Periodicity in Protein Metabolism: Time Patterns of Substrate Interaction and Utilization

Berrizbeitia, Luis D.; Moore, Francis D.

doi:10.1177/0148607183007004398

Cited by 5 publications

(1 citation statement)

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“…Consequently, the energetic stores of the body are progressively drained to support the tumor metabolism and the tumor acts as an “energy sink.” A large aliquot of dietary amino acids is used by the tumor to sustain the increased turnover of its own protein and by the liver of the tumor host to synthesize more gluconeogenetic enzymes. Also, neoplastic protein synthesis does not respect the circadian rhythm observed in the protein synthesis of normal tissues, with enhancement during alimentary absorption and inhibition in the post‐absorptive period 20 . The uninhibited synthesis of the tumor protein in the postabsorptive period is maintained with amino acids obtained by proteolysis in normal tissues.…”

Section: Cancer Cachexiamentioning

confidence: 96%

Nutrition, Cancer, and Aging: An Annotated Review

Hardy

Wallace

Khansur

et al. 1986

J American Geriatrics Society

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The interactions of cancer and malnutrition are discussed with the focus on aging. To establish whether the elderly are more likely to develop cancer cachexia and its complications, this review encompasses the pathogenesis of malnutrition in cancer; the age-related alterations of appetite, gastrointestinal function, energy expenditure, and protein turnover; the diagnosis of malnutrition; and the effectiveness of nutritional support in the elderly. Although metabolic and physiologic changes induced by cancer and age appear synergistic in causing cachexia, more frequent complications of malnutrition have not been observed in the geriatric cancer patients. This may be due to only a small proportion of the elderly with cancer being enrolled in clinical studies or to a reduced cachexia-inducing ability of tumors in these patients. A limited number of studies indicate nutritional replenishment is obtainable in malnourished elderly by hyperalimentation. As restoration of the lean body mass may be slower in older patients, early institution of nutritional support is recommended in malnourished elderly or elderly at risk for malnutrition during neoplastic treatment.

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Section: Cancer Cachexiamentioning

confidence: 96%