Periodontal and caries status in unexplained female infertility: A case–control study

Telatar, Gül Yıldız; Gürlek, Beril; Telatar, Bariş Can

doi:10.1002/jper.20-0394

Cited by 10 publications

(9 citation statements)

References 42 publications

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“…Thus we can explain a smaller number of positive tests. This is inconsistent with published studies that have shown poorer periodontal status in patients with idiopathic infertility ( 1 , 8 , 10 , 12 ). A possible explanation might be that infertile women included in our study were more aware of their oral health, or that they had different economic or educational background which might also affect their oral health, which was not considered in this study.…”

Section: Discussioncontrasting

confidence: 90%

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Diagnostic Accuracy of Salivary aMMP-8 Test in Infertile Women and Blood Finding Analysis

Šumilin¹,

Musić²,

Puhar³

et al. 2022

Acta Stomatol Croat

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Introduction The literature reviewed in this paper suggests that infertile patients present worse periodontal status, which may be causative to conception complications. This study aimed to validate an aMMP-8 point-of-care mouth rinse test in the population of women with unexplained infertility and compare it to age-matched fertile women with and without periodontitis. Furthermore, blood sampled inflammatory parameters were analyzed and compared between the two groups. It was hypothesized that the infertile women would present worse periodontal status and a greater number of positive aMMP-8 tests than fertile women, and they would have increased inflammatory blood parameters. Material and methods The study included 50 healthy norm-ovulatory females aged 25-45 years with strictly defined unexplained (idiopathic) infertility, and 50 healthy norm-ovulatory women of the same age who had conceived and delivered naturally. Results The sensitivity and specificity of the test for detecting periodontitis was 84% and 72% in the group of infertile patients, 88% and 68% in the group of fertile patients and 86% and 70% in the overall patient population. Infertile patients with periodontitis had less advanced periodontitis than the control group although this difference was not statistically significant. Blood inflammatory markers were significantly higher in infertile than in fertile women. Conclusion This study has shown that infertile patients had better periodontal status and less advanced periodontitis than fertile women of the same age. Therefore, when interpreting the results of aMMP-8 tests for diagnosis of periodontitis, one should keep in mind the periodontal status of the examined population.

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Section: Discussioncontrasting

confidence: 90%

“…Some authors have shown worse periodontal status in infertile patients and suspected that this is a factor that complicates conception ( 1 , 6 - 10 , 12 ). On the contrary, others have reported that the periodontal status of patients has not affected the outcome of the IVF procedure ( 31 ).…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Accuracy of Salivary aMMP-8 Test in Infertile Women and Blood Finding Analysis

Šumilin¹,

Musić²,

Puhar³

et al. 2022

Acta Stomatol Croat

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“…All included studies were published between 1994 and 2022. The characteristics of these 18 studies were shown in Table 1 , including 10 studies [ 26 – 35 ] in relative to the prevalence of caries in patients with periodontitis, 5 [ 29 – 32 , 36 ] containing the prevalence of periodontitis in patients with caries and 7 studies [ 33 , 37 – 42 ] covering the association between pathogenic bacteria related to two diseases.…”

Section: Resultsmentioning

confidence: 99%

Association between periodontitis and dental caries: a systematic review and meta-analysis

Li,

Xiang,

Ren

et al. 2024

Clin Oral Invest

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Objectives Recent evidence suggested a link between periodontitis (PD) and dental caries, but the trends and nature of this association remained unclear. The overall aim of this study was to critically assess the correlation of two disorders. Methods A comprehensive search was conducted within the PUBMED and EMBASE databases including grey literatures up to July 5th, 2023. The Newcastle–Ottawa scale was used to qualitatively evaluate the risk of bias. Results Overall, 18 studies were included. In terms of caries risk in PD patients, the prevalence of caries was increased by PD (OR = 1.57, 95%CI:1.20–2.07), both in crown (OR = 1.03, 95%CI:1.01–1.05) and root caries (OR = 2.10, 95%CI:1.03–4.29). Odds of caries were also raised by PD severity (OR moderate = 1.38, 95%CI:1.15–1.66; OR severe = 2.14, 95%CI:1.74–2.64). Besides, patients with PD exhibited a higher mean number of decayed, missing and filled teeth (DMFT) and decayed and filled root teeth (DFR) [weighted mean difference (WMD)DMFT = 0.87, 95%CI: -0.03–1.76; WMDDFR = 1.13, 95%CI: 0.48–1.78]. Likewise, patients with caries had an elevated risk of PD (OR = 1.79, 95%CI:1.36–2.35). However, Streptococcus mutans, one of the main pathogens of caries, was negatively correlated with several main pathogens of periodontitis. Conclusions This study indicated a positive correlation between dental caries and periodontitis clinically, while the two disease-associated pathogens were antagonistic. Clinical relevance Further research, including clinical cohort studies and mechanisms of pathogens interaction is needed on this link for better prevention and treatment of PD and caries. In addition, innovative prevention strategies need to be developed and incorporated in dental practices to prevent these two highly prevalent oral diseases.

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“…Furthermore, beyond its impact on periodontal tissues, periodontitis also has implications for other bodily systems. Some observational studies have shown that periodontitis may pose potential risks for female reproductive difficulties and adverse pregnancy outcomes, such as female infertility [ 4 ], endometriosis [ 5 ], spontaneous miscarriages occurring before 20 weeks of gestation [ 6 ], and the delivery of low-weight babies, defined as those weighing less than 2.5 kg at birth [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Maternal periodontitis may cause lower birth weight in children: genetic evidence from a comprehensive Mendelian randomization study on periodontitis and pregnancy

Chen,

Li,

Yang

et al. 2024

Clin Oral Invest

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Objectives This study aims to comprehensively investigate the potential genetic link between periodontitis and adverse pregnancy outcomes using a two-sample Mendelian Randomization approach. Materials and methods We employed robust genetic instruments for chronic periodontitis as exposure data from the FinnGen database. Data encompassing various pregnancy stage outcomes, including pre-pregnancy conditions (irregular menstruation, endometriosis, abnormal reproductive bleeding, and female infertility), pregnancy complications (hemorrhage, spontaneous miscarriage, and abnormalities in products), and post-pregnancy factors (single spontaneous delivery, labor duration, and birth weight of the child), were obtained from the UK Biobank. The random-effects inverse-variance weighted (IVW) method was utilized to compute primary estimates while diligently assessing potential directional pleiotropy and heterogeneity. Results Our findings indicate a negative association between periodontitis and labor duration (odds ratio [OR] = 0.999; 95% confidence interval [CI]: 0.999 to 1.000; P = 0.017). Individuals with periodontitis are more likely to deliver lower-weight infants (OR = 0.983; 95% CI: 0.972 to 0.995; P = 0.005). We found no evidence of pleiotropy or heterogeneity in aforementioned two associations. We did not observe casual links with pre-pregnancy conditions and pregnancy complications. Conclusions This Mendelian Randomization study underscores the genetic influence of periodontitis on specific adverse pregnancy outcomes, particularly concerning labor duration and lower birth weight deliveries. Clinical relevance Our study emphasizes the critical importance of maintaining periodontal health during pregnancy and offers genetic evidence supporting these associations. Further investigation is required to delve deeper into the specific underlying mechanisms.

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Periodontal and caries status in unexplained female infertility: A case–control study

Cited by 10 publications

References 42 publications

Diagnostic Accuracy of Salivary aMMP-8 Test in Infertile Women and Blood Finding Analysis

Diagnostic Accuracy of Salivary aMMP-8 Test in Infertile Women and Blood Finding Analysis

Association between periodontitis and dental caries: a systematic review and meta-analysis

Maternal periodontitis may cause lower birth weight in children: genetic evidence from a comprehensive Mendelian randomization study on periodontitis and pregnancy

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