Periocular Melanoma In Situ Treated With Imiquimod

Elia, Maxwell; Lally, Sara E.; Hanlon, Allison; Choi, Jennifer N.; Servat, Juan Javier; Shields, Jerry A.; Shields, Carol L.; Levin, Flora

doi:10.1097/iop.0000000000000554

Cited by 24 publications

(20 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Management of conjunctival PAM (in absence of LM/LMM) with IFN ophthalmic solution was already described by one of our co‐authors . The third one is a very recently published series of 12 cases of periocular LM melanoma subtype treated with topical imiquimod daily for a mean period of 3.9 months as single therapy or in combination with surgery and/or cryotherapy at different treatment regimens . The series included three cases of LMM whose invasive area was excised prior to imiquimod therapy.…”

Section: Discussionmentioning

confidence: 99%

Immunocryosurgery as monotherapy for lentigo maligna or combined with surgical excision for lentigo maligna melanoma

Matas‐Nadal

Soria

García‐de‐la‐Fuente

et al. 2018

The Journal of Dermatology

View full text Add to dashboard Cite

The incidence of lentigo maligna (LM), in situ (LM) or invasive (lentigo maligna melanoma, LMM), has increased during the last decades. Due to functional or cosmetic outcomes, optimal treatment with surgical excision may not be appropriate in some cases. We tried less invasive therapy, immunocryosurgery, as a single treatment for LM or combined with surgery for LMM, with better aesthetic results. Three patients with LM or LMM not amenable to complete surgical excision were selected. LMM patients underwent limited surgical resection of the invasive area. Subsequently, a combined treatment with topical imiquimod and cryosurgery was performed. The LM patient received immunocryosurgery directly. All of them were free of local and systemic disease at 48, 42 and 41 months after discontinuation of therapy. We consider that immunocryosurgery is an alternative option for LM or even for LMM (after removal of the invasive tissue with narrow margins) in poor surgical candidates, with good therapeutic, functional and cosmetic results.

show abstract

Section: Discussionmentioning

confidence: 99%

Immunocryosurgery as monotherapy for lentigo maligna or combined with surgical excision for lentigo maligna melanoma

Matas‐Nadal

Soria

García‐de‐la‐Fuente

et al. 2018

The Journal of Dermatology

View full text Add to dashboard Cite

show abstract

“…3 Other eyelid lesions such as Bowen's disease, actinic keratosis, lentigo maligna, melanoma in situ, and squamous cell carcinoma (SCC) have been treated with topical application of imiquimod 5% cream. [4][5][6][7] Although the manufacturer recommends that this cream not be used in the periocular region, cautious application only to the lesion has delivered promising results. 8 Surgical excision of eyelid malignancy with histopathological free margins followed by eyelid reconstruction still is considered the gold standard by many surgeons, but in difficult areas such as the medial canthus region, non-surgical treatment modalities have been attempted.…”

Section: Treatment Of Squamous Cell Carcinoma Of the Eyelid With Imiqmentioning

confidence: 99%

“…2,3 Such clinical features are shared in common with mitochondrial disorders such as Leber's hereditary optic neuropathy (LHON) and suggest adjunctive etiologies involving mitochondrial dysfunction and mitochondrial DNA (mtDNA) in WS pathophysiology. [6][7][8][9][10][11][12] Microvascular changes in the optic nerve head (ONH) and peripapillary retinal blood supply have been demonstrated in well-established mitochondrial diseases such as Leber's hereditary optic neuropathy (LHON) and dominant optic atrophy (DOA). 13 The advent of a new optical coherence tomography (OCT) technology, called…”

Section: Optical Coherence Tomographyangiography In Wolfram Syndrome:mentioning

confidence: 99%

Treatment of squamous cell carcinoma of the eyelid with imiquimod 5% cream

Singh

Kakkar

et al. 2019

Canadian Journal of Ophthalmology

View full text Add to dashboard Cite

histopathology and immune histochemical aspects of the ductal tumours-they did not mention the outcome of the disease in that patient. 2 Similarly, there are two other reports describing the orbital metastasis in case of a mixed parotid tumour and polymorphous low-grade adenocarcinoma of the parotid glands. 3,4 After orbital exenteration, the examination of the specimen under the microscope revealed a larger poorly differentiated tumour mass eroding the ocular coats with a posterior extension invading the proximal part of the optic nerve; however, the resected posterior end of the optic nerve and rest of the margins were free of tumour cells. Immunological stains for cytokeratin, epithelial membrane antigen, and cytokeratin 7 were positive, whereas reactivity for S-100 proteins, estrogen receptors, progesterone receptors were negative. To conclude, the primary salivary duct carcinoma of the salivary gland remained asymptomatic clinically as well as radiologically for 18 months. Thus orbital tumours with unusual presentations need a detailed evaluation with close follow-up to counter the problems related to a primary tumour elsewhere in the body at the earliest, thereby helping to reduce systemic morbidity and mortality.

show abstract

“…6 Combination of imiquimod with cryosurgery as a double topical treatment has been described as a nonsurgical alternative for LM, demonstrating good oncological, functional, and esthetic results. 1,2,4,7,8 We postulate that this regimen of immunocryosurgery results in low patient morbidity with ideal esthetic outcomes, and could be considered as an alternative for LM in those patients not suitable for surgery. However, this is a preliminary study, and more data are needed from a larger number of patients.…”

mentioning

confidence: 99%

“…However, this is a preliminary study, and more data are needed from a larger number of patients. Several different immunocryosurgery schemes have been reported, 1,2,4,7,8 and therapy standardization remains a pivotal point.…”

mentioning

confidence: 99%