Periodic Meningitis and Familial Mediterranean Fever

Vilaseca, J; Tor, Jordina; Guàrdia, J; Bacardí, R

doi:10.1001/archinte.1982.00340150178031

Cited by 10 publications

(6 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Barakat et al (1988) have suggested that MM in many ways resembles FMF in its natural history, pattern of attacks, and a good response to colchicine. The association of these two conditions has been reported so far in four patients (Vilaseca, Tor, Guardia, & Bacardi, 1982;Barakat et al, 1988;Collard, Sellal, Hirsch, Mutschler, & Marescaux, 1991). Provocative infusion of metaraminol induced the symptoms of these two entities, both in adults and children (Barakat, El-Khawad, Gumaa, El-Sobki, & Fenech, 1984;Barakat et al, 1988;Huppertz & Michels, 1988).…”

Section: Metaraminolmentioning

confidence: 82%

Mollaret Meningitis may be Caused by Reactivation of Latent Cerebral Toxoplasmosis

Prandota

2009

International Journal of Neuroscience

View full text Add to dashboard Cite

Mollaret meningitis (MM) occurs mainly in females and is characterized by recurrent episodes of headache, transient neurological abnormalities, and the cerebrospinal fluid containing mononuclear cells. HSV-2 was usually identified as the causative agent. Recently, we found that recurrent headaches in non-HIV-infected subjects were due to acquired cerebral toxoplasmosis (CT). The aim of the study was therefore to focus on molecular pathomechanisms that may lead to reactivation of latent CT and manifest as MM. Literature data cited in this work were selected to illustrate that various factors may affect latent CNS Toxoplasma gondii infection/inflammation intensity and/or host defense mechanisms, i.e., the production of NO, cytokines, tryptophan degradation by indoleamine 2,3-dioxygenase, mechanisms mediated by an IFN-gamma responsive gene family, limiting the availability of intracellular iron to T. gondii, and production of reactive oxygen/nitrogen species, finally inducing choroid plexitis and/or vasculitis. Examples of triggers revealing MM and accompanying disturbances of IFN-gamma-mediated immune responses that control HSV-2 and T. gondii include: female predominance (female mice are more susceptible to T. gondii infection than males); HSV-2 infection (increased IFN-gamma, IL-12); metaraminol (increased plasma catecholamine levels, changes in cytokine expression favoring T(H)2 cells responses); probably cholesterol contained in debris from ruptured epidermoid cysts (decreased NO; increased TNF-alpha, IL-6, IL-8). These irregularities induced by the triggers may be responsible for reactivation of latent CT and development of MM. Thus, subjects with MM should have test(s) for T. gondii infection performed obligatorily.

show abstract

Section: Metaraminolmentioning

confidence: 82%

Mollaret Meningitis may be Caused by Reactivation of Latent Cerebral Toxoplasmosis

Prandota

2009

International Journal of Neuroscience

View full text Add to dashboard Cite

show abstract

“…Abdominal attacks are reported in 90%, articular symptoms in 75% and pleural involvement in 45% of the affected individuals along with the fever. Various atypical presentations such as recurrent isolated monoarthritis, isolated pleuritis and pericarditis, recurrent urticaria and meningitis have been reported [3][4][5][6][7][8][9][10].…”

Section: Discussionmentioning

confidence: 99%

Orbital muscle involvement in a child with familial Mediterranean fever

Keskindemirci¹,

Ayaz²,

Çakan³

et al. 2016

MMJ

View full text Add to dashboard Cite

Familial Mediterranean fever is an autosomal recessively inherited autoinflammatory disorder characterized by recurrent attacks of fever, serositis and synovitis. Various atypical presentations have been reported in the literature. Herein, we report a case of orbital myositis presenting with acute and devastating ocular symptoms resembling orbital cellulitis in a 12-year-old boy with familial Mediterranean fever.

show abstract

“…However, despite this low transportation, Col may be useful in some intracranial inflammatory conditions. For example, Col may have a beneficial effect in patients with FMF with recurrent meningitis called Mollaret’s meningitis ( 50 , 51 ). This example demonstrates that Col, even at therapeutic doses, may be beneficial in FMF-related intracerebral inflammatory conditions.…”

Section: The Effect Of Colchicine On the Central Nervous Systemmentioning

confidence: 99%

A Hypothesis Regarding Neurosecretory Inhibition of Stress Mediators by Colchicine in Preventing Stress-Induced Familial Mediterranean Fever Attacks

Korkmaz

Cansu²

2022

Front. Immunol.

View full text Add to dashboard Cite

Familial Mediterranean fever (FMF) is a monogenic autoinflammatory disease characterized by recurrent episodes of fever and serositis. Colchicine (Col) has a crucial role in the prevention of amyloidosis and FMF attacks. The effect of Col on innate immune cells is based on the inhibition of the microtubule system. The microtubule system is also very important for neurosecretory functions. The inhibitory effect of Col on neurosecretory functions is an overlooked issue. Considering that the neuroimmune cross-talk process plays a role in the development of inflammatory diseases, the effect of Col on the neuronal system becomes important. FMF attacks are related to emotional stress. Therefore, the effect of Col on stress mediators is taken into consideration. In this hypothetical review, we discuss the possible effects of Col on the central nervous systems (CNS) and peripheral nervous systems (PNS) in light of mostly experimental study findings using animal models. Studies to be carried out on this subject will shed light on the pathogenesis of FMF attacks and the other possible mechanisms of action of Col apart from the anti-inflammatory features.

show abstract

Periodic Meningitis and Familial Mediterranean Fever

Cited by 10 publications

References 0 publications

Mollaret Meningitis may be Caused by Reactivation of Latent Cerebral Toxoplasmosis

Mollaret Meningitis may be Caused by Reactivation of Latent Cerebral Toxoplasmosis

Orbital muscle involvement in a child with familial Mediterranean fever

A Hypothesis Regarding Neurosecretory Inhibition of Stress Mediators by Colchicine in Preventing Stress-Induced Familial Mediterranean Fever Attacks

Contact Info

Product

Resources

About