Periodontal disease and C‐reactive protein‐associated cardiovascular risk

D’Aiuto, Francesco; Ready, Derren; Tonetti, Maurizio S.

doi:10.1111/j.1600-0765.2004.00731.x

Cited by 205 publications

(198 citation statements)

References 30 publications

(32 reference statements)

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“…If these clinical diagnostic tests could be applied to the screening of periodontal disease, the problems described above could be overcome (4)(5)(6)(7)(8)(9). Some reported studies have demonstrated a correlation between blood test parameters and periodontal status.…”

Section: Introductionmentioning

confidence: 99%

Screening of periodontitis with salivary enzyme tests

et al. 2006

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The purpose of this study was to determine the usefulness of salivary biochemical markers for the screening of periodontal disease and examine the agreement between the results of saliva enzyme tests and those of probing depth. The present study included a total of 187 subjects who underwent annual medical check-ups at the Comprehensive Health Care Center, Honjo, Saitama Prefecture, Japan. Periodontal pocket probing was performed with a WHO probe, and various enzymes and biochemical parameters in saliva were measured. For lactate dehydrogenase (LDH), the proportions of the five isoenzymes were calculated. To decide the cut-off point for each enzymatic activity, receiver operating characteristic curves (ROC curves) were constructed and the points of minimum difference between sensitivity and specificity were decided. Among the biochemical markers tested, salivary LDH level had the highest sensitivity and specificity (sensitivity 0.66, specificity 0.67), while salivary levels of aspartate aminotransferase (AST) and blood urea nitrogen (BUN) also had sensitivity and specificity above 0.60. Among the LDH isoenzymes, LDH4 and LDH5 dominated in whole saliva samples. Salivary LDH may be a feasible and useful parameter for the screening of periodontal disease, while salivary AST and BUN also appear to be potentially useful for this purpose. (J. Oral Sci. 48, [177][178][179][180][181][182][183] 2006)

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Section: Introductionmentioning

confidence: 99%

Screening of periodontitis with salivary enzyme tests

et al. 2006

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“…No se encuentra totalmente aclarado el papel de la proteína C-reactiva en la periodontitis, sin embargo algunos trabajos (11,16,23,24) intentan desvelar una posible relación entre la inflamación crónica, mediadores inflamatorios e imunológicos provenientes de la enfermedad periodontal con el aumento del riesgo de enfermedades cardiovasculares.…”

Section: Discussionunclassified

“…Basado en la publicación Asociación Americana del Corazón y del Centro para Controle de las Enfermedades en 2003, las concentraciones plasmáticas de PCR-US obtenidas por debajo de 0,1 mg/dL son consideradas de bajo riesgo de desarrollo de enfermedades cardiovasculares, mientras concentraciones variando entre 0,1-0,3 mg/dL son consideradas de mediano riesgo. Concentraciones mayores que 0,3 mg/dL se asocian con un mayor riesgo de desarrollo de enfermedades cardiovasculares siendo considerada la concentración de 0,3 mg/dL el punto de corte para definir individuos de alto riesgo cardiovascular (11). A la luz de los resultados obtenidos, la concentración promedio de PCR-US encontrada en el presente estudio para los pacientes con enfermedad periodontal fue de 0,36 mg/dL, mientras que en los individuos sin enfermedad periodontal esa concentra-ción presentó una media de 0,17 mg/dL.…”

Section: Tabla 4-estadística Descriptiva De La Concentración De Pcr-unclassified

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Proteína C-reactiva ultrasensible en pacientes con y sin periodontitis crónica severa generalizada

Bezerra¹,

Aquino²,

Lima

et al. 2009

Avances en Periodoncia

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Introducción: La proteína C-reactiva ultrasensible (PCR-US) constituye un mediador inflamatorio utilizado como predictor del riesgo cardiovascular que viene siendo investigado como factor indicativo de la relación entre enfermedades cardiovasculares y periodontales. Este trabajo tuvo como objetivo comparar los niveles séricos de proteína C-reactiva entre pacientes con y sin periodontitis crónica severa generalizada. Material y métodos: Se realizó un estudio seccional, utilizando una muestra de 60 pacientes, siendo 29 participantes con enfermedad periodontal (Grupo I) y 31 sin enfermedad (Grupo II). Como criterios de inclusión fueron seleccionados pacientes con diagnóstico de periodontitis crónica severa generalizada. La investigación constó de dos etapas, clínica y bioquímica. La clínica consistió en el examen periodontal y la bioquímica en la recogida de sangre para determinación de los niveles de PCR-US y un hemograma. Resultados: El grupo con enfermedad periodontal presentó una media de 0,36 mg/dl, mientras el sin enfermedad de 0,17 mg/dl (p=0,061). El riesgo cardiovascular para el grupo I fue clasificado como alto para 27,6% de los participantes y bajo para 72,4%. En el grupo II, 6,45% presentaban alto riesgo y 93,5% bajo riesgo, siendo esa relación estadísticamente significativa obtenida por el test de Fisher (p=0,042), presentando uno OR=5,33; IC95% (1,02-27,4). Las variables interventores investigadas no presentaron asociación estadísticamente significativa con los niveles de PCR-US. Conclusión: EL estudio indicó que pacientes portadores de periodontitis crónica severa generalizada no presentaron niveles séricos de PCR-US estadísticamente diferente de los pacientes sin enfermedad. La periodontitis actuó como factor asociado para la elevación de los niveles de la PCR-US, aunque con frágil asociación.

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“…Traditionally, the total number of WBC in peripheral blood has been used as a diagnostic measure to investigate whether a given individual suffers from an infection or inflammatory disease [11]. Studies have reported the relation between periodontal disease and inflammatory markers including CRP level [7][8][9][10][11][12][13][14][15][16][17] and WBC count [18,19]. Additionally, many clinical periodontal parameters were included, such as the number of missing teeth, clinical attachment level (CAL), periodontal probing depth (PD) and bleeding on probing (BOP), to determine the effect on systemic biomarkers, respectively.…”

Section: Introductionmentioning

confidence: 99%

Periodontal parameters and tooth loss were associated with Creactive protein and leukocyte counts in adult population aged 50 or older

et al. 2017

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·············································································································································································The association between periodontal disease and cardiovascular disease (CVD) has received considerable attention. This study investigated the correlation between tooth loss (the chief clinical parameter of periodontal disease) and systemic biomarkers of CVD, C-reactive protein (CRP) levels, and leukocyte (WBC) counts, in Koreans aged 50 years or older. A cross-sectional data of 5,322 participants was obtained from the 2008 to 2010 Dong-gu Study. Oral examination, survey questionnaire, physical examination, and biochemical assessments were performed. Oral examinations were completed in all dentate participants, and included the percentage of sites with ≥ 4 mm of probing depth (PD4%), clinical attachment level ≥ 4 mm (CAL4%), and bleeding on probing (BOP%). The number of missing teeth was categorized as 0-7, 8-15, 16-31, and edentulous. The serum CRP levels and WBC counts were assessed. Multivariate linear regression analysis was performed after adjusting for other potential confounders, to evaluate the association between the clinical parameters of periodontal disease, CRP levels and WBC counts. In the fully adjusted model, PD4%, BOP% and the number of missing teeth positively correlated with the CRP levels (p < 0.05), but CAL4% did not. The PD4%, CAL4%, and BOP% (p < 0.05) were concomitant with the WBC counts, but the number of missing teeth was not. The clinical parameters of periodontal disease and tooth loss directly correlated with CRP levels and WBC count in adults aged 50 years and above. This association indicates the potential significance of periodontal inflammatory burden for systemic inflammation.

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Periodontal disease and C‐reactive protein‐associated cardiovascular risk

Cited by 205 publications

References 30 publications

Screening of periodontitis with salivary enzyme tests

Screening of periodontitis with salivary enzyme tests

Proteína C-reactiva ultrasensible en pacientes con y sin periodontitis crónica severa generalizada

Periodontal parameters and tooth loss were associated with Creactive protein and leukocyte counts in adult population aged 50 or older

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