Periodontal Disease and Breast Cancer: A Meta-Analysis of 1,73,162 Participants

Abstract

Objective: To investigate the correlation between periodontal disease and breast cancer.Materials and Methods: PubMed and China National Knowledge Infrastructure (CNKI) databases were searched up to February 8, 2018 for observational studies examining the association between periodontal disease and breast cancer. Study selection was conducted according to predesigned eligibility criteria, and two authors independently extracted data from included studies. Meta-analysis was performed using the Comprehensive Meta-Analysis v2 software and risk estimates were calculated as relative risks (RRs) with corresponding 95% confidence intervals (CIs).Results: A total of 11 study were included. Meta-analysis indicated that periodontal disease significantly increased the risk of breast cancer by 1.22-fold (RR = 1.22, 95% CI = 1.06–1.40). Amongst participants with periodontal patients and a history of periodontal therapy, the risk of developing breast cancer was not significant (RR = 1.23; 95% CI = 0.95–1.60). The association results between periodontal diseases and breast cancer were found to be robust, as evident in the leave-one-out sensitivity analysis.Conclusions: Periodontal disease may be a potential risk factor for the development of breast cancer among women, and thus effective periodontal therapy may present as a valuable preventive measure against breast cancer.

Breast cancer colonization by Fusobacterium nucleatum accelerates tumor growth and metastatic progression

“…Existing data provide support for positive association between periodontitis and risk of cancer 35,36 , particularly oral, lung, and pancreatic cancers 37 . A recent metaanalysis also predicted that periodontal disease increased the risk of breast cancer by 1.22-fold 38 .…”

Periodontal Disease and Age-Related Macular Degeneration: A Meta-Analysis of 112,240 Participants

“…Some studies only give the respective effect sizes and their 95% CIs for each severity of PD or AMD and did not give the total effect size and its 95% CI representing the correlation between PD and AMD. In order to observe whether PD and AMD are related in general, we used the fixed-effects model to combine the data of different degrees of disease in the same study, so as to obtain the total effect size and 95% CI of the study [ 28 ]. We converted the effect sizes and their 95% CIs into their logarithms and standard errors and then merged them.…”

Association between periodontitis and medication‐related osteonecrosis of the jaw: A systematic review and meta‐analysis

“…McGowan et al recently performed a systematic review on this matter identifying 39 different systemic diseases, 14 medical and 11 dental risk factors, thereby elucidating the complexity of this outcome . The close connection between PD and diseases which are commonly managed with ARs, independent of their consumption, and which tend to be either cancers —that particularly favour bone metastasis—, or osteoporosis, has recently been reported in observational studies, building a web of intrigue . On the other hand, the concept of at‐risk patients is hindered by the difficulty in establishing risk factors …”

“…47 The close connection between PD and diseases which are commonly managed with ARs, independent of their consumption, and which tend to be either cancers -that particularly favour bone metastasis-, or osteoporosis, has recently been reported in observational studies, building a web of intrigue. [48][49][50] On the other hand, the concept of at-risk patients is hindered by the difficulty in establishing risk factors. 47 Our study has several limitations.…”