Perinuclear zone and diagonal band lesions enhance angiotensin responses of rat supraoptic neurons

Cunningham, J. Thomas; Nissen, R.; Renaud, Leo P.

doi:10.1152/ajpregu.1994.267.4.r916

Cited by 11 publications

(41 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…When a peripheral vasoconstrictor is delivered intravenously to increase blood pressure, vasopressinergic magnocellular neurones are inhibited. Ibotenic acid lesions, similar to those produced in this study, result in a decrease in the number of neurones inhibited by blood pressure increases (16, 23). In addition, in DBBX rats, the response of vasopressin‐secreting neurones to i.v.…”

Section: Discussionsupporting

confidence: 67%

Lesions of the Diagonal Band of Broca Enhance Drinking in the Rat

Sullivan

Cunningham

et al. 2003

J Neuroendocrinology

Self Cite

View full text Add to dashboard Cite

This study examined the role of the diagonal band of Broca (DBB) in drinking behaviour and vasopressin release. Adult male rats were anaesthetized (pentobarbital 50 mg/kg) and received DBB injections of either ibotenic acid (0.5 microl of 5 micro g/ microl) or vehicle (0.5 microl of phosphate-buffered saline). Although baseline drinking and urine output were not affected, drinking to 30% polyethylene glycol (MW 8000; 1 ml/100 g s.c.) and angiotensin II (0, 1.5 and 3.0 mg/kg s.c.) were significantly increased in ibotenic acid in phosphate-buffered saline (DBBX) rats. Drinking to hypertonic saline (0.9, 4 and 6%; 1 ml/100 g), and water deprivation were not significantly affected. DBBX rats had significantly lower basal heart rates than controls but the cardiovascular responses to infusions of angiotensin II (100 ng/kg/min i.v. for 45 min) were not affected. DBBX rats had significantly higher basal vasopressin, but angiotensin-stimulated vasopressin release was not significantly different. Although the DBB is not involved in basal water intake, it is involved in dipsogenic responses to hypovolemic stimuli and possibly basal autonomic function and basal vasopressin release.

show abstract

Section: Discussionsupporting

confidence: 67%

Lesions of the Diagonal Band of Broca Enhance Drinking in the Rat

Sullivan

Cunningham

et al. 2003

J Neuroendocrinology

Self Cite

View full text Add to dashboard Cite

show abstract

“…Further, sham water deglutition stimulates diuresis in anesthetized rats, and this effect is blocked by bilateral sectioning of the superior laryngeal nerve (58). Lastly, the NTS communicates extensively with a network of nuclei participating in cardiovascular regulation of vasopressin release that includes the diagonal band of broca (14,23), locus ceruleus (LC) (24), and parabrachial nucleus (PBN) (22). Therefore, these regions could participate in an alternative pathway involved in preabsorptive regulation of AVP and will be examined in our future endeavors.…”

Section: Effect Of Rehydration or Sham Rehydration On C-fos And Avpmentioning

confidence: 99%

“…The PNZ contains inhibitory interneurons (28,33,67) that reduce activity of phasic AVP neurons in the SON (4,14,25). We have previously demonstrated that c-Fos staining is increased in the PNZ following water but not saline rehydration (22).…”

Section: Effect Of Rehydration or Sham Rehydration On C-fos And Avpmentioning

confidence: 99%

Dehydration followed by sham rehydration contributes to reduced neuronal activation in vasopressinergic supraoptic neurons after water deprivation

Knight

Little

et al. 2010

American Journal of Physiology-Regulatory, Integrative and Comp

View full text Add to dashboard Cite

This experiment tested the role of oropharyngeal and gastric afferents on hypothalamic activation in dehydrated rats instrumented with gastric fistulas and allowed to drink water or isotonic saline compared with euhydrated controls (CON). Rats were water-deprived for 48 h (48 WD) or 46 h WD with 2 h rehydration with water (46+W) or isotonic saline (46+S). 46+W and 46+S rats were given water with fistulas open (46+WO/46+SO, sham) or closed (46+WC/46+SC). Compared with CON, water deprivation increased and water rehydration decreased plasma osmolality, while sham rehydration had no effect. Water deprivation increased c-Fos staining in the lamina terminalis. However, none of the sham or rehydration treatments normalized c-Fos staining in the lamina terminalis. Analysis of AVP and c-Fos-positive neurons in the supraoptic nucleus (SON) revealed reduced colocalization in 46+WO and 46+SC rats compared with 48 WD and 46+SO rats. However, 46+WO and 46+SC rats had higher c-Fos staining in the SON than 46+WC or CON rats. Examination of c-Fos in the perinuclear zone (PNZ) revealed that sham and rehydrated rats had increased c-Fos staining to CON, while 48 WD and 46+SO rats had little or no c-Fos staining in this region. Thus, preabsorptive reflexes contribute to the regulation of AVP neurons in a manner independent of c-Fos expression in the lamina terminalis. Further, this reflex pathway may include inhibitory interneurons in the PNZ region surrounding the SON.

show abstract

“…In addition, another receptor with a high affinity for NPFF, namely, NPFF2 (FF2; Bonini et al, 2000;Elshourbagy et al, 2000), also is not expressed in the human SO . However, high numbers of NPFF fibers in the PNZ might be involved in indirect regulation of SO neurons, in that studies in the rat have shown that an interneuronal network located in the PNZ affects the activity of neurosecretory neurons within the SO (Jhamandas et al, 1991;Cunningham et al, 1994;Herbison, 1994).…”

Section: Distribution Of Npff In the Human Forebrainmentioning

confidence: 99%

Neuropeptide FF distribution in the human and rat forebrain: A comparative immunohistochemical study

Goncharuk

Buijs

MacTavish

et al. 2006

J of Comparative Neurology

View full text Add to dashboard Cite

Neuropeptide FF (NPFF) is an octapeptide implicated in a variety of physiological functions, including nociception, cardiovascular responses, and neuroendocrine regulation. The NPFF gene and its mRNA are highly conserved across species. A comparative study of NPFF distribution in the human and rat forebrain was carried out by using single NPFF and double NPFF + vasopressin (VP) immunohistochemistry. NPFF is extensively localized within neurochemical circuits of human and rat forebrain. Semiquantitative analysis revealed that the densities of NPFF cells and fibers in many forebrain nuclei in the human correlate well with those observed for the same structures in the rat. High numbers of NPFF positive neurons in the dorsomedial hypothalamic nucleus and a dense plexus of NPFF fibers surrounding the fornix within the bed nucleus of the stria terminalis were identified in the human and rat forebrain. Within the hypothalamus of both species, dense NPFF innervation was observed in the perinuclear zone of the supraoptic nucleus (SO) just dorsolateral to the VP-positive neurons. Extensive NPFF innervation of ventricular ependyma and brain microvasculature were common for both species. At the same time, obvious differences in NPFF localization between the two species were also apparent. For example, in contrast to the rat SO, no NPFF- or NPFF- + VP-immunostained cells were observed in the human SO. Knowledge of NPFF neuroanatomical localization in the human brain and the relationship of these observations to those in the rat brain may provide insight into the role of this peptide in central cardiovascular and neuroendocrine regulation.

show abstract

Perinuclear zone and diagonal band lesions enhance angiotensin responses of rat supraoptic neurons

Cited by 11 publications

References 0 publications

Lesions of the Diagonal Band of Broca Enhance Drinking in the Rat

Lesions of the Diagonal Band of Broca Enhance Drinking in the Rat

Dehydration followed by sham rehydration contributes to reduced neuronal activation in vasopressinergic supraoptic neurons after water deprivation

Neuropeptide FF distribution in the human and rat forebrain: A comparative immunohistochemical study

Contact Info

Product

Resources

About