Periodic ophthalmia (recurrent uveitis) of horses: An evaluation of the aetiological role of microfilariae of <i>Onchocerca cervicalis</i> and the clinical management of the condition

Attenburrow, D. P.; Donnelly, John; Soulsby, E. J. L.

doi:10.1111/j.2042-3306.1983.tb04559.x

Cited by 13 publications

(6 citation statements)

References 10 publications

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“…1,7,16 O. cervicalis is the frequently reported species in horses. 2,8,[11][12][13] The cattle filariid, O. gutturosa, has not been reported in donkeys but rare reports exist in the nuchal ligament of the horse. 15 The only Onchocerca sp.…”

mentioning

confidence: 99%

Suspensory Ligament Desmitis Caused by Onchocerca sp. in Three Donkeys

Paraschou

Adako²,

Priestnall

et al. 2020

Vet Pathol

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Three donkeys were presented with progressive lameness and distal suspensory ligament breakdown in multiple limbs. Treatment with nonsteroidal anti-inflammatory drugs was only partially effective and eventually the donkeys were euthanized due to further progression of the lameness and concerns for their welfare. At necropsy, the distal part of the suspensory ligaments in multiple limbs, including the suspensory ligament branches, was markedly thickened, enlarged, and mottled white and brown on cut section. In one case, adult Onchocerca sp. nematodes were grossly identified embedded within the suspensory ligaments. Histopathologic examination revealed chronic, multifocal to coalescing, moderate to severe, lymphoplasmacytic, eosinophilic, and fibrosing desmitis and tendinitis with intralesional, coiled adult nematodes of Onchocerca sp., accompanied by osseous and cartilaginous metaplasia. To the authors’ knowledge, this is the first histopathologic description of suspensory ligament desmitis and tendinitis associated with Onchocerca sp. in donkeys.

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mentioning

confidence: 99%

Suspensory Ligament Desmitis Caused by Onchocerca sp. in Three Donkeys

Paraschou

Adako²,

Priestnall

et al. 2020

Vet Pathol

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“…40 In particular, Onchocerca cervicalis and other Onchocerca species have been linked with uveitis in humans and horses. 8,78,79 Connections between uveitis and infection of Setaria or Halicephalobus species have also been reported in horses. 46,[80][81][82][83][84] However, case reports indicate that infections of Setaria, Halicephalobus, and Onchocerca species are not major risk factors for recurrent uveitis in horses as inflammation often resolves after treatment (Setaria and Onchocerca) or affected individuals do not survive the infection (Halicephalobus).…”

Section: Other Infectious Risk Factorsmentioning

confidence: 98%

“…Although several parasites have also been implicated for inciting equine uveitis, current evidence suggests that uveitis secondary to infection is usually rare as the parasitic organisms must infiltrate ocular structures to trigger inflammation within the eye 40 . In particular, Onchocerca cervicalis and other Onchocerca species have been linked with uveitis in humans and horses 8,78,79 . Connections between uveitis and infection of Setaria or Halicephalobus species have also been reported in horses 46,80–84 .…”

Section: Environmental Risk Factorsmentioning

confidence: 99%

A review of investigated risk factors for developing equine recurrent uveitis

Kingsley

Sandmeyer

2022

Veterinary Ophthalmology

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Equine recurrent uveitis (ERU) is an ocular inflammatory disease that can be difficult to manage clinically. As such, it is the leading cause of bilateral blindness for horses. ERU is suspected to have a complex autoimmune etiology with both environmental and genetic risk factors contributing to onset and disease progression in some or all cases. Work in recent years has aimed at unraveling the primary triggers, such as infectious agents and inherited breed-specific risk factors, for disease onset, persistence, and progression. This review has aimed at encompassing those factors that have been associated, implicated, or substantiated as contributors to ERU, as well as identifying areas for which additional knowledge is needed to better understand risk for disease onset and progression.A greater understanding of the risk factors for ERU will enable earlier detection and better prognosis through prevention and new therapeutics.

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“…This view was still supported half a century later (Jones 1942, 1949). Viral involvement in ERU has been suspected but has never been proven (Komar and Szutter 1968; Attenburrow et al 1983).…”

Section: Aetiology Of Equine Recurrent Uveitis (Eru)mentioning

confidence: 99%

“…At one point microfilariae of Onchocerca cervicalis were thought to play a role in the aetiology of ERU, although today this seems to be rather exceptional (Gmelin 1935; Attenburrow et al 1983; Cook and Harling 1983; van der Velden and Schuitemaker 1985).…”

Section: Aetiology Of Equine Recurrent Uveitis (Eru)mentioning

confidence: 99%

Equine recurrent uveitis: The European viewpoint

Spiess

2010

Equine Veterinary Journal

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Summary Equine recurrent uveitis (ERU) has always been and still is an important disease with a significant impact on the horse industry in Europe, with a prevalence of 8–10%. The need to understand and manage the disease has spurred the development of veterinary ophthalmology in general, although the aetiology of the disease remains the subject of intense discussion. It is most probably an autoimmune disease triggered, at least in Europe, in the majority of cases by Leptospira spp. The therapy of ERU has evolved over the centuries from various methods of bloodletting to rational medical therapy using mydriatics and steroidal and nonsteroidal anti‐inflammatory drugs, to surgical therapies, such as vitrectomy or implantation of cyclosporin‐releasing devices. In Europe, pars plana vitrectomy in horses testing positive for Leptospira spp. appears to be the most successful form of therapy at the present time.

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Periodic ophthalmia (recurrent uveitis) of horses: An evaluation of the aetiological role of microfilariae of Onchocerca cervicalis and the clinical management of the condition

Cited by 13 publications

References 10 publications

Suspensory Ligament Desmitis Caused by Onchocerca sp. in Three Donkeys

Suspensory Ligament Desmitis Caused by Onchocerca sp. in Three Donkeys

A review of investigated risk factors for developing equine recurrent uveitis

Equine recurrent uveitis: The European viewpoint

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