Periocular tumour of the follicular infundibulum

Abstract

Tumour of the follicular infundibulum (TFI) is an uncommon, benign lesion of the skin adnexae. Four cases are reported of periocular TFI. In all cases a clinical diagnosis of basal cell carcinoma was made before surgery; however, histopatholog ca examination revealed TFI. This is an epithelial tumour showing differentiation along the lines of the follicular infundibulum. Characteristic features are a shelf-like proliferat on of pale epithelia cells in the upper dermis, attachment to the epidermis and the upper portions of the pilosebaceous units, a dense border of elastic fibres, and palisading of the peripheral cell layer of the tumour plate. This benign tumour has not, to the authors' knowledge, been reported in the ophthalmic literature. It has a non-specific appearance and may be clinically misdiagnosed as naevus sebaceous, xanthoma, seborrhoeic keratosis, or basal cell carcinoma.

Tumor of follicular infundibulum–associated neoplasms

“…Since the discovery of TFI in 1961, there have been many accounts of associated neoplasms ( Table I ). 9 , 13 , 14 , 15 , 16 , 17 , 19 , 20 , 21 One of the first mentions of TFI-associated lesions was in 1989, by Kossard et al. 6 In studying eruptive infundibulomas, they found that the platelike epithelial architecture of TFI was seen in association with seborrheic keratoses and BCC.…”