Periodontal disease: a genetic perspective

Taba, Mário; Souza, Sérgio Luı́s Scombatti de; Mariguela, Viviane Casagrande

doi:10.1590/s1806-83242012000700006

Cited by 45 publications

(41 citation statements)

References 42 publications

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“…Chronic periodontitis is the result of complex interaction between different genetic and non-genetic factors. The heritability, familial aggregation, twin studies, analyses of candidate loci and GWAS reveal that the genetic component has a weak or moderate effect on disease predisposition [10,11].…”

Section: Resultsmentioning

confidence: 99%

Single Nucleotide Polymorphisms in Two Inflammation-Related Genes and Chronic Periodontitis risk in Romanian Adults

Nica¹,

Nica²,

Gogianu³

et al. 2019

Rom Biotechnol Lett.

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Background:The existing literature showed conflicting data on the association between peridontosis and IL6 and TGFb1 polymorphisms.Aim: to investigate the correlation between susceptibility to chronic periodontitis and TGFb1 C-509T, IL6 G-174C polymorphisms and TTV infection in Romanian population.Materials and methods: Five hundred and fifteen subjects (260 healthy and 255 patients with chronic periodontitis) of Romanian origin were selected for this study. DNA was extracted from peripheral blood samples and the two polymorphisms and the presence of torque teno virus DNA were tested by PCR-based methods. StatsDirect was used for data analysis.Results: Our data showed that lifestyle choices (e.g. inadequate personal oral hygiene -O.R. =7.66, p<0.0001, taking irregular meals -O.R. =2.82, p<0.001 and smoking O.R.=1.5, p=0.01) increase the risk of periodontitis. We also identified differences in distribution of TGFb1 C-509T and IL-6 G-174C polymorphisms in patients and control groups. However, there was no association between the distribution of TGFb C-509T variants and the risk of periodontitis in male (p=0.85). There was an association between the presence of IL6 -174G allele and chronic periodontitis in the overall group of subjects (O.R.=1.6, p=0.01) and in men (O.R.=1.82, p=0.02), but not in women (p=0.2). The prevalence of TTV DNA and association with periodontitis was consistent with previous studies.Conclusions: Lifestyle choices, IL6 G-174C and TTV were associated with periodontitis in our lot. Further investigation conducted on a larger group with less confounding factors is required in order to validate these findings.

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Section: Resultsmentioning

confidence: 99%

Single Nucleotide Polymorphisms in Two Inflammation-Related Genes and Chronic Periodontitis risk in Romanian Adults

Nica¹,

Nica²,

Gogianu³

et al. 2019

Rom Biotechnol Lett.

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“…Several genetic polymorphisms have been studied for their relationship to periodontitis, including several interleukin (IL) genes, vitamin D receptors, and FcγRIIIb-NA1 gene. However, there is still no predictive as a diagnostic or prognostic marker to identify patients in the general population who are at periodontitis risk due to population heterogeneity and different disease criteria [12,13].…”

Section: Discussionmentioning

confidence: 99%

Periodontal Tissue Condition on Systemic Lupus Erythematosus Patients: A Clinical Study

Gofur

Nurdiana

Handono

et al. 2020

Pesqui. Bras. Odontopediatria Clín. Integr.

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Objective: To evaluate periodontal tissue condition on systemic lupus erythematosus (SLE) patients and its characteristics. Material and Methods: This descriptive and cross-sectional study involved 61 SLE patients. Clinical examination of the oral cavity was performed using periodontal index (PI), gingival index (GI), clinical attachment loss (CAL) and number of loose teeth. Also, we evaluated SLE duration, treatment duration, ethnics, marital status, educational background, family income, and occupation. Results: In the evaluation of periodontal tissue, 93.4% had bleeding on probing, 80.3% clinical attachment loss, and 16.3% loose teeth. A total of 54 patients (88.5%) with SLE had periodontitis. Seven subjects had no periodontitis, 11 mild periodontitis, 29 moderate periodontitis and 14 severe periodontitis. Mean Periodontal Index score, Gingival Index, Clinical Attachment Loss (mm), and the number of mobility teeth, Plaque Index and Calculus Index respectively were 2.66 ± 1.20, 1.95 ± 1.02, 0.75 ± 0.59 mm, 1,49 ± 1.77. There was a significant difference in periodontal index score, shown periodontitis between employment and unemployment subjects (p=0.004) and a moderate correlation between periodontitis and occupation. Conclusion: Periodontitis found as manifestations SLE patients, followed by bleeding on probing and loose teeth. Its characteristics is playing a role in periodontitis in SLE patients.

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“…Diabetes is also associated with periodontitis and it has been postulated that a more complete analysis of the periodontal microbiome is necessary to determine if this disease is associated with a dysbiotic periodontal community. Human genetic risk factors have been, and remain, the subject of numerous studies, which have been reviewed elsewhere . It will be interesting to see, in the future, if any of the putative periopathogenic single nucleotide polymorphisms in host‐response and other genes are associated with dysbiotic oral communities.…”

Section: What Causes Dysbiosis?mentioning

confidence: 99%

Microbial protection and virulence in periodontal tissue as a function of polymicrobial communities: symbiosis and dysbiosis

Roberts¹,

Darveau²

2015

Periodontology 2000

105

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This review discusses polymicrobial interactions with the host in both health and disease. As our ability improves to identify specific bacterial clonal types both with respect to abundance and location in the oral biofilm we will learn more concerning their contribution to both oral health and disease. Recent studies examining host-bacterial interactions have revealed that commensal bacteria not only protect the host simply by niche occupation, but that bacterial interactions with host tissue can promote the development of proper tissue structure and function. These data indicate that our host-associated polymicrobial communities, such as those found in the oral cavity, co-evolved with us and have become an integral part of who we are. Understanding the microbial community factors that underpin associations with host tissue that contribute to periodontal health may also reveal how dysbiotic periodontopathic oral communities disrupt normal periodontal tissue functions in disease. A disruption of the oral microbial community creates dysbiosis, either by overgrowth of specific or nonspecific microorganisms or changes in the local host response where the community can now support a disease state. Dysbiosis provides the link between systemic changes (e.g., diabetes), exogenous risk factors (e.g., smoking), and the dysbiotic community and can drive the periodontal tissue destruction. Many other risk factors associated with periodontal disease such as stress, aging, and genetics also likely affect the microbial community, and more research is needed utilizing sophisticated bacterial taxonomic techniques to better elucidate these effects on the microbiome and to develop strategies to target the dysbiotic mechanisms and improve periodontal health.

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Periodontal disease: a genetic perspective

Cited by 45 publications

References 42 publications

Single Nucleotide Polymorphisms in Two Inflammation-Related Genes and Chronic Periodontitis risk in Romanian Adults

Single Nucleotide Polymorphisms in Two Inflammation-Related Genes and Chronic Periodontitis risk in Romanian Adults

Periodontal Tissue Condition on Systemic Lupus Erythematosus Patients: A Clinical Study

Microbial protection and virulence in periodontal tissue as a function of polymicrobial communities: symbiosis and dysbiosis

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