2009
DOI: 10.1016/j.jmb.2009.04.071
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Periodic Forces Trigger a Complex Mechanical Response in Ubiquitin

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Cited by 12 publications
(6 citation statements)
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“…One of the recent applications of SMD is to understand the mechanism of virus binding to its host cell (Sieben et al 2012). Another issue of great interest is the application of SMD for studying the response of protein to periodic forces (Szymczak and Janovjak 2009). It is also worth to mention some important problems for further studies.…”
Section: Mechanical Unfolding Of Proteinsmentioning
confidence: 99%
“…One of the recent applications of SMD is to understand the mechanism of virus binding to its host cell (Sieben et al 2012). Another issue of great interest is the application of SMD for studying the response of protein to periodic forces (Szymczak and Janovjak 2009). It is also worth to mention some important problems for further studies.…”
Section: Mechanical Unfolding Of Proteinsmentioning
confidence: 99%
“…We did not take into account Brownian ratchet effects nor did we account for the fact that the real biological forces produced by the motors are always cyclic in character, since the motors transform chemical energy into directed motions via nucleotide-hydrolysis-mediated conformational changes. These effects can significantly affect the unfolding pathways [32,33]. Whether this can prevent the knot from tightening is the subject of further study.…”
Section: Implications For Protein Translocationmentioning
confidence: 99%
“…Williams and Jankowsy [10] showed that viral RNA helicase NPH-II hops cyclically from the ds to the ss part of DNA and back during the ATP hydrolysis cycle. Apart from these examples, there are several studies [11][12][13][14], which suggest that the force acting on DNA (at the junction of the Y fork i.e. ssDNA and dsDNA)…”
mentioning
confidence: 99%