Periodontal Changes in Children and Adolescents With Diabetes

Lalla, Evanthia; Cheng, Bin; Lal, Shantanu; Tucker, Sid; Greenberg, Ellen; Goland, Robin; Lamster, Ira B.

doi:10.2337/diacare.29.02.06.dc05-1355

Cited by 181 publications

(211 citation statements)

References 25 publications

(19 reference statements)

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“…Recent epidemiological and experimental studies have revealed an association between periodontal disease and vascular disease [2][3][4]. Activation of endothelial cells and leukocyte-endothelial interaction play a central role in inflammation [5].…”

Section: Introductionmentioning

confidence: 99%

Treponema denticola induces interleukin-8 and macrophage chemoattractant protein 1 production in human umbilical vein epithelial cells

Okuda

Kimizuka

Miyamoto

et al. 2007

Microbes and Infection

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Treponema denticola, a major pathogen of periodontitis, has also been detected in the lesions of atherosclerosis. The aim of this study was to investigate induction of chemokine production in human umbilical vein endothelial cells (HUVECs) by T. denticola and determine whether those chemokines were degraded by a protease, dentilisin. T. denticola ATCC35405 or dentilisin-deficient mutant K1 were added to HUVECs and levels of interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) in the culture supernatants were determined by enzyme-linked immunosorbent assay. T. denticola ATCC35405 induced production of IL-8 in a time-dependent manner, with both production of IL-8 and expression of IL-8 mRNA showing higher levels than with exposure to dentilisin-deficient mutant K1. Although exposure to ATCC35405 induced expression of MCP-1 mRNA in the HUVECs, MCP-1 levels were remained similar to that in unstimulated cells. IL-8 and MCP-1 showed partial hydrolysis with exposure to T. denticola ATCC35405, but not with T. denticola K1. These results suggest that T. denticola can evade host defense mechanisms by modulating production of IL-8 and MCP-1, and that this play a role in the development of chronic infections such as periodontitis. The association of T. denticola infection to atherosclerosis was also discussed based on the present study.-3 -

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Section: Introductionmentioning

confidence: 99%

Treponema denticola induces interleukin-8 and macrophage chemoattractant protein 1 production in human umbilical vein epithelial cells

Okuda

Kimizuka

Miyamoto

et al. 2007

Microbes and Infection

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“…Most of the previous studies in children with systemic diseases especially diabetes demonstrating higher periodontal problems (15,16). The risk for periodontal destruction increased with diabetes (5).Thus, control of the systemic conditions is of importance for periodontal health.…”

Section: Discussionmentioning

confidence: 99%

Periodontal health status of children with type 1 diabetes mellitus

Gökmenoğlu¹,

Bavbek²,

Gürel³

et al. 2017

J Turgut Ozal Med Cent

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Aim: Type 1 diabetes mellitus (DM1) is the most common chronic disease in children and adolescents. The purpose of this study was to determine the relationship between Type 1 diabetes mellitus and periodontal health and also the effect of metabolic control level on both periodontal and dental health. Material and Methods: A Total of, 152 patients, of which 76 subjects with type 1 diabetes (DM1) and 76 healthy individuals were participated in this study. The subjects were also categorized with regard to gender and metabolic control levels. Periodontal health was assessed by recording plaque index (PI), gingival index (GI), pocket depth (PD) and bleeding on probing (BOP); while the dental status was determined by Decayed, Missing and Filled Teeth index (DMFT). Results: All periodontal scores were found to be significantly higher in DM1 group, whereas DMFT scores were similar in DM1 group and healthy controls. The glycemic control levels did not seem to have an impact on periodontal parameters (PI, GI, PD, BoP) and DMFT scores. Also, there were no statistically significant correlations between periodontal parameters and DMFT scores, and HbA1c values. Conclusion: Diabetes seems to be associated with poor periodontal health status regardless of the metabolic control level in adolescents, but not with increased caries risk.

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“…Depuis plusieurs décennies, le monde scientifique admet une relation entre la maladie parodontale et certaines maladies systémiques [8][9][10][11][12][13], comme l'endocardite [2], l'athérosclérose [14][15][16][17][18], le diabète [19,20], l'arthrite rhumatoïde [16,21] et les naissances prématurées [22]. Malgré une multitude d'études scientifiques, la physiopathologie précise que ces différentes relations entre les maladies parodontales et les maladies systémiques ne sont pas encore élucidées.…”

Section: Introductionunclassified

Impact de l’hygiène bucco-dentaire sur le sport. Revue de la littérature

Kipgen¹,

Kaux

Rompen

et al. 2015

Journal de Traumatologie du Sport

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RésuméLes dents font l'objet de multiples attentions et soins, mais il n'en va pas de même du parodonte, leur point d'ancrage et de soutien indispensable. Quoi de plus banal, en effet, qu'un saignement survenant lors du brossage quotidien ? Étant non douloureux, il ne déclenche bien souvent aucune inquiétude, ni aucune demande de consultation. Il s'agit pourtant d'un des signes cliniques évidents des parodontopathies qui affectent, à des degrés divers, pratiquement 90 % de la population en France dans toutes les tranches d'âge et causent la perte de 30 à 40 % des dents. Depuis plusieurs décennies, le monde scientifique admet une relation entre la maladie parodontale et certaines maladies systémiques, comme l'endocardite, l'athérosclérose, le diabète, l'arthrite rhumatoïde et les naissances prématurées. Et qu'en est-il des tendinopathies ? Leur survenue est souvent spontanée sans origine médicale spécifique et leur guérison s'avère longue et pénible. Cette revue a comme objectif de mettre en évidence les relations entre l'hygiène bucco-dentaire et ses répercussions sur les sportifs. © 2014 Elsevier Masson SAS. Tous droits réservés. AbstractTeeth are the object of multiple attentions and care but unfortunately, it is not the same case for the periodont, their point of anchoring and essential support. What could be more commonplace than a bleeding arising during the daily brushing? Being not painful, it activates very often no concern and no request of consultation. It is nevertheless about one of the most obvious clinical signs of the periodontal diseases which affect, to varying degrees, practically 90% of the population in France in all groups of ages and are responsible for the loss of 30 to 40% of the teeth. For several decades, the scientific world admits a relation between the periodontal disease and certain systemic diseases as endocarditis, atherosclerosis, diabetes, rheumatoid arthritis and preterm birth. And what about tendinopathies? Their appearance is often spontaneous without specific medical origin and their cure turns out long and painful. This review has for objective to highlight the relations between oral hygiene and sportsmen.

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Periodontal Changes in Children and Adolescents With Diabetes

Cited by 181 publications

References 25 publications

Treponema denticola induces interleukin-8 and macrophage chemoattractant protein 1 production in human umbilical vein epithelial cells

Treponema denticola induces interleukin-8 and macrophage chemoattractant protein 1 production in human umbilical vein epithelial cells

Periodontal health status of children with type 1 diabetes mellitus

Impact de l’hygiène bucco-dentaire sur le sport. Revue de la littérature

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