By exhibiting the corresponding Lax-pair representations, we propose a wide class of integrable twodimensional (2D) fermionic Toda lattice (TL) hierarchies, which includes the 2D N =(2|2) and N =(0|2) supersymmetric TL hierarchies as particular cases. We develop the generalized graded R-matrix formalism using the generalized graded bracket on the space of graded operators with involution generalizing the graded commutator in superalgebras, which allows describing these hierarchies in the framework of the Hamiltonian formalism and constructing their first two Hamiltonian structures. We obtain the first Hamiltonian structure for both bosonic and fermionic Lax operators and the second Hamiltonian structure only for bosonic Lax operators.