne vulgaris and papulopustular rosacea. However, more frequent or serious adverse effects have been observed upon the systemic administration of minocycline than with other tetracyclines. Examples of serious adverse effects include hypersensitivity syndrome reaction, drug-induced lupus, idiopathic intracranial hypertension, and other autoimmune syndromes that may cause death. Here, we review adverse effects and drug–drug interactions observed with oral administration of minocycline and contrast this with topical minocycline formulations recently approved or under development for effectively treating dermatological disorders with fewer adverse effects and less drug interaction.

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Section: Autoimmune-relatedmentioning

confidence: 99%

A Review of Systemic Minocycline Side Effects and Topical Minocycline as a Safer Alternative for Treating Acne and Rosacea

et al. 2021

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“…Manual analysis of the literature search since 2003 identified 106 publications reporting ADRs observed with tetracyclines, 7–112 including several epidemiological studies. Distributions of those cases according to tetracycline and ADR type are summarized in Table 6.…”

Section: Discussion and Literature Reviewmentioning

confidence: 99%

Comparative analysis of adverse drug reactions to tetracyclines: results of a French national survey and review of the literature

Lebrun‐Vignes

Kreft-Jaïs

Castot

et al. 2012

British Journal of Dermatology

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“…Immune deposits are usually very minimal or absent. Antineutrophil cytoplasmic antibodies (ANCAs) are typically negative, but patients with microscopic PAN may have ANCAs directed against myeloperoxidase 3 4…”

Section: Discussionmentioning

confidence: 99%

“…Minocycline-induced PAN most commonly affects the arteries of dermis and panniculus and causes palpable subcutaneous nodules, purpura and even ulceration 4 11–15. Frequent sites are finger and ankles.…”

Section: Discussionmentioning

confidence: 99%

Minocycline-induced renal polyarteritis nodosa

et al. 2012

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SummaryMinocycline is a bacteriostatic, long-acting, lipid-soluble tetracycline that is generally well tolerated, but has been associated with polyarteritis nodosa (PAN). This is a case report of a 21-year-old woman presented to her primary care physician with several months of fatigue, mylagias, weight loss and intermittent severe bi-temporal headaches without changes in vision. Her medications included an Ortho-Tri-Cyclen Lo and Minocycline, which she started 2 years prior for acne. On presentation, she was tachycardic and severely hypertensive. Initial laboratory evaluation showed hyponatraemia and hypokalaemia as well as elevation of inflammatory markers. Autoimmune work-up was positive for perinuclear antineutrophil cytoplasmic antibodies. Renal arteriogram was characteristic of PAN and along with her other symptoms, she fulfilled the necessary criteria of American College of Rheumatology for diagnosis of PAN. Minocycline as a possible causative agent was discontinued since it was reported to cause cutaneous PAN in the literature. Cyclophosphamide and prednisone were initiated for treatment of her vasulculitis. Her symptoms and hypertension improved over the next several months. This is the first report of the minocycline-induced renal PAN. BACKGROUND

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Perinuclear antineutrophilic cytoplasmic antibody–positive polyarteritis nodosa secondary to minocycline treatment for acne vulgaris

Cited by 13 publications

References 4 publications

A Review of Systemic Minocycline Side Effects and Topical Minocycline as a Safer Alternative for Treating Acne and Rosacea

A Review of Systemic Minocycline Side Effects and Topical Minocycline as a Safer Alternative for Treating Acne and Rosacea

Comparative analysis of adverse drug reactions to tetracyclines: results of a French national survey and review of the literature

Minocycline-induced renal polyarteritis nodosa

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